Cross-linking of CD137 ligand modulates immune responses of thioglycollate-elicited mouse peritoneal macrophages

Inflammation Research

Volumn 60, Issue 5, 2011, Pages 467-473

  Bae, Jun Sang ^a   Kim, Hyeong Sup ^a   Park, Jae Hong ^a   Park, Sang Hyuk ^a   Lee, Hyeon Woo ^a  

^a Kyung Hee University   (South Korea)

Author keywords

CD137L; Peritoneal macrophages; Reverse signal; Thioglycollate; TNF

Indexed keywords

CD137 LIGAND; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; THIOGLYCOLIC ACID;

ANIMAL CELL; ARTICLE; C57BL 6 MOUSE; CELL COUNT; CONTROLLED STUDY; CROSS LINKING; FLOW CYTOMETRY; IMMUNOMODULATION; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION;

4-1BB LIGAND; ANIMALS; CROSS-LINKING REAGENTS; DOWN-REGULATION; FLOW CYTOMETRY; IMMUNE SYSTEM; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; THIOGLYCOLATES;

EID: 79955937102     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0289-y     Document Type: Article

References (32)

1. Mueller DL, Jenkins MK, Schwarz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol. 1989;7:445-80. (Pubitemid 19138020)
2. Weinberg AD, Vella AT, Croft M. Ox-40: life beyond the effector T cell stage. Semin Immunol. 1998;10:471-80. (Pubitemid 28564376)
3. Lee HW, Park SJ, Choi BK, Kim HH, Nam KO, Kwon BS. 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J Immunol. 2002;169: 4882-8. (Pubitemid 35217152)
4. Gravestein LA, Borst J. Tumor necrosis factor receptor family members in the immune system. Semin Immunol. 1998;10:423-34. (Pubitemid 28564371)
5. Vinay DS, Kwon BS. Role of 4-1BB in immune regulation. Semin Immunol. 1998;10:481-9.
6. Kwon B, Moon CH, Seo SK, Kwon BS. 4-1BB: still in the midst of darkness. Mol Cells. 2000;30:119-26.
7. Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS. 4-1BB costimulatory signals preferentially induce CD8 T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med. 1997;186:47-55. (Pubitemid 27304846)
8. Tan JT, Ha J, Cho HR, Tucker-Burden C, Hendrix RC, Mittler RS, Pearson TC, Larsen CP. Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation. 2000;70:175-83. (Pubitemid 30490774)
9. Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellstrom KE, Mittler RS, Chen L. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997;3:682-5. (Pubitemid 27264981)
10. Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci USA. 2003;100:709-14. (Pubitemid 36126117)
11. Eissner G, Kolch W, Scheurich P. Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev. 2004;15:353-66. (Pubitemid 39140699)
12. Eissner G, Kirchner S, Lindner H, Kolch W, Janosch P, Grell M, Scheurich P, Andreesen R, Holler E. Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages. J Immunol. 2000;164:6193-8. (Pubitemid 30408797)
13. Schwarz H. Biological activities of reverse signal transduction through CD137 ligand. J Leukoc Biol. 2005;77:281-6. (Pubitemid 40289556)
14. Langstein J, Becke FM, Söllner L, Krause G, Brockhoff G, Kreutz M, Andreesen R, Schwarz H. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000;273:117-22. (Pubitemid 30426872)
15. Laderach D, Wesa A, Galy A. 4-1BB-ligand is regulated on human dendritic cells and induces the production of IL-12. Cell Immunol. 2003;226:37-44. (Pubitemid 38121296)
16. Langstein J, Michel J, Schwarz H. CD137 induces proliferation and endomitosis in monocytes. Blood. 1999;94:3161-8. (Pubitemid 29512724)
17. Schwarz H, Blanco F, Valbracht J, Kempis J, Lotz M. ILA, a member of the human NGF/TNF receptor family regulates T lymphocyte proliferation and survival. Blood. 1996;87:2839-45. (Pubitemid 26102233)
18. Michel J, Langstein J, Krammer P, Schwarz H. CD137-induced apoptosis is independent of CD95. Immunology. 1999;98:42-6. (Pubitemid 29425907)
19. Kwon BS, Hurtado JC, Lee ZH, Kwack KB, Seo SK, Choi BK, Koller BH, Wolisi G, Broxmeyer HE, Vinay DS. Immune responses in 4-1BB (CD137)-deficient mice. J Immunol. 2002;168:5483-90. (Pubitemid 34556126)
20. Saito K, Ohara N, Hotokezaka H, Fukumoto S, Yuasa K, Naito M, Fujiwar T, Nakayama K. Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis. J Biol Chem. 2004;279:13555-63. (Pubitemid 38468881)
21. Shin HH, Lee EA, Kim SJ, Kwon BS, Choi HS. A signal through 4-1BB ligand inhibits receptor for activation of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis by increasing interferon (IFN)-beta production. FEBS Lett. 2006;580:1601-6. (Pubitemid 43290358)
22. Kim DK, Lee SC, Lee HW. CD137 ligand-mediated reverse signals increase cell viability and cytokine expression in murine myeloid cells: involvement of mTOR/p70S6 kinase and Akt. Eur J Immunol. 2009;39:2617-28.
23. Pauly S, Broll K, Wittmann M, Giegerich G, Schwarz H. CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers. J Leukoc Biol. 2002;72:35-42.
24. Ju SW, Ju SG, Wang FM, Gu ZJ, Qiu YH, Yu GH, Ma HB, Zhang XG. A functional anti-human 4-1BB ligand monoclonal antibody that enhances proliferation of monocytes by reverse signaling of 4-1BBL. Hybrid Hybridomics. 2003;22:333-8.
25. Kim YJ, Li G, Broxmeyer HE. 4-1BB ligand stimulation enhances myeloid dendritic cell maturation from human umbilical cord blood CD34+ progenitor cells. J Hematother Stem Cell Res. 2002;11:895-903. (Pubitemid 36139770)
26. Lee SW, Park Y, So T, Kwon BS, Cheroutre H, Mittler R, Croft M. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008;9:917-26.
27. Jiang D, Chen Y, Schwarz H. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008;181:3923-32.
28. Jiang D, Yue PSE, Drenkard D, Schwarz H. Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells. 2008;26:2372-81.
29. Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Mahbub-Ul Latif AH, Neumann C, Soruri A. CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. Eur J Immunol. 2008;38:1024-32.
30. Niu L, Strahotin B, Hewes B, Zhang B, Zhang Y, Archer D, Spencer T, Dillehay D, Kwon B, Chen L, Vella AT, Mittler RS. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J Immunol. 2007;178:4194-213. (Pubitemid 46492370)
31. Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L. Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ea-transgenic mice. J Immunol. 2001;167: 2671-6. (Pubitemid 32768897)
32. Wang C, Lin GH, McPherson AJ, Watts TH. Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 2009;229:192-215.