-
1
-
-
33846607427
-
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach
-
Fuhr, U., Jetter, A. & Kirchheiner, J. Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach. Clin. Pharmacol. Ther. 81, 270-283 (2007).
-
(2007)
Clin. Pharmacol. Ther
, vol.81
, pp. 270-283
-
-
Fuhr, U.1
Jetter, A.2
Kirchheiner, J.3
-
2
-
-
0034007388
-
Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
-
Streetman, D.S., Bertino, J.S. Jr. & Nafziger, A.N. Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes. Pharmacogenetics 10, 187-216 (2000).
-
(2000)
Pharmacogenetics
, vol.10
, pp. 187-216
-
-
Streetman, D.S.1
Bertino Jr., J.S.2
Nafziger, A.N.3
-
3
-
-
0347361482
-
Urinary 6beta-hydroxycortisol: A validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals
-
Galteau, M.M. & Shamsa, F. Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals. Eur. J. Clin. Pharmacol. 59, 713-733 (2003).
-
(2003)
Eur. J. Clin. Pharmacol
, vol.59
, pp. 713-733
-
-
Galteau, M.M.1
Shamsa, F.2
-
4
-
-
0031868142
-
Urinary excretion of 6 beta-hydroxycortisol as an in vivo marker for CYP3A induction: Applications and recommendations
-
Kovacs, S.J., Martin, D.E., Everitt, D.E., Patterson, S.D. & Jorkasky, D.K. Urinary excretion of 6 beta-hydroxycortisol as an in vivo marker for CYP3A induction: applications and recommendations. Clin. Pharmacol. Ther. 63, 617-622 (1998).
-
(1998)
Clin. Pharmacol. Ther
, vol.63
, pp. 617-622
-
-
Kovacs, S.J.1
Martin, D.E.2
Everitt, D.E.3
Patterson, S.D.4
Jorkasky, D.K.5
-
5
-
-
0035914368
-
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: Evidence for involvement of cytochrome p450 3A4
-
Bodin, K. et al. Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4. J. Biol. Chem. 276, 38685-38689 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 38685-38689
-
-
Bodin, K.1
-
6
-
-
45849151673
-
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels
-
Josephson, F. et al. CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels. Eur. J. Clin. Pharmacol. 64, 775-781 (2008).
-
(2008)
Eur. J. Clin. Pharmacol
, vol.64
, pp. 775-781
-
-
Josephson, F.1
-
7
-
-
23244465392
-
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
-
Marschall, H.U. et al. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 129, 476-485 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 476-485
-
-
Marschall, H.U.1
-
8
-
-
33746255673
-
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin
-
Niemi, M. et al. Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin. Pharmacogenet. Genomics 16, 565-568 (2006).
-
(2006)
Pharmacogenet. Genomics
, vol.16
, pp. 565-568
-
-
Niemi, M.1
-
9
-
-
40049103597
-
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: Relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians
-
Diczfalusy, U. et al. 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Pharmacogenet. Genomics 18, 201-208 (2008).
-
(2008)
Pharmacogenet. Genomics
, vol.18
, pp. 201-208
-
-
Diczfalusy, U.1
-
10
-
-
17844387084
-
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil
-
Wang, Y.H., Jones, D.R. & Hall, S.D. Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab. Dispos. 33, 664-671 (2005).
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 664-671
-
-
Wang, Y.H.1
Jones, D.R.2
Hall, S.D.3
-
11
-
-
0038807786
-
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man
-
Mirghani, R.A., Ericsson, O., Tybring, G., Gustafsson, L.L. & Bertilsson, L. Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. Eur. J. Clin. Pharmacol. 59, 23-28 (2003).
-
(2003)
Eur. J. Clin. Pharmacol
, vol.59
, pp. 23-28
-
-
Mirghani, R.A.1
Ericsson, O.2
Tybring, G.3
Gustafsson, L.L.4
Bertilsson, L.5
-
12
-
-
0037200017
-
Metabolism of 4 beta-hydroxycholesterol in humans
-
Bodin, K. et al. Metabolism of 4 beta-hydroxycholesterol in humans. J. Biol. Chem. 277, 31534-31540 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 31534-31540
-
-
Bodin, K.1
-
13
-
-
0031696409
-
The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin
-
Gorski, J.C., Jones, D.R., Haehner-Daniels, B.D., Hamman, M.A., O'Mara, E.M. Jr. & Hall, S.D. The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin. Clin. Pharmacol. Ther. 64, 133-143 (1998).
-
(1998)
Clin. Pharmacol. Ther
, vol.64
, pp. 133-143
-
-
Gorski, J.C.1
Jones, D.R.2
Haehner-Daniels, B.D.3
Hamman, M.A.4
O'Mara Jr., E.M.5
Hall, S.D.6
-
14
-
-
28144454891
-
Effect of propiverine on cytochrome P450 enzymes: A cocktail interaction study in healthy volunteers
-
Tomalik-Scharte, D. et al. Effect of propiverine on cytochrome P450 enzymes: a cocktail interaction study in healthy volunteers. Drug Metab. Dispos. 33, 1859-1866 (2005).
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1859-1866
-
-
Tomalik-Scharte, D.1
-
15
-
-
0007204117
-
Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A
-
Kinirons, M.T. et al. Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A. Clin. Pharmacol. Ther. 66, 224-231 (1999).
-
(1999)
Clin. Pharmacol. Ther
, vol.66
, pp. 224-231
-
-
Kinirons, M.T.1
-
16
-
-
4744339424
-
In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam
-
Masica, A.L., Mayo, G. & Wilkinson, G.R. In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam. Clin. Pharmacol. Ther. 76, 341-349 (2004).
-
(2004)
Clin. Pharmacol. Ther
, vol.76
, pp. 341-349
-
-
Masica, A.L.1
Mayo, G.2
Wilkinson, G.R.3
-
17
-
-
17844393071
-
There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found
-
Benet, L.Z. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Mol. Interv. 5, 79-83 (2005).
-
(2005)
Mol. Interv
, vol.5
, pp. 79-83
-
-
Benet, L.Z.1
-
18
-
-
22544435261
-
CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition
-
Kharasch, E.D., Thummel, K.E. & Watkins, P.B. CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. Mol. Interv. 5, 151-153 (2005).
-
(2005)
Mol. Interv
, vol.5
, pp. 151-153
-
-
Kharasch, E.D.1
Thummel, K.E.2
Watkins, P.B.3
-
19
-
-
0022651439
-
Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration
-
Jochemsen, R., van Rijn, P.A., Hazelzet, T.G., van Boxtel, C.J. & Breimer, D.D. Comparative pharmacokinetics of midazolam and loprazolam in healthy subjects after oral administration. Biopharm. Drug Dispos. 7, 53-61 (1986).
-
(1986)
Biopharm. Drug Dispos
, vol.7
, pp. 53-61
-
-
Jochemsen, R.1
van Rijn, P.A.2
Hazelzet, T.G.3
van Boxtel, C.J.4
Breimer, D.D.5
-
20
-
-
58149129621
-
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin
-
Diczfalusy, U., Kanebratt, K.P., Bredberg, E., Andersson, T.B., Böttiger, Y. & Bertilsson, L. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. Br. J. Clin. Pharmacol. 67, 38-43 (2009).
-
(2009)
Br. J. Clin. Pharmacol
, vol.67
, pp. 38-43
-
-
Diczfalusy, U.1
Kanebratt, K.P.2
Bredberg, E.3
Andersson, T.B.4
Böttiger, Y.5
Bertilsson, L.6
-
21
-
-
0020261684
-
Physiologic and temporal variation in hepatic elimination of midazolam
-
Klotz, U. & Ziegler, G. Physiologic and temporal variation in hepatic elimination of midazolam. Clin. Pharmacol. Ther. 32, 107-112 (1982).
-
(1982)
Clin. Pharmacol. Ther
, vol.32
, pp. 107-112
-
-
Klotz, U.1
Ziegler, G.2
-
22
-
-
0021171925
-
Chronopharmacokinetic study with prolonged infusion of midazolam
-
Klotz, U. & Reimann, I.W. Chronopharmacokinetic study with prolonged infusion of midazolam. Clin. Pharmacokinet. 9, 469-474 (1984).
-
(1984)
Clin. Pharmacokinet
, vol.9
, pp. 469-474
-
-
Klotz, U.1
Reimann, I.W.2
-
23
-
-
56449089768
-
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance
-
Kharasch, E.D., Bedynek, P.S., Park, S., Whittington, D., Walker, A. & Hoffer, C. Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. Clin. Pharmacol. Ther. 84, 497-505 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 497-505
-
-
Kharasch, E.D.1
Bedynek, P.S.2
Park, S.3
Whittington, D.4
Walker, A.5
Hoffer, C.6
-
24
-
-
56449113167
-
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities
-
Kharasch, E.D., Bedynek, P.S., Walker, A., Whittington, D. & Hoffer, C. Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. Clin. Pharmacol. Ther. 84, 506-512 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 506-512
-
-
Kharasch, E.D.1
Bedynek, P.S.2
Walker, A.3
Whittington, D.4
Hoffer, C.5
-
25
-
-
0037855901
-
Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats
-
Walter, R., Ullmann, C., Thummler, D. & Siegmund, W. Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male rats. Drug Metab. Dispos. 31, 714-717 (2003).
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 714-717
-
-
Walter, R.1
Ullmann, C.2
Thummler, D.3
Siegmund, W.4
-
26
-
-
42149130238
-
Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy
-
Wide, K., Larsson, H., Bertilsson, L. & Diczfalusy, U. Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy. Br. J. Clin. Pharmacol. 65, 708-715 (2008).
-
(2008)
Br. J. Clin. Pharmacol
, vol.65
, pp. 708-715
-
-
Wide, K.1
Larsson, H.2
Bertilsson, L.3
Diczfalusy, U.4
-
27
-
-
33646568084
-
Enzymatic characteristics of CYP3A5 and CYP3A4: A comparison of in vitro kinetic and drug-drug interaction patterns
-
Emoto, C. & Iwasaki, K. Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns. Xenobiotica 36, 219-233 (2006).
-
(2006)
Xenobiotica
, vol.36
, pp. 219-233
-
-
Emoto, C.1
Iwasaki, K.2
-
28
-
-
53249129094
-
No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam
-
Tomalik-Scharte, D. et al. No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam. Eur. J. Clin. Pharmacol. 64, 1033-1035 (2008).
-
(2008)
Eur. J. Clin. Pharmacol
, vol.64
, pp. 1033-1035
-
-
Tomalik-Scharte, D.1
-
29
-
-
45549095805
-
Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients
-
Wyen, C. et al. Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. Clin. Pharmacol. Ther. 84, 75-82 (2008).
-
(2008)
Clin. Pharmacol. Ther
, vol.84
, pp. 75-82
-
-
Wyen, C.1
-
30
-
-
40049101739
-
Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity
-
Klaassen, T. et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur. J. Clin. Pharmacol. 64, 387-398 (2008).
-
(2008)
Eur. J. Clin. Pharmacol
, vol.64
, pp. 387-398
-
-
Klaassen, T.1
-
31
-
-
3042640736
-
High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
-
Lütjohann, D. et al. High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs. Steroids 69, 431-438 (2004).
-
(2004)
Steroids
, vol.69
, pp. 431-438
-
-
Lütjohann, D.1
-
32
-
-
0028971227
-
Identification and quantitation of cholest-5-ene-3 beta,4 beta-diol in rat liver and human plasma
-
Breuer, O. Identification and quantitation of cholest-5-ene-3 beta,4 beta-diol in rat liver and human plasma. J. Lipid Res. 36, 2275-2281 (1995).
-
(1995)
J. Lipid Res
, vol.36
, pp. 2275-2281
-
-
Breuer, O.1
-
33
-
-
0025859676
-
Lack of pharmacokinetic interaction as an equivalence problem
-
Steinijans, V.W., Hartmann, M., Huber, R. & Radtke, H.W. Lack of pharmacokinetic interaction as an equivalence problem. Int. J. Clin. Pharmacol. Ther. Toxicol. 29, 323-328 (1991).
-
(1991)
Int. J. Clin. Pharmacol. Ther. Toxicol
, vol.29
, pp. 323-328
-
-
Steinijans, V.W.1
Hartmann, M.2
Huber, R.3
Radtke, H.W.4
|