Experimental subacute spinal cord compression: Correlation of serial S100B and NSE serum measurements, histopathological changes, and outcome

Neurological Research

Volumn 33, Issue 4, 2011, Pages 421-426

  Marquardt, Gerhard ^a   Setzer, Matthias ^a   Theisen, Alf ^a   Tews, Dominique Suzanne ^a   Seifert, Volker ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Histopathology; NSE; Outcome; S100B; Spinal cord compression

Indexed keywords

BIOCHEMICAL MARKER; NEURON SPECIFIC ENOLASE; PROTEIN S100B;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; HISTOPATHOLOGY; MORPHOMETRICS; NONHUMAN; PARESIS; PROGNOSIS; PROTEIN BLOOD LEVEL; RABBIT; REACTION TIME; SPINAL CORD COMPRESSION; SPINAL CORD FUNCTION; THORACIC SPINAL CORD;

ACUTE DISEASE; ANIMALS; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; NERVE DEGENERATION; NERVE GROWTH FACTORS; NEURONS; PARESIS; PHOSPHOPYRUVATE HYDRATASE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RABBITS; S100 PROTEINS; SEVERITY OF ILLNESS INDEX; SPINAL CORD COMPRESSION;

EID: 79955956378     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/1743132810Y.0000000005     Document Type: Article

References (15)

1. Kim RY, Spencer SA, Meredith RF, Weppelmann B, Lee JY, Smith JW, et al. Extradural spinal cord compression: analysis of factors determining functional prognosis-prospective study. Radiology 1990;176:279-82.
2. Bach F, Larsen BH, Rohde K, Børgesen SE, Gjerris F, Bøge-Rasmussen T, et al. Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir (Wien) 1990;107:37-43.
3. Ghogawala Z, Mansfield FL, Borges LF. Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine 2001;26:818-24.
4. Helweg-Larsen S, Sorensen PS, Kreiner S. Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 2000;46:1163-9.
5. Lovey G, Koch K, Gademann G. Metastatic epidural spinal compression: prognostic factors and results of radiotherapy. Strahlenther Onkol 2001;177:676-9.
6. Onimus M, Papin P, Gangloff S. Results of surgical treatment of spinal thoracic and lumbar metastases. Eur Spine J 1996;5:407-11.
7. Marquardt G, Setzer M, Seifert V. Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien) 2004;146:449-52.
8. Marquardt G, Setzer M, Seifert V. Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine 2004;29:59-62.
9. Marquardt G, Setzer M, Theisen A, Dettmann E, Seifert V. A novel dynamic model for experimental spinal cord compression. J Neurosurg Spine 2005;2:466-71.
10. Anderson DK, Hall ED. Pathophysiology of spinal cord trauma. Ann Emerg Med 1993;22:987-92.
11. Anthes DL, Theriault E, Tator CH. Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury. Brain Res 1995;702:1-16.
12. Beattie MS, Farooqui AA, Bresnahan JC. Review of current evidence for apoptosis after spinal cord injury. J Neurotrauma 2000;17:915-25.
13. Emery E, Aldana P, Bunge MB, Puckett W, Srinivasan A, Keane RW, et al. Apoptosis after traumatic human spinal cord injury. J Neurosurg 1998;89:911-20.
14. McAdoo DJ, Hughes MG, Xu GY, Robak G, de Castro R Jr. Microdialysis studies of the role of chemical agents in secondary damage upon spinal cord injury. J Neurotrauma 1997;14:507-15.
15. Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 1991;75:15-26.