Synthesis of some novel 2, 3-disubstituted quinazolinone derivatives as analgesic and anti-inflammatory agents

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue 2, 2011, Pages 103-106

  Hemalatha, K ^a   Girija, K ^a  

^a Government of Puducherry   (India)

Author keywords

Analgesic; Anti inflammatory; Benzoxazine; Quinazolinone

Indexed keywords

2 METHYL 3 (2 METHYLPHENYL)QUINAZOLIN 4 (3H) ONE; 2 METHYL 4H BENZOXAZINE 4 ONE; 2 PHENYL 4H BENZOXAZINE 4 ONE; 3 (2 METHYLPHENYL) 2 PHENYLQUINAZOLIN 4 (3H) ONE; 3 AMINO 2 PHENYLQUINAZOLIN 4 (3H) ONE; 6 BROMO 3 (2 METHYLPHENYL) 2 PHENYLQUINAZOLIN 4 (3H) ONE; 8 DIBROMO 2 METHYL 3 (2 METHYLPHENYL)QUINAZOLIN 4 (3H) ONE; 8 DIBROMO 3 (2 METHYLPHENYL) 2 PHENYLQUINAZOLIN 4 (3H) ONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DICLOFENAC; N (2 METHYL 4 OXOQUINAZOLIN 3 (4H) YL) PYRIDINE 4 CARBOXAMIDE; N (4 OXO 2 PHENYLQUINAZOLIN 3 (4H) YL) DIBENZAMIDE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79955942262     PISSN: 09751491     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. K. R. Desai, J.A. Patel, B.D. Mistry. Synthesis and antimicrobial activity of Newer Quinazolinones. E. Journal of chem. 2006; 3(11): 97-102.
2. N. M. Raghavendra, P. P. Thampi, P.M. GurubasavarajaSswamy. Synthesis and anti-microbial activity of some Novel substituted piperazinyl-quinazolin-3(4H)-ones. E. Journal of chem. 2008: 5(1): 23-33.
3. Du-Jong Baek, Tae-Beom Kang, Hyun Ju Kim., Synthesis of Nonclassical Quinazolinone antifolates as thymidylate synthase inhibitors and their antitumor activity invitro. Korean Chem. Soc., 2004; 25(12): 1898-1906.
4. S. Jantova A, Repicky E, Paulovicova S, Letasiova L, Cipak. Ant proliferative activity and Apoptosis induced by 6-bromo-2-(morpholin-1-yl)-4-anilinoquinazoline on cells of Leukemia lines. Exp Oncol., 2008; 30 (2): 139-142.
5. B. Kiruthiga, K. Ilango, P. Valentina, N. Umarani and Ritesh Patel. Synthesis of some 2-substituted quinazolin-4-one derivatives and their biological activities. Int. J. Pharm Tech Res., 2009; 1(4): 1503-1506.
6. S. K. Sahu, Md. Afzal Azam, M. Banerjee, S. Acharya, C. C. Behera, Synthesis, characterization and biological activity of 2-methyl-3-amino quinazoline-4-(3H)-ones Schiff bases, J. Braz. Chem. Soc., 2008; 19(5): 963-970.
7. Molamas, M. S, Miller, J. J. Med. Chem., 1991; 3: 1492.
8. M.A. Al-Omar, Adel S. El-azan, H.A. El-obeid and S.G. Abdel Hamide. J. Saudi Chem. Soc., 2006; 10: 113.
9. S.N. Pandeya, D. Sriram, G. Nath, E. DeClercq. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methyl mercapto quinazolin-4-(3H)-one. Pharmaceutica Acta Helvetiae. 1999; 74: 11-17.
10. S.M. Mosaad, K.I. Mohammed, M.A. Ahmed, S.G. Abdel Hamid, Synthesis of certain New 6-Iodo quinazolines as potential antitubercular agents, Journal of Applied Sciences, 2004; 4(2): 302-307.
11. R. Kumar, T.K. Gupta and Surendra S. Parmar, The synthesis of quinazolone azomethines using CNS depressant activity. Indian J. Pharm., 1970; 33: 108.
12. Abdel Ghany Aly El-Helby and Mohammed Hemeda Abdel Wahab. Design and synthesis of some new derivatives of 3H-quinazolin-4-one with promising anticonvulsant activity. Acta Pharm., 2003; 53: 127-138.
13. Tiwari. S. S. and Pandy VK. J. Ind. Chem. Soc., 1975; 52: 736.
14. J. Van Ryn and R. M. Botting. New insights into the mode of action of anti-inflammatory drugs. Inflamm. Res, 1995; 44: 1-10.
15. J. Van Ryn, G. Trummlitz and M. Pairet. COX-2 selectivity and inflammatory processes. Curr. Med. Chem., 2000; 7: 1145-1161.
16. A.E. Abdel-Rahman, E. A. Bakhite and E. A. Al-Taifi. Synthesis and anti-microbial testing of some new S. Substituted thiopyridines, thienopyridines, pyridothienopyrimidines and pyridothienotriazines. Pharmazine, 2003; 58: 372-377.
17. R. V. Chambhare, B. G. Khadse, A. S. Bobde and R.H. Bahekar. Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno [2, 3-d] pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno [2, 3-d] pyrimidin-4-ones as anti-microbial agents. Eur. J. Med. Chem., 2003; 38: 89-100.
18. Girija K, Selvam P and Nagarajan R, Synthesis, anticancer activity of 3-[5-Amino-6-(2, 3-dichlorophenyl)-[1, 2, 4] triazin-3-yl]-6, 8-dibromo-2-substituted-3H-quinazolin-4-one. Asian J. Chem., 2005; 17: 1111-1115.
19. Chen MJ, Shimada T, Moulton AD, Harrison M, Nienhuis AW. Intonless human Dihydrofolate Reductase genes are derived from processes RNA molecules. Proc. Natl. Acad. Sci., 1982; 79 (23): 7435-7439.
20. S. Palanichamy and S. Nagarajan, J. Ethanopharmacol., 1990; 29: 73.
21. Kulkarni, S. K, In Hand book of Experimental Pharmacology, Vallabh prakashan, Delhi 3rd edn, (2007), 43.