Comparative analysis of transduced primary human dendritic cells generated by the use of three different lentiviral vector systems

Molecular Biotechnology

Volumn 47, Issue 3, 2011, Pages 262-269

  Grabski, Elena ^a   Waibler, Zoe ^b   Schüle, Silke ^b   Kloke, Björn Philipp ^b   Sender, Linda Y ^a   Panitz, Sylvia ^c   Cichutek, Klaus ^c   Schweizer, Matthias ^c   Kalinke, Ulrich ^a  

^a INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

^c Paul Ehrlich Institu   (Germany)

Author keywords

Human dendritic cells; Immune function; Lentiviral vectors; Transduction efficiency

Indexed keywords

BASIC RESEARCH; COMPARATIVE ANALYSIS; CYTOKINE RESPONSE; GENE TRANSFER VECTORS; GENETIC MODIFICATIONS; HUMAN CELLS; HUMAN DENDRITIC CELLS; IMMUNE FUNCTION; LENTIVIRAL VECTOR; LENTIVIRAL VECTORS; SIMIAN IMMUNODEFICIENCY VIRUS; T CELLS; TRANSDUCTION EFFICIENCY; VERSATILE TOOLS;

ANTIGEN-ANTIBODY REACTIONS; BACTERIOPHAGES; CELLS; GENE TRANSFER; GENES; VECTORS;

DISEASES;

ALPHA INTERFERON; HIV 2 ROD A DELTA ENV GFP VECTOR; LENTIVIRUS VECTOR; SIVMAC DELTA E EGFP VECTOR; SIVSMM PBJ DELTA E EGFP VECTOR; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RESPONSE; DENDRITIC CELL; DNA MODIFICATION; GENE TRANSFER; HUMAN; HUMAN CELL; PHAGOCYTOSIS; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; CELL CULTURE; CYTOLOGY; FLOW CYTOMETRY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; LENTIVIRINAE; METABOLISM; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 2; SIMIAN IMMUNODEFICIENCY VIRUS;

CELLS, CULTURED; DENDRITIC CELLS; FLOW CYTOMETRY; GENETIC VECTORS; HUMANS; LENTIVIRUS; PHAGOCYTOSIS; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 79955873990     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-010-9340-z     Document Type: Article

References (15)

1. Jonuleit, H., Tuting, T., Steitz, J., Bruck, J., Giesecke, A., Steinbrink, K., et al. (2000). Efficient transduction of mature CD83? dendritic cells using recombinant adenovirus suppressed T cell stimulatory capacity. Gene Therapy, 7, 249-254. (Pubitemid 30113774)
2. Chinnasamy, N., Treisman, J. S., Oaks, M. K., Hanson, J. P., & Chinnasamy, D. (2005). Ex vivo generation of genetically modified dendritic cells for immunotherapy: Implications of lymphocyte contamination. Gene Therapy, 12, 259-271. (Pubitemid 40220628)
3. Gruber, A., Kan-Mitchell, J., Kuhen, K. L., Mukai, T., & Wong- Staal, F. (2000). Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro. Blood, 96, 1327-1333. (Pubitemid 30658460)
4. Seeds, R. E., Gordon, S., & Miller, J. L. (2006). Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells. Immunobiology, 211, 525-535.
5. Reuter, S., Kaumanns, P., Buschhorn, S. B., & Dittmar, M. T. (2005). Role of HIV-2 envelope in Lv2-mediated restriction. Virology, 332, 347-358. (Pubitemid 40127254)
6. Muhlebach, M. D., Wolfrum, N., Schule, S., Tschulena, U., Sanzenbacher, R., Flory, E., et al. (2005). Stable transduction of primary human monocytes by simian lentiviral vector PBj. Molecular Therapy, 12, 1206-1216. (Pubitemid 41723055)
7. Liehl, B., Hlavaty, J., Moldzio, R., Tonar, Z., Unger, H., Salmons, B., et al. (2007). Simian immunodeficiency virus vector pseudotypes differ in transduction efficiency and target cell specificity in brain. Gene Therapy, 14, 1330-1343. (Pubitemid 47365619)
8. Schnell, T., Foley, P., Wirth, M., Munch, J., & Uberla, K. (2000). Development of a self-inactivating, minimal lentivirus vector based on simian immunodeficiency virus. Human Gene Therapy, 11, 439-447. (Pubitemid 30101953)
9. Goujon, C., Arfi, V., Pertel, T., Luban, J., Lienard, J., Rigal, D., et al. (2008). Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. Journal of Virology, 82, 12335-12345.
10. Schule, S., Kloke, B. P., Kaiser, J. K., Heidmeier, S., Panitz, S., Wolfrum, N., et al. (2009). Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj. PLoS One, 4, e7098.
11. Jonuleit, H., Kuhn, U., Muller, G., Steinbrink, K., Paragnik, L., Schmitt, E., et al. (1997). Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. European Journal of Immunology, 27, 3135-3142. (Pubitemid 28018007)
12. Mailliard, R. B., Wankowicz-Kalinska, A., Cai, Q., Wesa, A., Hilkens, C. M., Kapsenberg, M. L., et al. (2004). Alpha-type-1 polarized dendritic cells: A novel immunization tool with optimized CTL-inducing activity. Cancer Research, 64, 5934-5937. (Pubitemid 39129387)
13. Wolfrum, N., Muhlebach, M. D., Schule, S., Kaiser, J. K., Kloke, B. P., Cichutek, K., et al. (2007). Impact of viral accessory proteins of SIVsmmPBj on early steps of infection of quiescent cells. Virology, 364, 330-341. (Pubitemid 46873707)
14. Lane, P., Burdet, C., McConnell, F., Lanzavecchia, A., & Padovan, E. (1995). CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: Evidence for distinct activation requirements for antibody formation and B cell proliferation. European Journal of Immunology, 25, 1788-1793.
15. Connolly, J. B. (2002). Lentiviruses in gene therapy clinical research. Gene Therapy, 9, 1730-1734.