Minoxidil activates β-catenin pathway in human dermal papilla cells: A possible explanation for its anagen prolongation effect

Journal of Dermatological Science

Volumn 62, Issue 3, 2011, Pages 154-159

  Kwack, Mi Hee ^a   Kang, Bo Mi ^a   Kim, Moon Kyu ^a   Kim, Jung Chul ^a   Sung, Young Kwan ^a  

^a Kyungpook National University School of Medicine   (South Korea)

Author keywords

Catenin; Anagen; Dermal papilla cell; Hair growth; Minoxidil

Indexed keywords

BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; LYMPHOID ENHANCER FACTOR 1; MEMBRANE PROTEIN; MINOXIDIL; PROTEIN AXIN2; PROTEIN EP2; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; HAIR CELL; HAIR FOLLICLE; HAIR GROWTH; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT DURATION;

ALOPECIA; ANIMALS; BETA CATENIN; BIOPSY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; HAIR FOLLICLE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MINOXIDIL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SKIN; VASODILATOR AGENTS;

EID: 79955878527     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.01.013     Document Type: Article

References (27)

1. Hardy M.H. The secret life of the hair follicle. Trends Genet 1992, 8:55-61.
2. Botchkarev V.A., Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc 2003, 8:46-55.
3. Stenn K.S., Paus R. Controls of hair follicle cycling. Physiol Rev 2001, 81:449-494.
4. Kaufman K.D. Androgens alopecia. Mol Cell Endocrinol 2002, 198:89-95.
5. Maretto S., Cordenonsi M., Dupont S., Braghetta P., Broccoli V., Hassan A.B., et al. Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 2003, 100:3299-3304.
6. Enshell-Seijffers D., Lindon C., Kashiwagi M., Morgan B.A. β-Catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell 2010, 18:633-642.
7. Kishimoto J., Burgeson R.E., Morgan B.A. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev 2000, 14:1181-1185.
8. Shimizu H., Morgan B.A. Wnt signaling through the β-catenin pathway is sufficient to maintain, but not restore, anagen-phase characteristics of dermal papilla cells. J Invest Dermatol 2004, 122:239-245.
9. Price V.H., Menefee E., Strauss P.C. Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. J Am Acad Dermatol 1999, 41:717-721.
10. Olsen E.A., Dunlap F.E., Funicella T., Koperski J.A., Swinehart J.M., Tschen E.H., et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 2002, 47:377-385.
11. Müller-Röver S., Handjiski B., van der Veen C., Eichmüller S., Foitzik K., McKay I.A., et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 2001, 117:3-15.
12. Fang X., Yu S.X., Lu Y., Bast R.C., Woodgett J.R., Mills G.B. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci USA 2000, 97:11960-11965.
13. Li M., Wang X., Meintzer M.K., Laessig T., Birnbaum M.J., Heidenreich K.A. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol 2000, 20:9356-9363.
14. Cross D.A., Alessi D.R., Vandenheede J.R., McDowell H.E., Hundal H.S., Cohen P. The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 1994, 303:21-26.
15. Shin H., Kwack M.H., Shin S.H., Oh J.W., Kang B.M., Kim A.A., et al. Identification of transcriptional targets of Wnt/beta-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a. J Dermatol Sci 2010, 8:91-96.
16. Zappacosta A.R. Reversal of baldness in patient receiving minoxidil for hypertension. N Engl J Med 1980, 303:1480-1481.
17. DeVillez R.L. The therapeutic use of topical minoxidil. Dermatol Clin 1990, 8:367-375.
18. Mori O., Uno H. The effect of topical minoxidil on hair follicular cycles of rats. J Dermatol 1990, 17:276-281.
19. Uno H., Cappas A., Brigham P. Action of topical minoxidil in the bald stump-tailed macaque. J Am Arch Dermatol 1987, 16:657-668.
20. Jun-Bo T., Zhuang-Qun Y., Xi-Jing H., Ying X., Yong S., Zhe X., et al. Effect of ethosomal minoxidil on dermal delivery and hair cycle of C57BL/6 mice. J Dermatol Sci 2007, 45:135-137.
21. Ikeda S., Kishida M., Matsuura Y., Usui H., Kikuchi A. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Oncogene 2000, 19:537-545.
22. Kitagawa M., Hatakeyama S., Shirane M., Matsumoto M., Ishida N., Hattori K., et al. An F-box protein FWD1, mediates ubiqitin-dependent proteolysis of beta-catenin. EMBO J 1999, 182:401-410.
23. Polakis P. Wnt signaling and cancer. Genes Dev 2000, 141:837-851.
24. Hurlstone A., Clevers H. T-cell factors: turn-ons and turn-offs. EMBO 2002, 21:2303-2311.
25. Michelet J.F., Commo S., Billoni N., Mahe Y.F., Bernard B.A. Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect. J Invest Dermatol 1997, 108:205-209.
26. Roenigk H. New topical agents for hair growth. Clin Dermatol 1988, 6:119-121.
27. Colombe L., Michelet J.F., Bernard B.A. Prostanoid receptors in anagen human hair follicles. Exp Dermatol 2007, 17:63-72.