Validity of composite outcomes in meta-analyses of stroke prevention trials: The case of aspirin

Cerebrovascular Diseases

Volumn 32, Issue 1, 2011, Pages 22-27

  McGrath, Emer ^a   O'Conghaile, Aengus ^a   Eikelboom, John W ^b   Dinneen, Sean F ^a   Oczkowski, Colin ^b   O'Donnell, Martin J ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Aspirin; Composite outcome; Meta analysis; Stroke

Indexed keywords

ACETYLSALICYLIC ACID;

ARTICLE; BRAIN ISCHEMIA; HEART INFARCTION; HUMAN; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; RISK REDUCTION; SECONDARY PREVENTION; STROKE; TRANSIENT ISCHEMIC ATTACK; TREATMENT OUTCOME; VALIDITY;

ASPIRIN; HUMANS; MYOCARDIAL INFARCTION; OUTCOME ASSESSMENT (HEALTH CARE); PLATELET AGGREGATION INHIBITORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS; RISK FACTORS; STROKE; TREATMENT OUTCOME;

EID: 79955888756     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000324629     Document Type: Article

References (24)

1. O'Donnell MJ, Hankey GJ, Eikelboom JW: Antiplatelet therapy for secondary prevention of noncardioembolic ischemic stroke: a critical review. Stroke 2008; 39: 1638-1646.
2. Algra A, van Gijn J: Aspirin at any dose above mg offers only modest protection after cerebral ischaemia. J Neurol Neurosurg Psychiatry 1996; 60: 197-199. (Pubitemid 26044196)
3. Algra A, van Gijn J: Cumulative meta-analysis of aspirin efficacy after cerebral ischaemia of arterial origin. J Neurol Neurosurg Psychiatry 1999; 66: 255. (Pubitemid 29103541)
4. Albers GW, Amarenco P, Easton JD, Sacco RL, Teal P: Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133(6 suppl):630S-669S. (Pubitemid 351892974)
5. Ferreira-González I, Busse JW, Heels-Ansdell D, Montori VM, Akl EA, Bryant DM, Alonso-Coello P, Alonso J, Worster A, Upadhye S, Jaeschke R, Schünemann HJ, Permanyer- Miralda G, Pacheco-Huergo V, Domingo- Salvany A, Wu P, Mills EJ, Guyatt GH: Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ 2007; 334: 786.
6. Montori VM, Permanyer-Miralda G, Ferreira- González I, Busse JW, Pacheco-Huergo V, Bryant D, Alonso J, Akl EA, Domingo- Salvany A, Mills E, Wu P, Schünemann HJ, Jaeschke R, Guyatt GH: Validity of composite end points in clinical trials. BMJ 2005; 330: 594-596. (Pubitemid 40380357)
7. Antithrombotic Trialists' Collaboration: Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71-86.
8. Antiplatelet Trialists' Collaboration: Collaborative overview of randomised trials of antiplatelet therapy. 1. Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994; 308: 81-106.
9. Antithrombotic Trialists' (ATT) Collaboration, Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, Meade T, Patrono C, Roncaglioni MC, Zanchetti A: Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009; 373: 1849-1860.
10. Fields WS, Lemak NA, Frankowski RF, Hardy RJ: Controlled trial of aspirin in cerebral ischemia. Stroke 1977; 8: 301-314. (Pubitemid 8103607)
11. Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978; 299: 53-59.
12. Reuther R, Dorndorf W, Loew D: The treatment of transitory ischemic attacks with acetylsalicylic acid: results of a double-blind study (author's transl.) (in German). MMW Munch Med Wochenschr 1980; 122: 795-798. (Pubitemid 10102660)
13. Guiraud-Chaumeil B, Rascol A, David J, Boneu B, Clanet M, Bierme R: Prevention of recurrences of cerebral ischemic vascular accidents by platelet antiaggregants: results of a 3-year controlled therapeutic trial (in French). Rev Neurol (Paris) 1982; 138: 367-385.
14. Bousser MG, Eschwege E, Haguenau M, Lefaucconnier JM, Thibult N, Touboul D, Touboul PJ: AICLA controlled trial of aspirin and dipyridamole in the secondary prevention of athero-thrombotic cerebral ischemia. Stroke 1983; 14: 5-14. (Pubitemid 13174990)
15. Sorensen PS, Pedersen H, Marquardsen J, Petersson H, Heltberg A, Simonsen N, Munck O, Andersen LA: Acetylsalicylic acid in the prevention of stroke in patients with reversible cerebral ischemic attacks: a Danish cooperative study. Stroke 1983; 14: 15-22. (Pubitemid 13174991)
16. High-dose acetylsalicylic acid after cerebral infarction. A Swedish Cooperative Study. Stroke 1987; 18: 325-334.
17. UK-TIA Study Group: United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: interim results. Br Med J (Clin Res Ed) 1988; 296: 316-320.
18. Farrell B, Godwin J, Richards S, Warlow C: The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 1991; 54: 1044-1054.
19. SALT Collaborative Group: Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet 1991; 338: 1345-1349.
20. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143: 1-13. (Pubitemid 26402780)
21. Boysen G, Sorensen PS, Juhler M, Andersen AR, Boas J, Olsen JS, Joensen P: Danish verylow- dose aspirin after carotid endarterectomy trial. Stroke 1988; 19: 1211-1215.
22. Lindblad B, Persson NH, Takolander R, Bergqvist D: Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? A double-blind, placebo-controlled randomized trial. Stroke 1993; 24: 1125-1128. (Pubitemid 23237547)
23. EAFT (European Atrial Fibrillation Trial) Study Group: Secondary prevention in nonrheumatic atrial fibrillation after transient ischaemic attack or minor stroke. Lancet 1993; 342: 1255-1262.
24. Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, Meade TW: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow- up of five randomised trials. Lancet 2010; 376: 1741-1750.