Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

Thrombosis and Haemostasis

Volumn 104, Issue 4, 2010, Pages 823-830

  Hindy François, Clemence ^a,b   Bachelot Loza, Christilla ^a   le Bonniec, Bernard ^a   Grelac, Francoise ^a   Dizier, Blandine ^a   Godier, Anne ^a,c   Emmerich, Joseph ^a,d   Gaussem, Pascale ^a,d   Samama, Charles Marc ^a,c,d  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c HÔTEL DIEU   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Aspirin; Bleeding; Clopidogrel; Rabbit; rFVIIa; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; PLACEBO; RECOMBINANT BLOOD CLOTTING FACTOR 7A; ANTITHROMBOCYTIC AGENT; BLOOD CLOTTING FACTOR 7A; DRUG DERIVATIVE; RECOMBINANT PROTEIN; TICLOPIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BLEEDING; BLEEDING TIME; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; RABBIT; THROMBIN TIME; THROMBOCYTE AGGREGATION; ANIMAL; BLOOD; BLOOD FLOW; CAROTID ARTERY; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; THROMBOSIS;

ANIMALS; ASPIRIN; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FACTOR VIIA; HEMORRHAGE; HUMANS; PLATELET AGGREGATION INHIBITORS; RABBITS; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; THROMBOSIS; TICLOPIDINE;

EID: 79955851527     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-01-0039     Document Type: Article

References (35)

1. Patrono C, Bachmann F, Baigent C, et al. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology. Eur Heart J 2004; 25: 166-181.
2. Gachet C. P2 receptors, platelet function and pharmacological implications. Thromb Haemost 2008; 99: 466-472.
3. Jones RL, Giembycz MA, Woodward DF. Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol 2009; 158: 104-145.
4. Herbert JM, Savi P. P2Y12, a new platelet ADP receptor, target of clopidogrel. Sem Vasc Med 2003; 3: 113-122.
5. Albaladejo P, Marret E, Piriou V, et al. Perioperative management of antiplatelet agents in patients with coronary stents: recommendations of a French Task Force. Br J Anaesth 2006; 97: 580-582.
6. Zeymer U, Gitt A, Junger C, et al. Clopidogrel in addition to aspirin reduces inhospital major cardiac and cerebrovascular events in unselected patients with acute ST segment elevation myocardial. Thromb Haemost 2008; 99: 155-160.
7. Hallas J, Dall M, Andries A, et al. Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based casecontrol study. Br Med J 2006; 333: 726
8. Tauber M, Koller H, Moroder P, et al. Secondary intracranial hemorrhage after mild head injury in patients with low-dose acetylsalicylate acid prophylaxis. J Trauma 2009; 67: 521-525.
9. Weant KA, Flynn JF, Akers WS. Management of antiplatelet therapy for minimization of bleeding risk before cardiac surgery. Pharmacotherapy 2006; 26: 1616-1625.
10. Lecompte T, Hardy JF. Antiplatelet agents and perioperative bleeding. Can J Anaesth 2006; 53 (6 Suppl): S103-112.
11. Samama CM, Djoudi R, Lecompte T, et al. Perioperative platelet transfusion: recommendations of the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSaPS) 2003. Can J Anaesth 2005; 52: 30-37.
12. Vilahur G, Choi BG, Zafar MU, et al. Normalization of platelet reactivity in clopidogrel-treated subjects. J Thromb Haemost 2007; 5: 82-90.
13. Roberts HR, Monroe DM, White GC. The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood 2004; 104: 3858-3864.
14. Pipe SW. Recombinant clotting factors. Thromb Haemost 2008; 99: 840-850.
15. Altman R, Scazziota A, M DELH, et al. Recombinant factor VIIa reverses the inhibitory effect of aspirin or aspirin plus clopidogrel on in vitro thrombin generation. J Thromb Haemost 2006; 4: 2022-2027.
16. Godier A, Mazoyer E, Cymbalista F, et al. Recombinant activated factor VII efficacy and safety in a model of bleeding and thrombosis in hypothermic rabbits: a blind study. J Thromb Haemost 2007; 5: 244-249.
17. Charbonneau S, Girard F, Boudreault D, et al. Recombinant human activated factor VII is thrombogenic in a rabbit model of cyclic flow reduction and does not reduce intra-abdominal bleeding. Thromb Haemost 2007; 97: 296-303.
18. Folts J, Rowe G. Cyclical reductions in coronary blood flow in coronary arteries with fixed partial obstruction and their inhibition with aspirin. Fed Proc 1974; 33: 413
19. Fattorutto M, Tourreau-Pham S, Mazoyer E, et al. Recombinant activated factor VII decreases bleeding without increasing arterial thrombosis in rabbits. Can J Anaesth 2004; 51: 672-679.
20. Delaporte-Cerceau S, Samama CM, Riou B, et al. Ketorolac and enoxaparin affect arterial thrombosis and bleeding in the rabbit. Anesthesiology 1998; 88: 1310-1317.
21. Louvain-Quintard VB, Bianchini EP, Calmel-Tareau C, et al. Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas. J Biol Chem 2005; 280: 41352-41359
22. Pusateri AE, Ryan KL, Delgado AV, et al. Effects of increasing doses of activated recombinant factor VII on haemostatic parameters in swine. Thromb Haemost 2005; 93: 275-283.
23. Martinowitz U, Holcomb JB, Pusateri AE, et al. Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine with grade V liver injuries. J Trauma 2001; 50: 721-729.
24. Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial. Lancet 2007; 370: 949-956.
25. Neubauer H, Lask S, Engelhardt A, et al. How to optimise clopidogrel therapy? Reducing the low-response incidence by aggregometry-guided therapy modification. Thromb Haemost 2008; 99: 357-362.
26. Zimmermann N, Hohlfeld T. Clinical implications of aspirin resistance. Thromb Haemost 2008; 100: 379-390.
27. Howes JL, Smith RS, Helmer SD, et al. Complications of recombinant activated human coagulation factor VII. Am J Surg 2009; 198: 895-899.
28. Diringer MN, Skolnick BE, Mayer SA, et al. Thromboembolic events with recombinant activated factor VII in spontaneous intracerebral hemorrhage: results from the Factor Seven for Acute Hemorrhagic Stroke (FAST) trial. Stroke 2010; 41: 48-53.
29. Bruckner BA, DiBardino DJ, Ning Q, et al. High incidence of thromboembolic events in left ventricular assist device patients treated with recombinant activated factor VII. J Heart Lung Transplant 2009; 28: 785-790.
30. Abshire T, Kenet G. Safety update on the use of recombinant factor VIIa and the treatment of congenital and acquired deficiency of factor VIII or IX with inhibitors. Haemophilia 2008; 14: 898-902.
31. Altman R, Scazziota A, Rouvier J, et al. Effect of sodium arachidonate on thrombin generation through platelet activation--inhibitory effect of aspirin. Thromb Haemost 2000; 84: 1109-1112.
32. Hedner U. Mechanism of action of recombinant activated factor VII: an update. Semin Hematol 2006; 43 (1 Suppl 1): S105-107.
33. Mayer SA, Brun NC, Begtrup K, et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med 2005; 352: 777-785.
34. O'Connell KA, Wood JJ, Wise RP, et al. Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. J Am Med Assoc 2006; 295: 293-298.
35. Sugg RM, Gonzales NR, Matherne DE, et al. Myocardial injury in patients with intracerebral hemorrhage treated with recombinant factor VIIa. Neurology 2006; 67: 1053-1055.