Peripheral artery calcifications evaluated by histology correlate to those detected by CT: Relationships with fetuin-A and FGF-23

Journal of Nephrology

Volumn 24, Issue 3, 2011, Pages 313-321

  Coen, Giorgio ^a   de Paolis, Paolo ^b   Ballanti, Paola ^c   Pierantozzi, Andrea ^a   Pisanò, Stefania ^a   Sardella, Daniela ^a   Mantella, Daniela ^b   Pellegrino, Luigi ^d   Silvestrini, Giuliana ^c   Iappelli, Massimo ^b   di Giulio, Salvatore ^b  

^a Piazza San Bartolomeo All'Isola 21   (Italy)

^b SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

Calcification score; Fetuin A; FGF 23; Hemodialysis; Medial arterial calcification

Indexed keywords

FETUIN A; FIBROBLAST GROWTH FACTOR 23;

ADULT; AGATSTON SCORE; AGE; ARTERY CALCIFICATION; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CORRELATION ANALYSIS; EPIGASTRIC ARTERY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY TRANSPLANTATION; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; SCORING SYSTEM;

ADULT; BIOLOGICAL MARKERS; BLOOD PROTEINS; CALCINOSIS; CROSS-SECTIONAL STUDIES; FEMALE; FIBROBLAST GROWTH FACTORS; HISTOLOGICAL TECHNIQUES; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; RENAL DIALYSIS; TOMOGRAPHY, SPIRAL COMPUTED; TUNICA INTIMA; TUNICA MEDIA;

EID: 79955943073     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2010.5818     Document Type: Article

References (29)

1. London GM, Guerin AP, Marchais S, Metivier F, Pannnier B, Adda H. Arterial media calcification in end-stage renal disease: impact of all-cause and cardiovascular mortality. Nephrol Dial Transplant. 2003;18:1731-1740.
2. Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol. 2009;20:1453-1464.
3. Blacher J, Guerin AP, Pannier B, et al. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension. 2001;38, 938-942.
4. Agatston AS, Janowitz WR, Hildner FJ, et al. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990;15:827-832.
5. Bellasi A, Ferramosca E, Muntner P, et al. Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patients. Kidney Int. 2006;70:1623-1628.
6. Kidney Disease Improving Global Outcomes (KDIGO) CKDMBD Work Group. KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney disease: mineral and bone disorders (CKD-MBD). Kidney Int. 2009;76(Suppl 113):S1-S130.
7. Knez A, Becker A, Becker C, et al. Detection of coronary calcinosis with multislice spiral computerized tomography: an alternative to electron beam tomography. Z Kardiol. 2002;91:642-649.
8. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
9. Kauppila LI, Polak JF, Cupples LA, et al. New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25 year follow-up study. Atherosclerosis. 2004;132:245-250.
10. Moe SM, Duan D, Doehle BP, O'Neill KD, Chen NX. Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels. Kidney Int. 2003;63:1003-1011.
11. Gross M-L, Meyer H-P, Ziebart H, et al. Calcification of coronary intima and media: immunohistochemistry, backscatter imaging, and x-ray analysis in renal and nonrenal patients. Clin J Am Soc Nephrol. 2007;2:121-134.
12. Shanahan CM, Cary NR, Salisbury JR, Proudfoot D, Weissberg PL, Edmonds ME. Medial localization of mineralizationregulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation. 1999;100:2168-2176.
13. Goodman WG, London G, Amann K, et al. Vascular calcification in chronic renal disease. Am J Kidney Dis. 2004;43:572-579.
14. London GM, Marchais SJ, Guerin AP, Metivier F. Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia. Curr Opin Nephrol Hypertens. 2005;14:525-531.
15. Nakano T, Ninomiya T, Sumiyoshi S, Fet al. Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama Study. Am J Kidney Dis. 2009;55:21-30.
16. Schwarz U, Buzello M, Ritz E, et al. Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure. Nephrol Dial Transplant. 2000;15:218-223.
17. Robinson J, Tan AU, Wilensky RL, Matthai W, Munoz M, Rosas SE. Electron-beam computerized tomography correlates with coronary angiogram in chronic kidney disease patients. Am J Nephrol. 2007;27:247-252.
18. Sharples EJ, Pereira D, Summers S, et al. Coronary artery calcification measured with electron-beam computerized tomography correlates poorly with coronary artery angiography in dialysis patients. Am J Kidney Dis. 2004;43:313-319.
19. Jean G, Bresson E, Terrat JC, et al. Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol Dial Transplant. 2009;24:948-955.
20. Jean G, Terrat JC, Vanel T, et al. High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients. Nephrol Dial Transplant. 2009;24:2792-2796.
21. Gutierrez OM, Manstadt M, Isakova T, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med. 2008;359:584-592.
22. Coen G, Ballanti P, Silvestrini Get al. Immunohistochemical localization and mRNA expression of matrix Gla protein and fetuin-A in bone biopsies of hemodialysis patients. Virchows Arch. 2009;454:263-271.
23. Cottone S, Palermo A, Arsena R, et al. Relationship of fetuin- A with glomerular filtration rate and endothelial dysfunction in moderate-severe chronic kidney disease. J Nephrol. 2010;23,62-69.
24. Ketteler M, Wanner C, Metzger T, et al. Deficiencies of calcium- regulatory proteins in dialysis patients: a novel concept of cardiovascular calcification in uremia. Kidney Int Suppl. 2003;84:84-87.
25. Binkert C, Demetriou M, Sukhu B, Szweras M, Tenenbaum HC, Dennis JW: Regulation of osteogenesis by fetuin. J Biol Chem. 1999;274:28514-28520.
26. Coen G, Ballanti P, Balducci A, et al. Renal osteodystrophy: Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry. Am J Kidney Dis. 2006;48:106-113.
27. Wesseling-Perry K, Pereira RC, Wang H, et al. Relationship between plasma fibroblast growth factor-23 concentration and bone mineralization in children with renal failure on peritoneal dialysis. J Clin Endocrinol Metab. 2009;94:511-517.
28. Szweras M, Liu D, Partridge EA, et al. α2-HS glyco-protein/ fetuin, a transforming growth factor-/bone morpho-genetic protein antagonist, regulates postnatal bone growth and remodeling. J Biol Chem. 2002;22:19991-19997.
29. Sobue T, Gravely T, Hand A, et al. Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor s in human osteoblastic MG-63 cells. J Bone Miner Res. 2002;17:502-512.