Advances in translational neuropathic research: Example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome

Current Pain and Headache Reports

Volumn 15, Issue 3, 2011, Pages 207-214

  Sabia, Michael ^a,b   Hirsh, Robert A ^a,b   Torjman, Marc C ^a,b   Wainer, Irving W ^c   Cooper, Niti ^a,b   Domsky, Richard ^a,b   Goldberg, Michael E ^a,b  

^a UMDNJ Robert Wood Johnson Medical School at Camden   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

(R,S) Ketamine; (R,S) Norketamine; Complex regional pain syndrome; Cytochromes; Dehydronorketamine; Enantioselective; Hydroxylated metabolites; Neuropathic pain; NMDA receptor; Pharmacodynamics; Pharmacokinetics

Indexed keywords

KETAMINE; PHENCYCLIDINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANESTHETIC RECOVERY; ARTICLE; AUTONOMIC DYSFUNCTION; BLOOD BRAIN BARRIER; CHRONIC PAIN; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); COMPLEX REGIONAL PAIN SYNDROME; COMPLEX REGIONAL PAIN SYNDROME TYPE I; COMPLEX REGIONAL PAIN SYNDROME TYPE II; CONTINUOUS INFUSION; DELIRIUM; DIAGNOSTIC TEST; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG URINE LEVEL; ENANTIOSELECTIVITY; EVIDENCE BASED MEDICINE; HALLUCINATION; HUMAN; LOW DRUG DOSE; NERVE LESION; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENETICS; PHYSICAL EXAMINATION; SENSORY DEPRIVATION; TRANSLATIONAL RESEARCH; UNSPECIFIED SIDE EFFECT;

ANIMALS; COMPLEX REGIONAL PAIN SYNDROMES; DRUG EVALUATION, PRECLINICAL; HUMANS; KETAMINE; MODELS, BIOLOGICAL; PAIN MEASUREMENT; TRANSLATIONAL MEDICAL RESEARCH;

EID: 79955924602     PISSN: 15313433     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11916-011-0185-3     Document Type: Article

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