A randomized comparison of misoprostol 6 to 8 hours versus 24 hours after mifepristone for abortion

Obstetrics and Gynecology

Volumn 103, Issue 5 I, 2004, Pages 851-859

  Creinin, Mitchell D ^a   Fox, Michelle C ^b   Teal, Stephanie ^b   Chen, Angela ^b   Schaff, Eric A ^b   Meyn, Leslie A ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MIFEPRISTONE; MISOPROSTOL; ABORTIVE AGENT;

ABORTION; ADULT; ARTICLE; ASPIRATION; BLEEDING; CHILL; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; FETUS; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MUSCLE CRAMP; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SPOTTING; STATISTICAL SIGNIFICANCE; TRANSVAGINAL ECHOGRAPHY; TREATMENT FAILURE; VOMITING; COMPARATIVE STUDY; DRUG ADMINISTRATION; FOLLOW UP; INDUCED ABORTION; PROSPECTIVE STUDY; TIME;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTIFACIENT AGENTS, STEROIDAL; ABORTION, INDUCED; ADULT; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HUMANS; MIFEPRISTONE; MISOPROSTOL; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 2942746316     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000124271.23499.84     Document Type: Article

References (29)

1. Peyron R, Aubeny E, Targosz V, Silvestre L, Renault M, Elkik F, et al. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med 1993;328:1509-13.
2. Schaff EA, Fielding SL, Westhoff C, Ellertson C, Eisinger SH, Stadalius LS, et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial (published erratum appears in JAMA 2000;284:2597). JAMA 2000;284:1948-53.
3. Schaff EA, Fielding SL, Westhoff C, Ellertson C, Eisinger SH, Stadalius LS, et al. Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: a randomized trial (published erratum appears in JAMA 2000;284:2597). JAMA 2000;284:1948-53.
4. Schaff EA, Fielding SL, Westhoff C. Randomized trial of oral versus vaginal misoprostol at one day after mifepristone for early medical abortion. Contraception 2001;64: 81-5.
5. Pymar HC, Creinin MD, Schwartz JL. Mifepristone followed on the same day by vaginal misoprostol for early abortion. Contraception 2001;64:87-92.
6. Fox MC, Creinin MD, Harwood B. Mifepristone followed on the same day by vaginal misoprostol for early abortion between 50 and 63 days gestation. Contraception 2002;66: 225-9.
7. Rossavik IK, Torjusen GO, Gibbons WE. Conceptual age and ultrasound measurements of gestational sac and crown-rump length in in vitro fertilization pregnancies. Fertil Steril 1988;49:1012-7.
8. Goldstein SR, Wolfson R. Endovaginal ultrasonographic measurement of early embryonic size as a means of assessing gestational age. J Ultrasound Med 1994;13:27-31.
9. Pocock SJ, editor. Clinical trials: a practical approach. Chichester (NY): John Wiley & Sons, 1983.
10. Katz J, Melzack R. Measurement of pain [review]. Surg Clin North Am 1999;79:231-52.
11. Flaherty SA. Pain measurement tools for clinical practice and research [review]. AANA J 1996;64:133-40.
12. Creinin MD. Randomized comparison of efficacy, acceptability and cost of medical versus surgical abortion. Contraception 2000;62:117-24.
13. el-Refaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med 1995;332: 983-7.
14. Ashok P, Penney G, Flett G, Templeton A. An effective regimen for early medical abortion: a report of 2000 consecutive cases. Hum Reprod 1998;13:2962-5.
15. Schaff EA, Eisinger SH, Stadalius LS, Franks P, Gore BZ, Poppema S. Low-dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999;59:1-6.
16. Schaff EA, Fielding SL, Eisinger SH, Stadalius LS, Fuller L. Low-dose mifepristone followed by vaginal misoprostol at 48 hours for abortion up to 63 days. Contraception 2000; 61:41-6.
17. Bartley J, Brown A, Elton R, Baird DT. Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or misoprostol for induction of abortion up to 63 days gestation. Hum Reprod 2001;16:2098-102.
18. Jain JK, Dutton C, Harwood B, Meckstroth KR, Mishell DR Jr. A prospective randomized, double-blinded, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy. Hum Reprod 2002;17: 1477-82.
19. Kang S, Chen JJ. An approximate unconditional test of non-inferiority between two proportions. Statist Med 2000;19:2089-100.
20. O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979;5:549-56.
21. Fisher LD, van Belle G. Biostatistics: a methodology for the health sciences. 1st ed. New York (NY): John Wiley & Sons; 1993.
22. Creinin MD, Vittinghoff E. Methotrexate and misoprostol vs misoprostol alone for early abortion: a randomized controlled trial. JAMA 1994;272:1190-5.
23. Elger W, Fahnrich M, Beier S, Qing SS, Chwalisz K. Endometrial and myometrial effects of progesterone antagonists in pregnant guinea pigs. Am J Obstet Gynecol 1987;157:1065-74.
24. Kelly RW, Bukman A. Antiprogestagenic inhibition of uterine prostaglandin inactivation: a permissive mechanism for uterine stimulation. J Steroid Biochem Mol Biol 1990;37:97-101.
25. Elger W, Beier S, Chwalisz K, Fahnrich M, Hasan SH, Henderson D, et al. Studies on the mechanisms of action of progesterone antagonists. J Steroid Biochem 1986;25: 835-45.
26. Swahn ML, Bygdeman M. The effect of the antiprogestin RU 486 on uterine contractility and sensitivity to prostaglandin and oxytocin. Br J Obstet Gynaecol 1988;95: 126-34.
27. Johannisson E, Oberholzer M, Swahn ML, Bygdeman M. Vascular changes in the human endometrium following the administration of the progesterone antagonist RU 486. Contraception 1989;39:103-17.
28. Creinin MD, Schwartz JL, Pymar HC, Fink W. Efficacy of mifepristone followed on the same day by misoprostol for early termination of pregnancy: report of a randomised trial. Br J Obstet Gynaecol 2001;108:469-73.
29. Spitz IM, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med 1998;338:1241-7.