A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1089-1095

  Van de Merbel, Nico C ^a,b   Bronsema, Kees J ^a   van Hout, Mischa W J ^a   Nilsson, Ralf ^c   Sillén, Henrik ^c  

^a PRA Health Sciences   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

4 Hydroxycholesterol; APPI; Biomarker; CYP3A4 5; LC MS MS

Indexed keywords

4BETA HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; CRESOL; EDETIC ACID; HEXANE; OXYSTEROL; TOLUENE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ATMOSPHERIC PRESSURE; CONTROLLED STUDY; CRYOPRESERVATION; HUMAN; IN VITRO STUDY; LIPID HYDROLYSIS; NORMAL HUMAN; PLASMA; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; PURIFICATION; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTIOXIDANTS; BIOLOGICAL MARKERS; CALIBRATION; CHOLESTEROL; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP3A; EDETIC ACID; HUMANS; HYDROLYSIS; HYDROXYCHOLESTEROLS; IONS; MODELS, CHEMICAL; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 79956084944     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.03.017     Document Type: Article

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