One-generation reproductive toxicity study of 2-methylbutane in Sprague-Dawley rats

Regulatory Toxicology and Pharmacology

Volumn 60, Issue 1, 2011, Pages 136-143

  Yu, Wook Joon ^a   Chung, Moon Koo ^a   Chung, Yong Hyun ^b   Kim, Hyoung Chin ^c   Kim, Sung Hwan ^d   Lee, In Chul ^d   Kim, Jong Choon ^d  

^a Korea Institute of Toxicology   (South Korea)

^b Occupational Safety and Health Research Institute   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

2 Methylbutane; Industrial chemical; Rats; Reproductive and developmental toxicity; Safety

Indexed keywords

ISOPENTANE;

ADRENAL GLAND; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONCEPTION; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GONAD FUNCTION; HISTOPATHOLOGY; KIDNEY MASS; LACTATION; MALE; MATING; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; WEANING; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; FEMALE; KIDNEY; KIDNEY DISEASES; KIDNEY TUBULES; LACTATION; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PENTANES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCTION; SOLVENTS;

ANIMALIA; RATTUS;

EID: 79956052829     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.03.003     Document Type: Article

References (26)

1. Documentation of the threshold limit values and biological exposure indices 1991, ACGIH, American Conference of Governmental Industrial Hygienists, Cincinnati, OH, ACGIH. 6th ed.
2. Andersen H., Larsen S., Spliid H., Christensen N.D. Multivariate statistical analysis of organ weights in toxicity studies. Toxicology 1999, 136:67-77.
3. Boorman G.A., Eustis S.L., Elwell M.R., Montgomery C.A., Mackenzie W.F. Pathology of the Fischer Rat. Reference and Atlas 1990, Academic Press, New York, San Diego, USA.
4. Chiba S., Oshida S. Metabolism and toxicity of n-pentane and isopentane. Nihon Hoigaku Zasshi 1991, 45:128-137.
5. Duffus J.F. World Health Organization, Geneva, 1979, agreed terms on health effects evaluation and risk and hazard assessment of environmental agents. Internal report of a working group, (EHE/EHC/79.19) in glossary for chemists of terms used in toxicology. Pure Appl. Chem. 1993, 65:2003-2122.
6. Dunnett C.W. New tables for multiple comparisons with a control. Biometrics 1964, 20:482-491.
7. Feron V.J., De Groot A.P., Spanjers M.T., Til H.P. An evaluation of the criterion "organ weight" under conditions of growth retardation. Food Cosmet. Toxicol. 1973, 11:85-94.
8. Fisher R.A. Statistical methods for research workers 1970, Oliver and Boyd, Edinburgh, UK. 14th ed.
9. Galvin J.B., Marashi F. 2-Methylbutane (isopentane). J. Toxicol. Environ. Health (A) 1999, 58:23-33.
10. Grandjean P. Individual susceptibility in occupational and environmental toxicology. Toxicol. Lett. 1995, 77:105-108.
11. Greaves P. Histopathology of Preclinical Studies: Interpretation and Relevance in Drug Evaluation 1990, Elsevier, New York, USA.
12. Gur E., Waner T. The variability of organ weight background data in rats. Lab. Ani. 1993, 27:65-72.
13. Halder C.A., Holdsworth C.E., Cockrell B.Y., Piccirillo V.J. Hydrocarbon nephropathy in male rats: identification of the nephrotoxic components of unleaded gasoline. Toxicol. Ind. Health 1985, 1:67-87.
14. Haschek W.M., Rousseaux C.G. Fundamentals of Toxicologic Pathology 1998, Academic Press, San Diego, USA.
15. Kim H.Y., Lee S.B., Chung Y.H., Lim C.H., Yu I.J., Park S.C., Shin J.Y., Kim S.H., Shin D.H., Kim J.C. Evaluation of subchronic inhalation toxicity of dimethyl disulfide in rats. Inhalation Toxicol. 2006, 18:395-403.
16. Kim H.Y., Lee S.B., Lim K.T., Kim M.K., Kim J.C. Subchronic inhalation toxicity study of 1,3-dichloro-2-propanol in rats. Ann. Occup. Hyg. 2007, 51:633-643.
17. Kioukia-Fougia N., Antoniou K., Bekris S., Liapi C., Christofidis I., Papadopoulou-Daifoti Z. The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels. Prog. Neuropsychopharmacol. Biol. Psychiat. 2002, 26:823-830.
18. Kruskal W.H., Wallis W.A. Use of ranks in one criterion variance analysis. J. Am. Stat. Assoc. 1952, 47:614-617.
19. Lieder P.H., Chang S.C., York R.G., Butenhoff J.L. Toxicological evaluation of potassium perfluorobutanesulfonate in a 90-day oral gavage study with Sprague-Dawley rats. Toxicology 2009, 255:45-52.
20. Odio M.R., Maickel R.P. Comparative biochemical responses of rats to different stressful stimuli. Physiol. Behav. 1985, 34:595-599.
21. OECD (Organization for Economic Cooperation and Development)., 1983. Guideline 415: One-generation reproduction toxicity study. Available from: <>. http://www.oecd.org.
22. Isopentane Toxicity Study Summary 1982, Phillips Petroleum Co., Hazelton Laboratories America, Inc., Bartlesville, OK.
23. Scheffe H. A method of judging all contrasts in the analysis of variance. Biometika 1953, 40:87-104.
24. Stuckardt J.L., Poppe S.M. Fresh visceral examination of rat and rabbit foetuses used in teratogenicity testing. Teratog. Carcinog. Mutagen. 1984, 4:181-188.
25. Tanaka E. Gender-related differences in pharmacokinetics and their clinical significance. J. Clin. Pharm. Ther. 1999, 24:339-346.
26. Ulrich-Lai Y.M., Figueiredo H.F., Ostrander M.M., Choi D.C., Engeland W.C., Herman J.P. Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E965-E973.