Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells

Journal of Biomedical Optics

Volumn 16, Issue 1, 2011, Pages

  Vandepitte, Joachim ^a   Roelants, Mieke ^a   Cleynenbreugel, Ben Van ^b   Hettinger, Klaudia ^c   Lerut, Evelyne ^b   Van Poppel, Hendrik ^b   De Witte, Peter A M ^a  

^a Faculteit Farmaceutische Wetenschappen   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Sanochemia Pharmazeutika AG   (Austria)

Author keywords

biodistribution; bladder cancer; photodynamic therapy; PVP hypericin; tumor spheroids

Indexed keywords

BIODISTRIBUTIONS; BLADDER CANCER; BLADDER CANCERS; CELL SURVIVAL; CLINICAL SITUATIONS; FLUENCE RATES; FLUORESCENCE IMAGE; HIGH-SENSITIVITY; HYPERICINS; IN-VITRO; IN-VIVO EXPERIMENTS; LIGHT FLUENCE RATE; MULTICELLULAR SPHEROID; PHOTODYNAMIC EFFECT; POLYVINYL PYRROLIDONE; PVP-HYPERICIN; THERAPEUTIC EFFECTS; TRANSITIONAL CELL CARCINOMA; TUMOR SPHEROIDS; UROTHELIAL CELLS; UROTHELIUM;

CELL CULTURE; DISEASES; OXYGENATION; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS;

CELLS;

DRUG DERIVATIVE; HYPERICIN; PERYLENE; PHOTOSENSITIZING AGENT; POVIDONE;

ARTICLE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HUMAN; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; TISSUE DISTRIBUTION; TRANSITIONAL CELL CARCINOMA; UROTHELIUM;

CARCINOMA, TRANSITIONAL CELL; CELL LINE; CELL SURVIVAL; HUMANS; PERYLENE; PHOTOSENSITIZING AGENTS; POVIDONE; SPHEROIDS, CELLULAR; TISSUE DISTRIBUTION; UROTHELIUM;

EID: 79955961356     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3533316     Document Type: Article

References (24)

1. J. Ferlay, D. M. Parkin, and E. Steliarova-Foucher, Estimates of cancer incidence and mortality in Europe in 2008., Eur. J. Cancer 46 (4), 765-781 (2010). 10.1016/j.ejca.2009.12.014
2. K. Hendricksen and J. A. Witjes, Current strategies for first and second line intravesical therapy for nonmuscle invasive bladder cancer., Curr. Opin. Urol. 17 (5), 352-357 (2007). 10.1097/MOU.0b013e3281c55f2b (Pubitemid 47351133)
3. P. Jichlinski and H. J. Leisinger, Photodynamic therapy in superficial bladder cancer: past, present and future., Urol. Res. 29 (6), 396-405 (2001). 10.1007/s002400100215 (Pubitemid 34042186)
4. D. C. Shackley, C. Whitehurst, J. V. Moore, N. J. George, C. D. Betts, and N. W. Clarke, Light penetration in bladder tissue: implications for the intravesical photodynamic therapy of bladder tumours., BJU Int. 86 (6), 638-643 (2000). 10.1046/j.1464-410x.2000.00872.x
5. D. E. Dolmans, D. Fukumura, and R. K. Jain, Photodynamic therapy for cancer., Nat. Rev. Cancer 3 (5), 380-387 (2003). 10.1038/nrc1071 (Pubitemid 37328858)
6. M. Triesscheijn, P. Baas, J. H. Schellens, and F. A. Stewart, Photodynamic therapy in oncology., Oncologist 11 (9), 1034-1044 (2006). 10.1634/theoncologist.11-9-1034 (Pubitemid 44564813)
7. R. Waidelich, W. Beyer, R. Knuchel, H. Stepp, R. Baumgartner, J. Schroder, A. Hofstetter, and M. Kriegmair, Whole bladder photodynamic therapy with 5-aminolevulinic acid using a white light source., Urology 61 (2), 332-337 (2003). 10.1016/S0090-4295(02)02164-7 (Pubitemid 36206527)
8. M. Kriegmair, R. Baumgartner, W. Lumper, R. Waidelich, and A. Hofstetter, Early clinical experience with 5-aminolevulinic acid for the photodynamic therapy of superficial bladder cancer., Br. J. Urol. 77 (5), 667-671 (1996). 10.1046/j.1464-410X.1996.09717.x (Pubitemid 27402272)
9. R. J. Skyrme, A. J. French, S. N. Datta, R. Allman, M. D. Mason, and P. N. Matthews, A phase-1 study of sequential mitomycin C and 5-aminolaevulinic acid-mediated photodynamic therapy in recurrent superficial bladder carcinoma., BJU Int. 95 (9), 1206-1210 (2005). 10.1111/j.1464-410X.2005.05506.x (Pubitemid 40799431)
10. S. Collaud, A. Juzeniene, J. Moan, and N. Lange, On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation., Curr. Med. Chem. Anticancer Agents 4 (3), 301-316 (2004). 10.2174/1568011043352984 (Pubitemid 38647588)
11. M. A. D'Hallewin, P. A. De Witte, E. Waelkens, W. Merlevede, and L. Baert, Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin., J. Urol. 164 (2), 349-351 (2000). 10.1016/S0022-5347(05)67357-0 (Pubitemid 30481922)
12. M. A. D'Hallewin, A. R. Kamuhabwa, T. Roskams, P. A. De Witte, and L. Baert, Hypericin-based fluorescence diagnosis of bladder carcinoma., BJU Int. 89 (7), 760-763 (2002). 10.1046/j.1464-410X.2002.02690.x (Pubitemid 34429548)
13. H. G. Sim, W. K. Lau, M. Olivo, P. H. Tan, and C. W. Cheng, Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma. BJU Int. 95 (9), 1215-1218 (2005). 10.1111/j.1464-410X.2005.05508.x (Pubitemid 40799433)
14. A. Huygens, A. R. Kamuhabwa, T. Roskams, B. Van Cleynenbreugel, H. Van Poppel, and P. A. de Witte, Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells., J. Urol. 174 (1), 69-72 (2005). 10.1097/01.ju.0000162037. 49102.56 (Pubitemid 40825674)
15. A. Huygens, I. Crnolatac, J. Develter, B. Van Cleynenbreugel, T. Van der Kwast, and P. A. de Witte, Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin., J. Urol. 179 (5), 2014-2019 (2008). 10.1016/j.juro.2007.12.038
16. M. Van De Putte, T. Roskams, G. Bormans, A. Verbruggen, and P. A. De Witte, The impact of aggregation on the biodistribution of hypericin., Int. J. Oncol. 28 (3), 655-660 (2006).
17. A. Kubin, H. G. Loew, U. Burner, G. Jessner, H. Kolbabek, and F. Wierrani, How to make hypericin water-soluble., Pharmazie 63 (4), 263-269 (2008). 10.1111/j.1751-1097.2008.00384.x (Pubitemid 351543023)
18. A. Kubin, P. Meissner, F. Wierrani, U. Burner, A. Bodenteich, A. Pytel, and N. Schmeller, Fluorescence diagnosis of bladder cancer with new water soluble hypericin bound to polyvinylpyrrolidone: PVP-hypericin., Photochem. Photobiol. 84 (6), 1560-1563 (2008). 10.1111/j.1751-1097.2008.00384.x
19. S. J. Madsen, C. H. Sun, B. J. Tromberg, V. Cristini, N. De Magalhaes, and H. Hirschberg, Multicell tumor spheroids in photodynamic therapy., Lasers Surg. Med. 38 (5), 555-564 (2006). 10.1002/lsm.20350
20. J. Southgate, K. A. Hutton, D. F. Thomas, and L. K. Trejdosiewicz, Normal human urothelial cells in vitro: proliferation and induction of stratification., Lab. Invest. 71 (4), 583-594 (1994). (Pubitemid 24338167)
21. J. M. Yuhas, A. P. Li, A. O. Martinez, and A. J. Ladman, A simplified method for production and growth of multicellular tumor spheroids., Cancer Res. 37 (10), 3639-3643 (1977). (Pubitemid 8198426)
22. A. R. Kamuhabwa, A. Huygens, and P. A. De Witte, Photodynamic therapy of transitional cell carcinoma multicellular tumor spheroids with hypericin., Int. J. Oncol. 23 (5), 1445-1450 (2003). 10.1002/ijc.11396 (Pubitemid 37266468)
23. A. R. Kamuhabwa, A. Huygens, T. Roskams, and P. A. De Witte, Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin., Int. J. Oncol. 28 (3), 775-780 (2006).
24. A. Huygens, A. R. Kamuhabwa, A. Van Laethem, T. Roskams, B. Van Cleynenbreugel, H. Van Poppel, P. Agostinis, and P. A. De Witte, Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation., Int. J. Oncol. 26 (6), 1691-1697 (2005).