Cardiospermum halicacabum inhibits cyclophosphamide induced immunosupression and oxidative stress in mice and also regulates iNOS and COX-2 gene expression in LPS stimulated macrophages

Asian Pacific Journal of Cancer Prevention

Volumn 11, Issue 5, 2010, Pages 1245-1252

  Pratheeshkumar, P ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Cardiospermum halicacabum L; COX 2; CTX; Immunomodulation; iNos; Oxidative stress

Indexed keywords

EID: 79955952470     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Ahmed I, Ahmad M, Ahmad A. (1993). Chemical investigation of the genus cardiospermum of the family sapindaceae. Science Int, Lahore, 5, 67-9.
2. Amudha G, Josephine A, Mythili Y, et al. (2007). Therapeutic efficacy of dl-_-lipoic acid on cyclosporine A induced renal alterations. Eur J Pharmacol, 571, 209-14.
3. Anderstam B, Vaca C, Ringdahl MH. (1992). Lipid peroxide level in a murine adenocarcinoma exposed to hyperthermia: the role of glutathione depletion. Radiat Res, 132, 296-300.
4. Asai K, Kato H, Kimura S, et al. (1996). Induction of gene expression for nitric oxide synthase by immuno-modulating drugs in the RAW264.7 murine macrophage cell line. Cancer Immunol Immunother, 42, 275-9.
5. Asha VV, Pushpangadan P. (1999). Antipyretic activity of Cardiospermum halicacabum. Indian J Exp Biol, 37, 411-4.
6. Bancroft JD, Cook HF. (1984). Manual of histologic technique. Churchill Livingstone, London, 171-4.
7. Bergmeyer HU, Bernt E. (1980). Colorimetric method for aspartate aniline aminotransferases. In Varley H, Gowenlock AH, Bell M, editors. Practical clinical biochemistry, 5th ed. London: William Heinemann Medical Books Ltd.
8. Borish L, Rosenwasser LJ. (1996). Update on cytokines. J Allergy Clin Immunol, 97, 719-34.
9. Borish LC, Steinke JW. (2003). Cytokines and chemokines. J Allergy Clin Immunol, 111, S460-75.
10. Comporti M. (1987). Glutathione depleting agentsand lipid peroxidation. Chem Phys Lipids, 45, 143-69.
11. Davis L, Kuttan G. (1998). Suppressive effect of cyclophosphamideinduced toxicity by Withania somnifera extract in mice. Immunopharmacol Immunotoxicol, 62, 695-703.
12. Dickinson DA, Forman HJ. (2002). Cellular glutathion and thiols metabolism. Biochem Pharmacol, 64, 1019-26.
13. Dinarello CA. (2000). Proinflammatory cytokines. Chest, 118, 503-8.
14. Ehrhacat RO, Ludviksson BR, Gray B, et al. (1997). Induction and prevention of chronic inflammation in IL-2 deficent mice. J Immunol, 158, 566-71.
15. Ferrara L, Schettino O, Montesano D. (1996). Triterpenoids from cardiospermum halicacabum L. Phytother Res, 10, S192-4.
16. Gasson JC. (1991). Molecular physiology of granulocytemacrophage colonystimulating factor. Blood, 77, 1131-45.
17. Gonsette RE, Demnty L. (1986). Immunosuppression with cyclophosphamide (Endoxan) in multiple sclerosis. In: Hommes OR, Mertin J, Tourtellotte WW, editors. Immunotherapies in Multiple Sclerosis. Sutton: Stuart Phillips Publications; p. 139-50.
18. Gopalakrishnan C, Dhananjayan R, Kameswaran L. (1976). Studies on the pharmacological actions of Cardiospermum halicacabum. Indian J Physiol Pharmacol, 20, 203-8.
19. Hersh EM, Freiriech EJ. (1968). In: Busch, H. (Ed.), Methods in Cancer Research Vol. 4, p. 355A, Academic Press, New York.
20. King JC. (1965). The phosphorous. In practical clinical enzymology. London: Van Nostrand, 191.
21. Lee SH, Soyoola E, Chanmugam P, et al. (1992). Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem, 267, 25934-8.
22. Lowenstein CJ, Snyder SH. (1992). Nitric oxide, novel biologic messenger. Cell, 70, 705.
23. Meister A, Andersen ME. (1983). Glutathione. Ann Rev Biochem, 52, 711-60.
24. Morandi P, Ruffini PA, Benvenuto GM, et al. (2005). Cardiac toxicity of high-dose chemotherapy. Bone Marrow Transplantation, 35, 323-34.
25. Moron MA, Depierre JW, Mannervick B. (1979). Levels of glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta, 582, 67-8.
26. Murray RL. (1984). Nonprotein compounds, in clinical chemistry: theory, analysis and Co-relation, Kaplan LA. and Pesce AJ., Eds. Mosby C.V. Toranto, 1230-68.
27. Nathan C, Sporn M. (1991). Cytokines in context. J Cell Biol, 113, 981-6.
28. Neuwinger HD. (2000). African traditional medicine: a dictionary of plant use and applications. Medpharm GmbH Scientific Publishers, Stuttgart, Germany, 1-300.
29. Newman DJ, Cragg GM. (2007). Natural products as sources of new drugs over the last 25 years. J Nat Prod, 70, 461-77.
30. Okhawa H, Ohoshi N, Yogi K. (1979). Anal biochem, 95-351.
31. Papaldo P, Lopez M, Marolla P, et al. (2005). Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with Epirubicin and cyclophosphamide. J Clin Oncol, 23, 6908-18.
32. Pass GJ, Carrie D, Boylan M, et al. (2005). Role of hepatic cytochrome P450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome P450 reductase null mouse. Cancer Res, 65, 4211-7.
33. Payvandi F, Wu L, Haley M, et al. (2004). Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cellular Immunol, 230, 81-8.
34. Petrangolini G, Pratesi G, De Cesare M, et al. (2003). Antiangiogenic effects of the novel camptothecin ST1481 (gimatecan) in human tumor xenografts. Mol Cancer Res, 1, 863-70.
35. Praveen K, Kuttan R, Kuttan G. (1996). Radioprotective effect of Rasayanas. Indian J Exp Biol, 34, 848-50.
36. Sadique J, Chandra T, Thenmozhi V, et al. (1987). Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation. J Ethnopharmacol, 19, 201-12.
37. Schwartz J, Domchek SM, Hwang WT, et al. (2005). Evaluation of anemia, neutropenia and skin toxicities in standard or dose-dense doxorubicin/ cyclophosphamide (AC)-paclitaxel or docetaxel adjuvant chemotherapy in breast cancer. Ann Oncol, 16, 247-52.
38. Sengupta S, Sellers LA, Cindrova T, et al. (2003). Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res, 63, 8351-9.
39. Sengupta S, Sellers LA, Cindrova T, et al. (2003). Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res, 63, 8351-9.
40. Sheeba MS, Asha VV. (2006). Effect of cardiospermum halicacabum on ethanolinduced gastric ulcers in rats. J Ethnopharmacol, 106, 105-10.
41. Sheeja K, Kuttan G. (2006). Ameliorating effects of andrographis paniculata extract against cyclophosphamide-induced toxicity in mice. Asian Pac J Cancer Prev, 7, 609-14.
42. Sikka SC. (2004). Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J Androl, 25, 5-18.
43. Sredni B, Albeck M, Kazimirsky G, Shalet F. (1992). Immunomodulator AS 101 administered orally as a chemoprotective and radioprotective agent. Int J Immunopharmacol, 14, 613-9.
44. Srinivas K, Choudary KA, Rao SS, et al. (1998). Phytochemical examination of Cardiospermum halicacabum Linn. Indian J Nat Prod, 14, 24-7.
45. Theze J, Alzari PM, Bertoglio J. (1996). Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol Today, 18, 487-92.
46. Toro G, Ackermann PG. (1975). Practical clinical chemistry, Little Brown & Co., Boston, 154.
47. Tsujii M, Kawano S, Tsuji S, et al. (1998). Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell, 29, 705-16.
48. Venkateshbabu KC. (2006). Cardiospermum halicacabum suppresses the production of TNF-α and NO by human peripheral blood mononuclear cells. African J Biomed Res, 9, 95-9.
49. Wagner H. (1984). In: Hiroshi Hikino, N.R., Farnsworth (Eds.), Economic and medicinal plant research. Academic Press, London, 1, 113-53.
50. Wang W, Lönnroth C, Svanberg E, et al. (2001). Cytokine and cyclooxygenase-2 protein in brain areas of tumor-bearing mice with prostanoid-related anorexia. Cancer Res, 61, 4707-15.
51. Xie QW, Cho H, Calaycay J, et al. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science, 256, 225-8.