Glycoprotein IIb-IIIa content and platelet aggregation in healthy volunteers and patients with acute coronary syndrome

Platelets

Volumn 22, Issue 4, 2011, Pages 243-251

  Yakushkin, V V ^a   Zyuryaev, I T ^a   Khaspekova, S G ^a   Sirotkina, O V ^b   Ruda, M Ya ^a   Mazurov, A V ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^b PETERSBURG NUCLEAR PHYSICS INSTITUTE   (Russian Federation)

Author keywords

acute coronary syndrome; glycoprotein Ib; glycoprotein IIb IIIa; mean platelet volume; Platelet aggregation

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CLOPIDOGREL; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; LEUCINE; MONOCLONAL ANTIBODY;

ACUTE CORONARY SYNDROME; ALLELE; FIBRINOGEN BLOOD LEVEL; GENOTYPE; HUMAN; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; THROMBOCYTE RICH PLASMA; THROMBOCYTE VOLUME;

ACUTE CORONARY SYNDROME; BLOOD PLATELETS; FIBRINOGEN; HUMANS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POLYMORPHISM, GENETIC;

EID: 79956027695     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2010.547959     Document Type: Review

References (42)

1. Coller BS, Shatill SJ. The GP IIb/IIIa (integrinαIIbβ3) odyssey: A technology-driven saga of a receptor with twists, turns and even a bend. Blood 2008;112:3011-3025.
2. Plow EF, Pesho MM, Ma YQ. IntegrinαIIbβ3. In: Michelson AD, editor. Platelets, 2nd edn. Amsterdam: Academic Press, Elsevier Inc.; 2007. pp 165-178.
3. McEver RP, Baenziger NL, Majerus PW. Isolation and quantification of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody. J Clin Invest 1980;66:1311-1318. (Pubitemid 11205592)
4. Coller BS. A new monoclonal antibody reports an activationdependent change in the conformation and/or microenviroment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest 1985;76:101-108. (Pubitemid 15240423)
5. Wagner CL, Mascelli MA, Neblock DS, Weisman HF, Coller BS, Jordan RE. Analysis of GP IIb/IIIa receptor number by quantification of 7E3 binding to human platelets. Blood 1996;8:907-914. (Pubitemid 26333313)
6. Michelson AD. Flow cytometric analysis of platelet surface glycoproteins: Phenotypically distinct subpopulations of platelets in children with chronic myeloid leukemia. J Lab Clin Med 1987;110:346-354. (Pubitemid 18021159)
7. Gawaz M, Neumann FJ, Ott I, May A, Rudiger S, Schomig A. Changes in membrane glycoproteins of circulating platelets after coronary stent implantation. Heart 1996;76:166-172. (Pubitemid 26258745)
8. Quinn M, Deering A, Stewart M, Cox D, Foley B, Fitzgerald D. Quantifying GP IIb-IIIa receptor binding using 2 monoclonal antibodies. Discriminating abciximab and small molecular weight antagonists. Circulation 1999;99:2231-2238. (Pubitemid 29201127)
9. Mazurov AV, Pevzner DV, Khaspekova SG, Dudnik OA, Byzova TV, Vlasik TN, et al. Inhibition of thrombocyte aggregation by F(ab')2-fragments of monoclonal antibodies FraMon (CRC64) to glycoproteins IIb-IIIa. Ter Arkh 2001;73:66-73. (In Russian). (Pubitemid 33739757)
10. O'Halloran AM, Curtin R, O'Connar F, Dooley M, Fitzgerald A, O'Brian JK, et al. The impact of genetic variation in the region of the GP IIIa gene on PlA2 expression bias and GP IIb-IIIa receptor density in platelets. Br J Haematol 2006;132:494-502.
11. Sirotkina OV, Zabotina AM, Taraskina AE, Sivachenko EB, Zueva EE, Kadinskaya MI, et al. Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation. Bull Exp Biol Med 2007;143:422-425. (Pubitemid 47456571)
12. Sirotkina OV, Khaspekova SG, Zabotina AM, Shimanova YV, Mazurov AV. Effects of platelet glycoprotein IIb-IIIa number and glycoprotein IIIa Leu33Pro polymorphism on platelet aggregation and sensitivity to glycoprotein IIb-IIIa antagonists. Platelets 2007;18:506-514. (Pubitemid 350034854)
13. Khaspekova SG, Sirotkina OV, Shimanova IuV, Mazurov AV. Variations in glycoprotein IIb-IIIa (alphaIIb/beta3-integrin) content in healthy donors. Influence on platelet aggregation activity and efficacy of aspirin action. Biomed Khim 2008; 54:361-371. (In Russian).
14. Thcheng JE, Ellis SG, George BS, Kereiakes DJ, Kleiman NS, Talley JD, et al. Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antiplatelet antibody Fab 7E3 in high-risk coronary angioplasty. Circulation 1994;90:1757-1764. (Pubitemid 24320922)
15. Mazurov AV, Pevzner DV, Antonova OA, Byzova TV, Khaspekova SG, Semenov AV, et al. Safety, inhibition of platelet aggregation and pharmacokinetics of F(ab')2 fragments of the anti-glycoprotein IIb-IIIa monoclonal antibody FRaMon in high-risk coronary angioplasty. Platelets 2002;13:465-477. (Pubitemid 35373661)
16. Gabbasov ZA, Popov EG, Gavrilov IYu, Pozin EYa. Platelet aggregation: The use of optical density fluctuations to study microaggregate formation in platelet suspension. Thromb Res 1989;54:215-223. (Pubitemid 19140511)
17. Gabbasov Z, Parfyonova Y, Popov E, Gavrilov I, Anuchin V, Dubov P, Djakonova Y. Association of platelet function in hypertensive patients with left ventricular hyperthrophy, transient myocardial ischemia, and coronary artery disease. Platelets 1998;9:191-195. (Pubitemid 28312678)
18. Eto K, Takeshita S, Ochiai M, Ozaki Y, Sato T, Isshiki T. Platelet aggregation in acute coronary syndromes: Use of a new aggregometer with laser light scattering to assess platelet aggregability. Cardiovasc Res 1998;40:223-229. (Pubitemid 28435447)
19. Afshar-Kharghan V, Vijayan KV, Bray PF. Platelet polymorphism. In: Michelson AD, editor. Platelets, 2nd edn. Amsterdam: Academic Press, Elsevier Inc.; 2007. pp 281-307.
20. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996;334:1090-1094. (Pubitemid 26120186)
21. Reiner AP, Siscovick DS, Rosendaal FR. Platelet glycoprotein gene polymorphisms and risk of thrombosis: Facts and fancies. Rev Clin Exp Hematol 2001;5:262-287. (Pubitemid 34947706)
22. Burr D, Doss H, Cooke GE, Goldschmidt-Clermont PJ. A meta-analysis of studies on the association of the platelet PlA polymorphisms of glycoprotein IIIa and risk of coronary heart disease. Stat Med 2003;22:1741-1760. (Pubitemid 36575612)
23. Di Castelnuovo A, de Gaetano G, Benedetta Donati M, Iacoviello L. Platelet glycoprotein IIb/IIIa polymorphism and coronary artery disease: Implication for clinical practice. Am J Pharmacogenomics 2005;5:93-99. (Pubitemid 40593435)
24. Vijayan KV, Bray PF. Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enchanced outside-in signaling through the Pro33 variant of integrin beta 3. Exp Biol Med 2006;231:505-513.
25. Vijayan KV, Goldschmidt-Clermont PJ, Roos C, Bray PF. The Pl(A2) polymorphism of integrin beta(3) enchances outside-in signaling and adhesive functions. J Clin Invest 2000;105:793-802. (Pubitemid 30164118)
26. Goodall AH, Curzen N, Panesar M, Hurd C, Knight CJ, Ouwehand WH, Fox KM. Increased binding of fibrinogen to glycoprotein IIIa-Proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease. Eur Heart J 1999;20:742-747. (Pubitemid 29209907)
27. Michelson AD, Furman MI, Goldschmidt-Clermont P, Mascelli MA, Hendrix C, Coleman L, et al. Platelet GP IIIa PlA polymorphisms display different sensitivities to agonists. Circulation 2000;101:1013-1018. (Pubitemid 30131704)
28. Huang T, Sahud MA. Association of C807T, Pl(A), and -5 C/T Kozak genotypes with density of glycoprotein receptors on platelet surface. Thromb Res 2003;112:147-150. (Pubitemid 38201602)
29. Feng D, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Lipinska I, et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: The Framingham Offspring Study. Artherioscler Thromb Vasc Biol 1999;19:1142-1147. (Pubitemid 29177367)
30. Bennett JS, Catella-Lawson F, Rut AR, Vilaire G, Qi W, Kapoor SC, Murphy S, FitzGerald GA. Effect of the PlA2 alloantigen on the function of 3-integrins in platelets. Blood 2001;97:3093-3099.
31. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Stherland PA, et al. Platelet glycoprotein IIIa Pla polymorphism, fibrinogen, and platelet aggregability. The Framingham heart study. Circulation 2001;104:140-144. (Pubitemid 32655828)
32. Meade TW, Vickers MV, Thompson SG, Stirling Y, Haines AP, Miller GJ. Epidimiological characteristics of platelet aggregability. Br Med J 1985;90:428-432.
33. Zurn CS, Geisler T, Gawaz M. ADP-receptor blockage: A case for personalized pharmacotherapy. Thromb Haemost 2010;103:496-506.
34. Mazurov AV, Vinogradov DV, Vlasik TN, Repin VS, Booth WJ, Berndt MC. Characterization of an antiglycoprotein Ib monoclonal antibody that specifically inhibits platelet-thrombin interaction. Thromb Res 1991;62:673-684.
35. Leytin V, Shapiro H, Radney J. Flow cytometric analysis of the platelet surface area and surface density of glycoprotein IIb-IIIa of unactivated human platelets of various sizes. Biochem Biophys Res Commun 1996;226:94-100. (Pubitemid 26332169)
36. Tschoepe D, Kaufmann L, Schauseil S, Kehrel B, Ostermann H, Gries FA. Evidence for abnormal platelet glycoprotein expression in diabetes mellitus. Eur J Clin Invest 1990;20:166-170. (Pubitemid 20126655)
37. Giles H, Smith RE, Martin JF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest 1994;24:69-72. (Pubitemid 24204957)
38. Frojmovic M, Wong T. Dynamic measurements of the platelet membrane glycoproteinIIb-IIIa receptor for fibrinogen by flow cytometry. II. Platelet size-dependent subpopulations. Biophys J 1991;59:828-837.
39. Guthikonda S, Alviar CL, Vaduganathan M, Arikan M, Tellez A, DeLao T, et al. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable artery disease. J. Am Coll Cardiol 2008;52:743-743.
40. Thompson CB, Jakubowsky JA, Quinn PG, Deykin D, Valeri CR. Platelet size as a determinant of platelet function. J Lab Clin Med 1983;101:205-213. (Pubitemid 13152003)
41. Wong T, Pedvis L, Frojmovic M. Platelet size affects both micro- and macro-aggregation: Contribution of platelet number, volume fraction and cell surface. Thromb Haemost 1989;62:733-741. (Pubitemid 19267428)
42. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkie B, et al. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost 2010;8:148-156.