Sequestration of Camptothecin, an Anticancer Alkaloid, by Chrysomelid Beetles

Journal of Chemical Ecology

Volumn 37, Issue 5, 2011, Pages 533-536

  Ramesha, B T ^a   Zuehlke, S ^b   Vijaya, R C ^a   Priti, V ^a,c   Ravikanth, G ^a,c   Ganeshaiah, K N ^a,c   Spiteller, M ^b   Shaanker, R Uma ^a,c  

^a UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

^b TU DORTMUND UNIVERSITY   (Germany)

^c ASHOKA TRUST FOR RESEARCH IN ECOLOGY AND THE ENVIRONMENT   (India)

Author keywords

Alkaloid; Anti cancer; Camptothecin; Chrysomelid beetles; Sequestration; Topoisomerase I

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN;

ALKALOID; BEETLE; BIOCHEMICAL COMPOSITION; CANCER; CHEMICAL ECOLOGY; CONCENTRATION (COMPOSITION); DICOTYLEDON; ENZYME ACTIVITY; FEEDING; GAS CHROMATOGRAPHY; INHIBITOR; LEAF; LIQUID CHROMATOGRAPHY; MONOTERPENE; SEQUESTRATION (CHEMISTRY); TOLERANCE;

ANGIOSPERM; ANIMAL; ARTICLE; BEETLE; METABOLISM; PARASITOLOGY; PLANT LEAF;

ANGIOSPERMS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BEETLES; CAMPTOTHECIN; PLANT LEAVES;

ASTERIDS; CHRYSOMELIDAE; COLEOPTERA; EUKARYOTA; HEXAPODA; ICACINACEAE; NOTHAPODYTES;

EID: 79955997517     PISSN: 00980331     EISSN: 15731561     Source Type: Journal    
DOI: 10.1007/s10886-011-9946-z     Document Type: Article

References (12)

1. Aregullin, M., and Rodriguez, E. 2003. Sesquiterpene lactone sequestration by the tortoise beetle Physonota arizonae (Cassidinae). J. Mex. Chem. Soc. 47: 143-145.
2. Cunha, K. S., Reguly, M. L., Graf, U., and Rodrigues de Andrade, H. H. 2002. Comparison of camptothecin derivatives presently in clinical trials: genotoxic potency and mitotic recombination. Mutagenesis. 17: 141-147.
3. Despres, L., David, J. P., and Gallet, C. 2007. The evolutionary ecology of insect resistance to plant chemicals. Trends Ecol. Evol. 22: 298-307.
4. Hartmann, T., Theuring, C., Witte, L., and Pasteels, J. M. 2001. Sequestration, metabolism and partial synthesis of tertiary pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. Insect Biochem. Mol. Biol. 31: 1041-1056.
5. Hsiang, Y. H., Hertzberg, R., Hecht, S., and Liu, L. F. 1985. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase-I. J. Biol. Chem. 260: 14873-14878.
6. Larsson, S. 2007. The new chemosystematics: phylogeny and phytochemistry. Phytochemistry 68: 2903-2907.
7. Li, S. 2002. Utilizing Camptotheca products for termite control. US Patent Application No. 20020018762.
8. Pommier, Y. 2006. Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer 6: 789-802.
9. Ramesha, B. T., Amna, T., Ravikanth, G., Rajesh Gunaga, P., Vasudeva, R., Ganeshaiah, K. N., Uma Shaanker, R., Khajuria, R. K., Puri, S. C., and Qazi, G. N. 2008. Prospecting for camptothecins from Nothapodytes nimmoniana in the Western Ghats, south India: identification of high yielding sources of camptothecin and new families of camptothecins. J. Chromatogr. Sci. 46: 362-368.
10. Schroeder, F. C., del Campo, M. L., Grant, J. B., Weibel, D. B., Smedley, S. R., Bolton, K. L., Meinwald, J., Eisner, T. 2006. Pinoresinol: A lignol of plant origin serving for defense in a caterpillar. Proc. Natl. Acad. Sci. U. S. A. 103: 15497-15501.
11. Sirikantaramas, S., Yamazaki, M., and Saito, K. 2008. Mutations in topoisomerase-I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. Proc. Natl. Acad. Sci. U. S. A. 105: 6782-6786.
12. Willinger, G., and Dobler, S. 2001. Selective sequestration of iridoid glycosides from their host plants in Longitarsus flea beetles. Biochem. Syst. Ecol. 29: 335-346.