Sirolimus damages podocytes in rats with protein overload nephropathy

Journal of Nephrology

Volumn 24, Issue 3, 2011, Pages 307-312

  Cai, Yong ^a   Chen, Yan ^a   Zheng, Shaoling ^a   Chen, Bicheng ^a   Yang, Yirong ^a   Xia, Peng ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Losartan; Podocyte; Proteinuria; Sirolimus

Indexed keywords

DESMIN; LOSARTAN; PROTEIN; RAPAMYCIN; SERUM ALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ACTIVITY; ELECTRON MICROSCOPY; FEMALE; IMMUNOHISTOCHEMISTRY; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; NEPHROTOXICITY; NONHUMAN; PODOCYTE; PROTEIN EXPRESSION; PROTEIN OVERLOAD NEPHROPATHY; PROTEINURIA; RAT; UPREGULATION; URINALYSIS; URINARY EXCRETION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BIOLOGICAL MARKERS; DESMIN; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LOSARTAN; PODOCYTES; PROTEINURIA; RATS; RATS, WISTAR; SIROLIMUS; UP-REGULATION;

EID: 79955939772     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/JN.2010.5817     Document Type: Article

References (26)

1. de Mattos A.M, Olyaei A.J, Bennett W.M. Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. Am J Kidney Dis. 2000;35:333-346.
2. Stephany B.R, Augustine J.J, Krishnamurthi V, et al. Differences in proteinuria and graft function in de novo sirolimus-based vs. calcineurin inhibitor-based immunosuppression in live donor kidney transplantation. Transplantation. 2006;82:368-374.
3. Aliabadi A.Z, Pohanka E, Seebacher G, et al. Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. Am J Transplant. 2008;8:854-861.
4. Bumbea V, Kamar N, Ribes D, et al. Long-term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus. Nephrol Dial Transplant. 2005;20:2517-2523.
5. Letavernier E, Bruneval P, Mandet C, et al. High sirolimus levels may induce focal segmental glomerulosclerosis de novo. Clin J Am Soc Nephrol. 2007;2:326-333.
6. Cho M.E, Hurley J.K, Kopp J.B. Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicity. Am J Kidney Dis. 2007;49:310-317.
7. Dittrich E, Schmaldienst S, Soleiman A, Hörl W.H, Pohanka E. Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurininhibitor therapy. Transpl Int. 2004;17:215-220.
8. Remuzzi A, Puntorieri S, Battaglia C, Bertani T, Remuzzi G. Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat. J Clin Invest. 1990;85:541-549.
9. Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 2006;116:288-296.
10. Gonlusen G, Ergin M, Payda S, Tunali N. The expression of cytoskeletal proteins (α-SMA, vimentin, desmin) in kidney tissue: a comparison of fetal, normal kidneys, and glomerulonephritis. Int Urol Nephrol. 2001;33:299-305.
11. Attia D.M, Feron O, Goldschmeding R, et al. Hypercholesterolemia in rats induces podocyte stress and decreases renal cortical nitric oxide synthesis via an angiotensin II type 1 receptor- sensitive mechanism. J Am Soc Nephrol. 2004;15:949-957.
12. Ruiz J.C, Campistol J.M, Sánchez-Fructuoso A, et al. Increase of proteinuria after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft dysfunction. Nephrol Dial Transplant. 2006;21:3252-3257.
13. Diekmann F, Campistol J.M. Conversion from calcineurin inhibitors to sirolimus in chronic allograft nephropathy: benefits and risks. Nephrol Dial Transplant. 2006;21:562-568.
14. Eddy A.A. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol. 1989;135:719-731.
15. Lemley K.V. Glomerular size selectivity during protein overload in the rat. Am J Physiol Renal Physiol. 1993;264:1046-1051.
16. Alvarez V, Quiroz Y, Nava M, Pons H, Rodríguez-Iturbe B. Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells. Am J Physiol Renal Physiol. 2002;283:1132-1141.
17. Coombes J.D, Mreich E, Liddle C, Rangan G.K. Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy. Kidney Int. 2005;68:2599-2607.
18. Shankland S.J. The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 2006;69:2131-2147.
19. Nosaka H, Tamura Y, Kojima K, Uchida S, Nagase M. Podocyte foot process effacement in very early phase of passive Heymann nephritis is not a prerequisite for proteinuria. J Nephrol. 2009;22:484-490.
20. Zou J, Yaoita E, Watanabe Y, et al. Upregulation of nestin, vimentin and desmin in rat podocytes in response to injury. Virchows Arch. 2006;448:485-492.
21. Kawachi H, Han G.D, Miyauchi N, Hashimoto T, Suzuki K, Shimizu F. Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy. J Nephrol. 2009;22:450-456.
22. Lapinski R, Perico N, Remuzzi A, Sangalli F, Benigni A, Remuzzi G. Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney. J Am Soc Nephrol. 1996;7:653-660.
23. Bonnet F, Cao Z, Cooper M.E. Apoptosis and angiotensin II: yet another renal regulatory system? Exp Nephrol. 2001;9:295-300.
24. Liang X.B, Ma L.J, Naito T, et al. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol. 2006;17:1886-1895.
25. Powers J.F, Tischler A.S, Cherington V. Discordant effects of rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells. Neurosci Lett. 1999;259:137-140.
26. Zhu J, Wu J, Frizell E, et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology. 1999;117:1198-1204.