-
1
-
-
77957750184
-
DPP-4 inhibitors: What may be the clinical differentiators?
-
Gerich, J. DPP-4 inhibitors: what may be the clinical differentiators? Diabetes Res Clin Pract 2010, 90(2): 131-40.
-
(2010)
Diabetes Res Clin Pract
, vol.90
, Issue.2
, pp. 131-140
-
-
Gerich, J.1
-
2
-
-
84878692592
-
-
Clinical.Trials.gov Web site, Accessed February 7, 2011
-
Clinical.Trials.gov Web site, http://clinicaltrials.gov/ct2/results?term= dutogliptin. Accessed February 7, 2011.
-
-
-
-
3
-
-
84878734697
-
-
PPD, Inc., April 26, Accessed February 4, 2011
-
PPD confirms Takeda receives NDA approval of Nesina® (alogliptin) from Japanese Ministry of Health, Labour and Welfare [news release]. PPD, Inc., April 26, 2010. http://investor.ppdi.com/releasedetail.cfm?ReleaseID=463452. Accessed February 4, 2011.
-
(2010)
PPD Confirms Takeda Receives NDA Approval of Nesina® (Alogliptin) from Japanese Ministry of Health, Labour and Welfare [News Release]
-
-
-
4
-
-
41949103059
-
Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes
-
Deacon, C.F. Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs 2008, 9(4): 402-13.
-
(2008)
Curr Opin Investig Drugs
, vol.9
, Issue.4
, pp. 402-413
-
-
Deacon, C.F.1
-
5
-
-
79952276785
-
Alogliptin: A novel molecule for improving glycemic control in type II diabetes mellitus
-
Ghatak, S.B., Patel, D.S., Shanker, N., Srivstava, A., Deshpande, S.S., Panchal, S.J. Alogliptin: a novel molecule for improving glycemic control in type II diabetes mellitus. Curr Diabetes Rev 2010, 6(6): 410-21.
-
(2010)
Curr Diabetes Rev
, vol.6
, Issue.6
, pp. 410-421
-
-
Ghatak, S.B.1
Patel, D.S.2
Shanker, N.3
Srivstava, A.4
Deshpande, S.S.5
Panchal, S.J.6
-
6
-
-
33846006173
-
The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker, D.J., Nauck, M.A. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368(9548): 1696-705.
-
(2006)
Lancet
, vol.368
, Issue.9548
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
7
-
-
33746800119
-
Investigational treatments for type 2 diabetes mellitus: Exenatide and liraglutide
-
Gonzalez, C., Beruto, V., Keller, G., Santoro, S., Di Girolamo, G. Investigational treatments for type 2 diabetes mellitus: exenatide and liraglutide. Expert Opin Investig Drugs 2006, 15(8): 887-95.
-
(2006)
Expert Opin Investig Drugs
, vol.15
, Issue.8
, pp. 887-895
-
-
Gonzalez, C.1
Beruto, V.2
Keller, G.3
Santoro, S.4
Di Girolamo, G.5
-
8
-
-
0036312876
-
Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats
-
Sudre, B., Broqua, P., White, R.B. et al. Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes 2002, 51(5): 1461-9.
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1461-1469
-
-
Sudre, B.1
Broqua, P.2
White, R.B.3
-
9
-
-
0036724721
-
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: A euglycemic-hyperinsulinemic clamp study
-
Pospisilik, J.A., Stafford, S.G., Demuth, H.U., McIntosh, C.H., Pederson, R.A. Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Diabetes 2002, 51(9): 2677-83.
-
(2002)
Diabetes
, vol.51
, Issue.9
, pp. 2677-2683
-
-
Pospisilik, J.A.1
Stafford, S.G.2
Demuth, H.U.3
McIntosh, C.H.4
Pederson, R.A.5
-
10
-
-
79955911794
-
The role of DPP-IV inhibitors in type 2 diabetes: Saxagliptin, an efficacious and well-tolerated treatment option
-
White, J. The role of DPP-IV inhibitors in type 2 diabetes: Saxagliptin, an efficacious and well-tolerated treatment option. Advance PA 2010, 18(5): 24-31.
-
(2010)
Advance PA
, vol.18
, Issue.5
, pp. 24-31
-
-
White, J.1
-
11
-
-
75749088373
-
Medicinal chemistry of incretin mimetics and DPP-4 inhibitors
-
Zettl, H., Schubert-Zsilavecz, M., Steinhilber, D. Medicinal chemistry of incretin mimetics and DPP-4 inhibitors. ChemMedChem 2010, 5(2): 179-85.
-
(2010)
ChemMedChem
, vol.5
, Issue.2
, pp. 179-185
-
-
Zettl, H.1
Schubert-Zsilavecz, M.2
Steinhilber, D.3
-
12
-
-
33947690115
-
Discovery of JANUVIA (sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
-
Thornberry, N.A., Weber, A.E. Discovery of JANUVIA (sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem 2007, 7(6): 557-68.
-
(2007)
Curr Top Med Chem
, vol.7
, Issue.6
, pp. 557-568
-
-
Thornberry, N.A.1
Weber, A.E.2
-
13
-
-
78650513267
-
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes
-
Deng, J., Peng, L., Zhang, G. et al. The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes. Eur J Med Chem 2010, 46(1): 71-6.
-
(2010)
Eur J Med Chem
, vol.46
, Issue.1
, pp. 71-76
-
-
Deng, J.1
Peng, L.2
Zhang, G.3
-
14
-
-
77955456705
-
Pharmacokinetics of dipeptidylpeptidase-4 inhibitors
-
Scheen, A.J. Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab 2010, 12(8): 648-58.
-
(2010)
Diabetes Obes Metab
, vol.12
, Issue.8
, pp. 648-658
-
-
Scheen, A.J.1
-
15
-
-
77955453343
-
Dipeptidylpeptidase-4 inhibitors (gliptins): Focus on drug-drug interactions
-
Scheen, A.J. Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet 2010, 49(9): 573-88.
-
(2010)
Clin Pharmacokinet
, vol.49
, Issue.9
, pp. 573-588
-
-
Scheen, A.J.1
-
16
-
-
41649102998
-
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
-
Christopher, R., Covington, P., Davenport, M., Fleck, P., Mekki, Q.A., Wann, E.R., Karim, A. Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects. Clin Ther 2008, 30(3): 513-27.
-
(2008)
Clin Ther
, vol.30
, Issue.3
, pp. 513-527
-
-
Christopher, R.1
Covington, P.2
Davenport, M.3
Fleck, P.4
Mekki, Q.A.5
Wann, E.R.6
Karim, A.7
-
17
-
-
73649128872
-
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: A two-phase, crossover study in healthy subjects
-
Karim, A., Covington, P., Christopher, R. et al. Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects. Int J Clin Pharmacol Ther 2010, 48(1): 46-58.
-
(2010)
Int J Clin Pharmacol Ther
, vol.48
, Issue.1
, pp. 46-58
-
-
Karim, A.1
Covington, P.2
Christopher, R.3
-
18
-
-
41649083174
-
Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: A randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes
-
Covington, P., Christopher, R., Davenport, M., Fleck, P., Mekki, Q.A., Wann, E.R., Karim, A. Pharmacokinetic, pharmacodynamic, and tolerability profiles of the dipeptidyl peptidase-4 inhibitor alogliptin: a randomized, double-blind, placebo-controlled, multiple-dose study in adult patients with type 2 diabetes. Clin Ther 2008, 30(3): 499-512.
-
(2008)
Clin Ther
, vol.30
, Issue.3
, pp. 499-512
-
-
Covington, P.1
Christopher, R.2
Davenport, M.3
Fleck, P.4
Mekki, Q.A.5
Wann, E.R.6
Karim, A.7
-
19
-
-
67649337808
-
Single-dose pharmacokinetics of the dipeptidyl peptidase-4 inhibitor alogliptin in subjects with renal impairment
-
68th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 6-10, San Francisco) 2008 Abst 538-P
-
Karim, A., Fleck, P., Hetman, L. Single-dose pharmacokinetics of the dipeptidyl peptidase-4 inhibitor alogliptin in subjects with renal impairment. Diabetes [68th Annu Meet Sci Sess Am Diabetes Assoc (ADA) (June 6-10, San Francisco) 2008] 2008, 57(Suppl. 1): Abst 538-P.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Karim, A.1
Fleck, P.2
Hetman, L.3
-
20
-
-
70549089727
-
Single-dose pharmacokinetics of alogliptin benzoate (SYR-322), a highly selective dipeptidyl peptidase-4 inhibitor, in subjects with moderate hepatic impairment
-
36th Annu Meet Am Coll Clin Pharmacol (ACCP) (September 9-11, San Francisco) 2007 Abst 107
-
Karim, A., Fleck, P., Dorsey, D., Zhang, W., Mekki, Q., Preston, R.A. Single-dose pharmacokinetics of alogliptin benzoate (SYR-322), a highly selective dipeptidyl peptidase-4 inhibitor, in subjects with moderate hepatic impairment. J Clin Pharmacol [36th Annu Meet Am Coll Clin Pharmacol (ACCP) (September 9-11, San Francisco) 2007] 2007, 47(9): Abst 107.
-
(2007)
J Clin Pharmacol
, vol.47
, Issue.9
-
-
Karim, A.1
Fleck, P.2
Dorsey, D.3
Zhang, W.4
Mekki, Q.5
Preston, R.A.6
-
21
-
-
84878684026
-
-
Web site Accessed February 7, 2011
-
ClinicalTrials.gov Web site. http://clinicaltrials.gov/ct2/results?term= alogliptin&phase=12&pg=1&show-flds=Y. Accessed February 7, 2011.
-
-
-
-
22
-
-
57649225147
-
Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomised, double-blind, placebo-controlled study
-
Nauck, M.A., Ellis, G.C., Fleck, P.R., Wilson, C.A., Mekki, Q. Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study. Int J Clin Pract 2009, 63(1): 46-55.
-
(2009)
Int J Clin Pract
, vol.63
, Issue.1
, pp. 46-55
-
-
Nauck, M.A.1
Ellis, G.C.2
Fleck, P.R.3
Wilson, C.A.4
Mekki, Q.5
-
23
-
-
70349314675
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
-
Pratley, R.E., Reusch, J.E., Fleck, P.R., Wilson, C.A., Mekki, Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 2009, 25(10): 2361-71.
-
(2009)
Curr Med Res Opin
, vol.25
, Issue.10
, pp. 2361-2371
-
-
Pratley, R.E.1
Reusch, J.E.2
Fleck, P.R.3
Wilson, C.A.4
Mekki, Q.5
-
24
-
-
79951699944
-
Initial combination therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes
-
Rosenstock, J., Inzucchi, S.E., Seufert, J., Fleck, P.R., Wilson, C.A., Mekki, Q. Initial combination therapy with alogliptin and pioglitazone in drug-naive patients with type 2 diabetes. Diabetes Care 2010, 33(11): 2406-8.
-
(2010)
Diabetes Care
, vol.33
, Issue.11
, pp. 2406-2408
-
-
Rosenstock, J.1
Inzucchi, S.E.2
Seufert, J.3
Fleck, P.R.4
Wilson, C.A.5
Mekki, Q.6
-
25
-
-
58149335320
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
-
Pratley, R.E., Kipnes, M.S., Fleck, P.R., Wilson, C., Mekki, Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. Diabetes Obes Metab 2009, 11(2): 167-76.
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.2
, pp. 167-176
-
-
Pratley, R.E.1
Kipnes, M.S.2
Fleck, P.R.3
Wilson, C.4
Mekki, Q.5
-
26
-
-
70450173642
-
Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia
-
Rosenstock, J., Rendell, M.S., Gross, J.L., Fleck, P.R., Wilson, C.A., Mekki, Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia. Diabetes Obes Metab 2009, 11(12): 1145-52.
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.12
, pp. 1145-1152
-
-
Rosenstock, J.1
Rendell, M.S.2
Gross, J.L.3
Fleck, P.R.4
Wilson, C.A.5
Mekki, Q.6
-
27
-
-
70350452161
-
Alogliptin use in elderly people: A pooled analysis from phase 2 and 3 studies
-
Pratley, R.E., McCall, T., Fleck, P.R., Wilson, C.A., Mekki, Q. Alogliptin use in elderly people: a pooled analysis from phase 2 and 3 studies. J Am Geriatr Soc 2009, 57(11): 2011-9.
-
(2009)
J Am Geriatr Soc
, vol.57
, Issue.11
, pp. 2011-2019
-
-
Pratley, R.E.1
McCall, T.2
Fleck, P.R.3
Wilson, C.A.4
Mekki, Q.5
-
30
-
-
72249116214
-
-
U.S. Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER) December Accessed February 7, 2011
-
U.S. Department of Health and Human Services. Food and Drug Administration. Center for Drug Evaluation and Research (CDER). Guidance for Industry. Diabetes Mellitus - Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. December 2008. http://www.fda.gov/ downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf. Accessed February 7, 2011.
-
(2008)
Guidance for Industry. Diabetes Mellitus - Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes
-
-
-
34
-
-
44949231427
-
Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus
-
CD006739
-
Richter, B., Bandeira-Echtler, E., Bergerhoff, K., Lerch, C.L. Dipeptidyl peptidase-4 (DPP-4) inhibitors for type 2 diabetes mellitus. Cochrane Database Syst Rev 2008(2): CD006739.
-
(2008)
Cochrane Database Syst Rev
, Issue.2
-
-
Richter, B.1
Bandeira-Echtler, E.2
Bergerhoff, K.3
Lerch, C.L.4
|