Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery

Chang Gung Medical Journal

Volumn 34, Issue 2, 2011, Pages 172-178

  Liao, Chia Chih ^a   Chang, Chieh Szu ^a   Tseng, Chi Hao ^a   Sheen, Michael J ^a   Tsai, Shih Chang ^a   Chang, Yao Lung ^a   Wong, Shu Yam ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Diphenhydramine; Epidural morphine; Nalbuphine; Pruritus

Indexed keywords

DIPHENHYDRAMINE; MORPHINE; NALBUPHINE;

ADULT; ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; POSTOPERATIVE PAIN; PROPHYLAXIS; PRURITUS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; ANALGESIA, EPIDURAL; ANALGESIA, OBSTETRICAL; ANALGESICS, OPIOID; CESAREAN SECTION; DIPHENHYDRAMINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; MORPHINE; NALBUPHINE; PREGNANCY; PROSPECTIVE STUDIES; PRURITUS;

EID: 79955942730     PISSN: 20720939     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Chadwick HS, Ready LB. Subarachnoid and epidural morphine sulfate for postcesarean analgesia: a clinical comparison. Anesthesiology 1988;68:925-9.
2. Fuller JG, McMorland GH, Douglas MJ, Palmer L. Epidural morphine for analgesia after caesarean section: a report of 4880 patients. Can J Anaesth 1990;37:636-40.
3. Yeh HM, Chen LK, Lin CJ, Chan WH, Chen YP, Lin CS, Sun WZ, Wang MJ, Tsai SK. Prophylactic intravenous ondansetron reduces the incidence of subarachnoid morphine induced pruritus in patients undergoing cesarean delivery. Anesth Analg 2000;91:172-5.
4. Cohen SF, Ratner EF, Kreitzman TI, Archer JH, Mignano LR. Nalbuphine is better than naloxone for treatment of side effects after epidural morphine. Anesth Analg 199;75:747-52.
5. Kjellberg F, Tramer MR. Pharmacological control of opioid induced pruritus: a quantitative systematic review of randomized trials. Eur J Anaesthesiol 2001;18:346-57.
6. Szarvas S, Harmon D, Murphy D. Neuraxial opioid-induced pruritus: a review. J Clin Anesth 2003;15:234-9.
7. Siddik-Sayyid SM, Aouad MT, Taha SK, Azar MS, Hakki MA, Kaddoum RN, Nasr VG, Yazbek VG, Baraka AS. Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery? Anesth Analg 2007;104:421-4.
8. Bonnet MP, Marret E, Josserand J, Mercier FJ. Effect of prophylactic 5-HT3 receptor antagonists on pruritus induced by neuraxial opioids: a quantitative systematic review. Br J Anaesth 2008;101:311-9.
9. George RB, Allen TK, Habib AS. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine: A systematic review and meta-analysis. Anesth Analg 2009;109:174-82.
10. Rosow CE, Moss J, Philbin DM, Savarese JJ. Histamine release during morphine and fentanyl anesthesia. Anesthesiology 1982;56:93-6.
11. Eldor J, Fishlev V, Levine S, Guedj P, Dudakova I. Prevention of epidural morphine pruritus by intramuscular promethazine in parturients. Reg Anesth 1994;19:433-4.
12. Togashi Y, Umeuchi H, Okano K. Antipruritic activity of the kappa-opioid receptor agonist, TRK- 820. Eur J Pharmacol 2002;435:259-64.
13. Kendrick WD, Woods AM, Daly MY, Birch RF, DiFazio C. Naloxone versus nalbuphine infusion for prophylaxis of epidural morphine-induced pruritus. Anesth Analg 1996;82:641-7.
14. Horta ML, Morejon LCL, Cruz AW, Santos GR, Welling LC, Terhorst L, Costa RC, Alam RUZ. Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. Br J Anaesth 2006;96:796-800.
15. Ramsay MA, Savage TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J 1974;2:656-9.
16. LaBella FS, Kim RS, Templeton J. Opiate receptor binding activity of 17-alpha estrogenic steroids. Life Sci 1978;23:1797-804.
17. Bromage PR. The price of intraspinal narcotic analgesia: basic constraints. Anesth Analg 1981;60:461-3.
18. Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage 2001;21:151-68.
19. Warwick JP, Kearns CF, Scott WE. The effect of subhypnotic doses of propofol on the incidence of pruritus after intrathecal morphine for caesarean section. Anaesthesia 1997;52:265-75.
20. Ikoma A, Rukwied R, Stander S, Steinhoff M, Miyachi Y, Schmelz M. Neurophysiology of pruritus: interaction of itch and pain. Arch Dermatol 2003;139:1475-8.
21. Pert CB, Snyder SH. Opiate receptor: demonstration in nervous tissue. Science 1973;179:1011-4.
22. Thomas DA, Williams GM, Iwata K, Kenshalo DR, Dubner R. The medullary dorsal horn: A site of action of morphine in producing facial scratching in monkeys. Anesthesiology 1993;79:548-54.
23. Ko MCH, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN. Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 2003;305:173-9.
24. Somrat C, Oranuch K, Ketchada U. Optimal dose of nalbuphine for treatment of intrathecal-morphine induced pruritus after caesarean section. J Obstet Gynaecol Res 1999;25:209-13.
25. Yeh YC, Lin TF, Chang HC, Chan WS, Wang YP, Lin CJ, Sun WZ. Combination of low-dose nalbuphine and morphine in patient-controlled analgesia decreases incidence of opioid-related side effects. J Formos Med Assoc 2009;108:548-53.
26. Hermens JM, Ebertz JM, Hanifin JM, Hirshman CA. Comparison of histamine release in skin mast cells induced by morphine, fentanyl and oxymorphone. Anesthesiology 1985;62:124-9.
27. Stander S, Gunzer M, Metze D, Luger T, Steinhoff M. Localization of micro-opioid receptor 1A on sensory nerve fibers in human skin. Regul Pept 2002;31:110:75-83.
28. Waxler B, Dadabhoy ZP, Stojiljkovic l, Rabito SF. Primer of postoperative pruritus for anesthesiologists. Anesthesiology 2005;103:168-78.
29. Ballantyne JC, Loach AB, Carr DB. Itching after epidural and spinal opiates. Pain 1988;33:149-60.
30. Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage 2001;21:151-68.
31. Chaney MA. Side effects of intrathecal and epidural opioids. Can J Anaesth 1995;42:891-903.
32. Lo MW, Lee FH, Schary WL, Whitney CC. The pharmacokinetics of intravenous, intramuscular, and subcutaneous nalbuphine in healthy subjects. Eur J Clin Pharmacol 1987;33:297-301.