Dried blood spot assay for estimation of metronidazole concentrations in rats and its application in single animal drug pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 19, 2011, Pages 1713-1716

  Kole, Prashant Laxman ^a   Majithia, Rita ^a   Singh, Thakur Raghu Raj ^a   Garland, Martin J ^a   Migalska, Katarzyna ^a   Donnelly, Ryan F ^a   McElnay, James ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Ahlstrom 226; Dried blood spot; Metronidazole; Single animal pharmacokinetic study

Indexed keywords

AHLSTROM; CALIBRATION STANDARD; COEFFICIENT OF VARIATION; CONCENTRATION RANGES; CONTROL SAMPLES; DRIED BLOOD SPOT; DRIED BLOOD SPOTS; IN-VIVO; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; LIMIT OF QUANTIFICATIONS; METRONIDAZOLE; PHARMACOKINETIC STUDIES; RAT WHOLE BLOOD; SAMPLE COLLECTION; SINGLE ANIMAL PHARMACOKINETIC STUDY; STUDY SAMPLES; VALIDATED METHODS; VIVO STUDIES; WHOLE BLOOD;

ANIMALS; CALIBRATION; PHARMACOKINETICS; QUALITY CONTROL;

BLOOD;

METRONIDAZOLE; TINIDAZOLE;

ARTICLE; BLOOD ANALYSIS; CALIBRATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIMIT OF QUANTITATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

ANIMALS; BLOOD SPECIMEN COLLECTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; LEAST-SQUARES ANALYSIS; METRONIDAZOLE; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TINIDAZOLE;

ANIMALIA; RATTUS;

EID: 79955915130     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.03.060     Document Type: Article

References (16)

1. Walsh G.M., Ferrone R.A., Tsuchiya M., Woods E.F., Deland E.C. Am. J. Physiol. 1980, 239:H805.
2. Hendriksen C.F. ILAR J. 2002, 43(Suppl. S43-48).
3. Suyagh M.F., Kole P.L., Millership J., Collier P., Halliday H., McElnay J.C. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010, 878(9-10):769.
4. Barfield M., Spooner N., Lad R., Parry S., Fowles S. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2008, 870:32.
5. Donnelly R.F., Majithiya R., Singh T.R.R., Morrow D.I.J., Garland M.J., Demir Y.K., Migalska K., Elizabeth R., Gillen D., Scott C.J., Woolfson A.D. Pharm. Res. 2010, 28:41.
6. Mikolajewska P., Donnelly R.F., Garland M.J., Morrow D.I.J., Singh T.R.R., Iani V., Moan J., Juzeniene A. Pharm. Res. 2010, 27(10):2213.
7. Fujimoto T., Tawa R., Hirose S. Chem. Pharm. Bull. (Tokyo) 1989, 37:174.
8. Thomas A., Déglon J., Steimer T., Mangin P., Daali Y., Staub C. J. Sep. Sci. 2010, 33:873.
9. Mauriala T., Chauret N., Oballa R., Nicoll-Griffith D.A., Bateman K.P. Rapid Commun. Mass Spectrom. 2005, 19:1984.
10. Wibawa J.D., Shaw P.N., Barrett D.A. J. Chromatogr. B Biomed. Sci. Appl. 2001, 761:213.
11. Chen Q., Hou S., Zheng J., Bi Y., Li Y., Yang X., Cai Z., Song X. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 858:199.
12. Yu-Hsing T., Wang Y., Loyd Allen V., Donald D., Albersand M.K., Gorgin Int. J. Pharm. 1990, 61:119.
13. Suyagh M.F., Iheagwaram G., Kole P.L., Millership J., Collier P., Halliday H., McElnay J.C. Anal. Bioanal. Chem. 2010, 397:687.
14. The European Agency for the Evaluation of Medicinal Products ICH Harmonised Tripartite Guideline: Validation of Analytical Procedures: Methodology. ICH Topic Q2B (CPMP/ICH/281/95) 1996, The European Agency for the Evaluation of Medicinal Products, London.
15. Windberger U., Bartholovitsch A., Plasenzotti R., Korak K.J., Heinze G. Exp. Physiol. 2003, 88:431.
16. Buttar H.S., Siddiqui W.H. Arch. Int. Pharmacodyn. Ther. 1980, 245:4.