Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: A systematic review;Comparación de la efectividad, la seguridad y la aceptación de los abortos médicos practicados en el domicilio con aquellos realizados en la clínica: Una revisión sistemática

Bulletin of the World Health Organization

Volumn 89, Issue 5, 2011, Pages 360-370

  Ngo, Thoai D ^a   Park, Min Hae ^b   Shakura, Haleema ^a   Free, Caroline ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b MARIE STOPES INTERNATIONAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; MISOPROSTOL;

ABORTION; COHORT ANALYSIS; COMPARATIVE STUDY; MEDICAL GEOGRAPHY; SAFETY;

ABDOMINAL CRAMP; ARTICLE; BLEEDING; CHILL; DRUG FEVER; FEVER; HOME; HUMAN; MEDICAL ABORTION; MUSCLE CRAMP; NAUSEA; PAIN; PATIENT ATTITUDE; PATIENT SAFETY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; VOMITING;

ABORTIFACIENT AGENTS, STEROIDAL; ABORTION, INDUCED; ADOLESCENT; ADULT; AMBULATORY CARE FACILITIES; COMPARATIVE EFFECTIVENESS RESEARCH; DRUG THERAPY, COMBINATION; FEMALE; HOME CARE SERVICES; HUMANS; MIDDLE AGED; MIFEPRISTONE; MISOPROSTOL; PATIENT SATISFACTION; PREGNANCY; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 79955955605     PISSN: 00429686     EISSN: 15640604     Source Type: Journal    
DOI: 10.2471/BLT.10.084046     Document Type: Article

References (36)

1. Creinin MD. Medical abortion regimens: historical context and overview. Am J Obstet Gynecol 2000;183(Suppl):S3-S9. doi:10.1067/mob.2000.107948 PMID:10944364
2. Berer M. Medical abortion: issues of choice and acceptability. Reprod Health Matters 2005;13:25-34. doi:10.1016/S0968-8080(05)26204-3 PMID:16291483
3. Berer M. Medical abortion: a fact sheet. Reprod Health Matters 2005;13:20-24. doi:10.1016/S0968-8080(05)26212-2 PMID:16366018
4. Clark WH, Gold M, Grossman D, Winikoff B. Can mifepristone medical abortion be simplified? A review of the evidence and questions for future research. Contraception 2007;75:245-250. doi:10.1016/j. contraception.2006.11.011 PMID:17362700
5. Ho PC. Women's perceptions on medical abortion. Contraception 2006;74:11-15. doi:10.1016/j.contraception.2006.02.012 PMID:16781253
6. Jones RK, Henshaw SK. Mifepristone for early medical abortion: experiences in France, Great Britain and Sweden. Perspect Sex Reprod Health 2002;34:154-161. doi:10.2307/3097714 PMID:12137129
7. Shannon C, Wiebe E, Jacot F, Guilbert E, Dunn S, Sheldon WR et al. Regimens of misoprostol with mifepristone for early medical abortion: a randomized trial. BJOG 2006;113:621-628. doi:10.1111/j.1471-0528.2006.00948.xPMID:16709204
8. Akin A, Dabash R, Dilbaz B, Aktün H, Dursun P, Kiran S et al. Increasing women's choices in medical abortion: a study of misoprostol 400 microg swallowed immediately or held sublingually following 200 mg mifepristone. Eur J Contracept Reprod Health Care 2009;14:169-175. doi:10.1080/13625180902916020 PMID:19565414
9. Akin A, Blum J, Ozalp S, Onderog̈lu L, Kirca U, Bilgili N et al. Results and lessons learned from a small medical abortion clinical study in Turkey. Contraception 2004;70:401-406. doi:10.1016/j.contraception.2004.05.005 PMID:15504380
10. Creinin MD, Fox MC, Teal S, Chen A, Schaff EA, Meyn LA; MOD Study Trial Group. A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion. Obstet Gynecol 2004;103:851-859. doi:10.1097/01.AOG.0000124271.23499.84 PMID:15121556
11. Creinin MD, Schreiber CA, Bednarek P, Lintu H, Wagner M-S, Meyn LA; Medical Abortion at the Same Time (MAST) Study Trial Group. Mifepristone and misoprostol administered simultaneously versus 24 hours apart for abortion: a randomized controlled trial. Obstet Gynecol 2007;109:885-894. doi:10.1097/01.AOG.0000258298.35143.d2 PMID:17400850
12. Pymar HC, Creinin MD, Schwartz JL. Mifepristone followed on the same dayby vaginal misoprostol for early abortion. Contraception 2001;64:87-92. doi:10.1016/S0010-7824(01)00228-1 PMID:11704084
13. Clark WH, Hassoun D, Gemzell-Danielsson K, Fiala C, Winikoff B. Home use of two doses of misoprostol after mifepristone for medical abortion: a pilot study in Sweden and France. Eur J Contracept Reprod Health Care 2005;10:184-191. doi:10.1080/13625180500284581 PMID:16318966
14. Faucher P, Baunot N, Madelenat P. Efficacité et acceptabilité de l'interruption volontaire de grossesse par méthode médicamenteuse pratiquée sans hospitalisation dans le cadre d'un réseau ville-hôpital: étude prospective sur 433 patientes. [The efficacy and acceptability of mifepristone medical abortion with home administration misoprostol provided by private providers linked with the hospital: A prospective study of 433 patients] Gynecol Obstet Fertil 2005;33:220-227. [French.] doi:10.1016/j.gyobfe.2005.02.021 PMID:15894206
15. Fiala C, Winikoff B, Helström L, Hellborg M, Gemzell-Danielsson K. Acceptability of home-use of misoprostol in medical abortion. Contraception 2004;70:387-392. doi:10.1016/j.contraception.2004.06.005 PMID:15504378
16. Hamoda H, Ashok PW, Flett GMM, Templeton A. Home self-administrationof misoprostol for medical abortion up to 56 days' gestation. J Fam PlannReprod Health Care 2005;31:189-192. doi:10.1783/1471189054483915 PMID:16105279
17. Jørgensen H, Qvigstad E, Jerve F, Melseth E, Eskild A, Nielsen CS. Induced abortion at home. Tidsskr Nor Laegeforen 2007;127:2367-2370. PMID:17895940
18. Blum J, Hajri S, Chélli H, Mansour FB, Gueddana N, Winikoff B. The medical abortion experiences of married and unmarried women in Tunis, Tunisia. Contraception 2004;69:63-69. doi:10.1016/j.contraception.2003.08.019 PMID:14720623
19. Chuni N, Chandrashekhar TS. Early pregnancy termination with a simplified mifepristone: Medical abortion outpatient regimen. Kathmandu Univ Med J 2009;7:209-212. PMID:20071864
20. Guengant JP, Bangou J, Elul B, Ellertson C. Mifepristone-misoprostol medical abortion: home administration of misoprostol in Guadeloupe. Contraception 1999;60:167-172. doi:10.1016/S0010-7824(99)00074-8 PMID:10640161
21. Ho PC. Women's perceptions on medical abortion. Contraception 2006;74:11-15. doi:10.1016/j.contraception.2006.02.012 PMID:16781253
22. Kulier R, Gulmezoglu AM, Hofmeyr GJ, Cheng L, Campana A. Medical methods for first trimester abortion. Cochrane Database Syst Rev 2004. CD002855. doi:10.1002/14651858.CD002855.pub3
23. Kahn JG, Becker BJ, MacIsaa L, Amory JK, Neuhaus J, Olkin I et al. The efficacy of medical abortion: a meta-analysis. Contraception 2000;61:29-40. doi:10.1016/S0010-7824(99)00115-8 PMID:10745067
24. Bracken H, Gliozheni O, Kati K, Manoku N, Moisiu R, Shannon C et al.; Medical Abortion Research Group. Mifepristone medical abortion in Albania: results from a pilot clinical research study. Eur J Contracept Reprod Health Care 2006;11:38-46. doi:10.1080/13625180500361058 PMID:16546815
25. Bracken H; Family Planning Association of India (FPAI)/Gynuity Health Projects Research Group for Simplifying Medical Abortion in India. Home administration of misoprostol for early medical abortion in India. Int J Gynaecol Obstet 2010;108:228-232. doi:10.1016/j.ijgo.2009.09.027 PMID:19945104
26. Dagousset I, Fourrier E, Aubény E, Taurelle R. Enquête d'acceptabilité du misoprostol à domicile pour interruption volontaire de grossesse par méthode médicamenteuse. [Use of misoprostol for medical abortion: a trial of the acceptability for home use.] Gynecol Obstet Fertil 2004;32:28-33. [French.] doi:10.1016/j.gyobfe.2003.11.005 PMID:14736597
27. Elul B, Hajri S, Ngoc NN, Ellertson C, Slama CB, Pearlman E et al. Can women in less-developed countries use a simplified medical abortion regimen? Lancet 2001;357:1402-1405. doi:10.1016/S0140-6736(00)04563-3 PMID:11356438
28. Hajri S, Blum J, Gueddana N, Saadi H, Maazoun L, Chélli H et al. Expanding medical abortion in Tunisia: women's experiences from a multi-site expansion study. Contraception 2004;70:487-491. doi:10.1016/j. contraception.2004.06.012 PMID:15541411
29. Karki C, Pokharel H, Kushwaha A, Manandhar D, Bracken H, Winikoff B. Acceptability and feasibility of medical abortion in Nepal. Int J Gynaecol Obstet 2009;106:39-42. doi:10.1016/j.ijgo.2009.02.007 PMID:19345944
30. Ngoc NTN, Nhan VQ, Blum J, Mai TTP, Durocher JM, Winikoff B. Is home-based administration of prostaglandin safe and feasible for medical abortion? Results from a multisite study in Vietnam. BJOG 2004;111:814-819. doi:10.1111/j.1471-0528.2004.00209.x PMID:15270929
31. Provansal M, Mimari R, Gregoire B, Agostini A, Thirion X, Gamerre M. Interruption volontaire de grossesse médicamenteuse à domicile et à l'hôpital: étude d'efficacité et d'acceptabilité. [Medical abortion at home and at hospital: a trial of efficacy and acceptability] Gynecol Obstet Fertil 2009;37:850-856. doi:10.1016/j.gyobfe.2009.07.016 PMID:19766038
32. Reeves BC, Deeks JJ, Higgins JPT, Wells GA. Chapter 13: Including nonrandomized studies. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.0.2 (updated September 2009). The Cochrane Collaboration 2009. Available from: www.cochrane-handbook.org [accessed 16 February 2011].
33. Bracken H, Clark W, Lichtenberg ES, Schweikert SM, Tanenhaus J, Barajas A et al. Alternatives to routine ultrasound for eligibility assessment prior to early termination of pregnancy with mifepristone-misoprostol. BJOG 2011;118:17-23. doi:10.1111/j.1471-0528.2010.02753.x PMID:21091926
34. von Hertzen H, Baird D; Bellagio Study and Conference Center. Frequently asked questions about medical abortion. Contraception 2006;74:3-10. doi:10.1016/j.contraception.2006.03.029 PMID:16781252
35. Sitruk-Ware R. Mifepristone and misoprostol sequential regimen side effects, complications and safety. Contraception 2006;74:48-55. doi:10.1016/j.contraception.2006.03.016 PMID:16781261
36. Unsafe abortion: global and regional estimates of unsafe abortion and associated mortality in 2000. Geneva: World Health Organization, 2004.