Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis

Cardiology

Volumn 118, Issue 2, 2011, Pages 140-146

  Mohty, D ^c   Pibarot, P ^b   Cote N ^a   Cartier, A ^b   Audet, A ^a   Despres J P ^b   Mathieu, P ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

Adiponectin; Aortic stenosis; Calcific aortic valve disease; Inflammation

Indexed keywords

ADIPONECTIN; CD45 ANTIGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VON WILLEBRAND FACTOR;

ABNORMALLY LOW SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AGED; AORTA STENOSIS; AORTA VALVE; AORTA VALVE REPLACEMENT; ARTICLE; BLOOD VESSEL; CD3+ T LYMPHOCYTE; CELL DENSITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ECHOCARDIOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HEMODYNAMICS; HUMAN; HUMAN TISSUE; HYPOADIPONECTINEMIA; IMMUNOHISTOLOGY; INFLAMMATION; LEUKOCYTE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEOVASCULARIZATION (PATHOLOGY); PREOPERATIVE PERIOD; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; AGED; AGED, 80 AND OVER; AORTIC VALVE STENOSIS; DISEASE PROGRESSION; ECHOCARDIOGRAPHY; FEMALE; HEART VALVE PROSTHESIS; HEMODYNAMICS; HUMANS; INFLAMMATION; LINEAR MODELS; MALE; MIDDLE AGED;

EID: 79955969057     PISSN: 00086312     EISSN: 14219751     Source Type: Journal    
DOI: 10.1159/000327588     Document Type: Article

References (23)

1. Cote C, Pibarot P, Despres JP, Mohty D, Cartier A, Arsenault BJ, Couture C, Mathieu P: Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis. Heart 2008;94:1175-1180.
2. Mathieu P, Lemieux I, Despres JP: Obesity, inflammation, and cardiovascular risk. Clin Pharmacol Ther 2010;87:407-416.
3. Mathieu P, Pibarot P, Despres JP: Metabolic syndrome: the danger signal in atherosclerosis. Vasc Health Risk Manag 2006;2:285-302. (Pubitemid 44275464)
4. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83. (Pubitemid 29299050)
5. Briand M, Lemieux I, Dumesnil JG, Mathieu P, Cartier A, Despres JP, Arsenault M, Couet J, Pibarot P: Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis. J Am Coll Cardiol 2006;47:2229-2236. (Pubitemid 43795081)
6. Katz R, Wong ND, Kronmal R, Takasu J, Shavelle DM, Probstfield JL, Bertoni AG, Budoff MJ, O'Brien KD: Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valve calcification in the Multi-Ethnic Study of Atherosclerosis. Circulation 2006;113:2113-2119.
7. Bosse Y, Miqdad A, Fournier D, Pepin A, Pibarot P, Mathieu P: Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves. Circ Cardiovasc Genet 2009;2:489-498.
8. Derbali H, Bosse Y, Cote N, Pibarot P, Audet A, Pepin A, Arsenault B, Couture C, Despres JP, Mathieu P: Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2. Am J Pathol 2010;176:2638-2645.
9. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD: Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994;90:844-853.
10. Charest A, Pepin A, Shetty R, Cote C, Voisine P, Dagenais F, Pibarot P, Mathieu P: Distribution of SPARC during neovascularisation of degenerative aortic stenosis. Heart 2006;92:1844-1849. (Pubitemid 44851338)
11. O'Brien KD: Calcific aortic valve disease: a disease process comes of age? EB 2007. Introduction. J Investig Med 2007;55:277.
12. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, Bonow RO, Spelsberg T: Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003;107:2181-2184. (Pubitemid 36547209)
13. Ouchi N, Walsh K: Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007;380:24-30. (Pubitemid 46498041)
14. Mathieu P, Poirier P, Pibarot P, Lemieux I, Despres JP: Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease. Hypertension 2009;53:577-584.
15. Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, Hokanson JE, Ehrlich J, Eckel RH, Rewers M: Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 2005;111:747-753. (Pubitemid 40250635)
16. Mathieu P, Pibarot P, Larose E, Poirier P, Marette A, Despres JP: Visceral obesity and the heart. Int J Biochem Cell Biol 2008;40:821-836.
17. Despres JP, Arsenault BJ, Cote M, Cartier A, Lemieux I: Abdominal obesity: the cholesterol of the 21st century? Can J Cardiol 2008;24(suppl D):7D-12D.
18. Ford ES: Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care 2005;28:2745-2749.
19. Trujillo ME, Scherer PE: Adiponectin - journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005;257:167-175. (Pubitemid 40193966)
20. Drolet MC, Roussel E, Deshaies Y, Couet J, Arsenault M: A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice. J Am Coll Cardiol 2006;47:850-855. (Pubitemid 43243111)
21. Briand M, Pibarot P, Despres JP, Voisine P, Dumesnil JG, Dagenais F, Mathieu P: Metabolic syndrome is associated with faster degeneration of bioprosthetic valves. Circulation 2006;114:I512-I517. (Pubitemid 44297200)
22. Mathieu P, Despres JP, Pibarot P: The 'valvulo-metabolic' risk in calcific aortic valve disease. Can J Cardiol 2007;23(suppl B):32B-39B.
23. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-1599. (Pubitemid 30353893)