3,5-hydroxy-6,7,3′,4′-tetramethoxyflavone isolated from Laggera pterodonta induces CNE cell apoptosis

Progress in Biochemistry and Biophysics

Volumn 38, Issue 3, 2011, Pages 254-261

  Cao, Chang Shu ^a   Shen, Wei Zai ^a   Li, Yao Lan ^b   Wang, Hui ^a   Gao, Ming Ya ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

3, 5 Hydroxy 6, 7, 3 , 4 tetramethoxyflavone; Apoptosis; CNE cells; Mitochondria

Indexed keywords

LAGGERA PTERODONTA;

EID: 79955835201     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2010.00539     Document Type: Article

References (18)

1. Editorial Committee of Flora of China of Chinese Academy of Science. Flora of China (Vol. 75). Beijing: Science Press, 1979:46
2. Mei Z N, Li Y F, Yu X, et al. J South-Central University for Nationalities (Nat Sci Edition), 2005, 24(3):32-35
3. Yang G Z, Li Y F, Yu X, et al. Acta Pharm Sinica, 2007, 42(5):511-515
4. Liu B L, Zhang T, Zhang X Q, et al. Chin J Chinese Materia Madica, 2010, 35(5):602-606
5. Li-Weber M. New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Can Treat Rev, 2009, 35(1):57-68
6. Chang H L, Wu Y C, Su J H, et al. Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of P38 mitogen-activated protein kinase and C-Jun. Nh2-terminal kinase 1/2. Pharmaol Exp Ther, 2008, 325(3):841-849
7. Zhang Q, Zhao X H, Wang Z J. Cytoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cells line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro, 2009, 23(5):797-807
8. Tang W, Hemm I, Bertram B. Recent development of antitumor agents from Chinese herbral medicines; Part I. Low molecular compounds. Planta Med, 2003, 69(2):97-108 (Pubitemid 36384491)
9. Walle T, Ta N, Kawamori T, et al. Cancer chemopreventive properties of orally bioavailable favonoids-Methylated versus unmethylatedfavones. Biochem Pharm, 2007, 73(9):1288-1296 (Pubitemid 46452585)
10. Lo K W, To K F, Huang D P. Focus on nasopharyngeal carcinoma. Cancer Cell, 2004, 5(5):423-428 (Pubitemid 38612865)
11. Chou J, Lin Y, Kim J, et al. Nasopharyngeal carcinoma-review of the molecular mechanisms of tumorigenesis. Head Neck, 2008, 30(7):946-963 (Pubitemid 352008957)
12. Cho W C. Nasopharyngeal carcinoma: molecular biomarker discovery and progress. Molecular Cancer, 2007, 6:1-9
13. Baujat B, Audry H, Bourhis J, et al. Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. International J Radiation Oncology, 2006, 64(1):47-56 (Pubitemid 41831208)
14. Wang Y, He Q Y, Tsao S W, et al. Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization. Cancer Letter, 2008, 265(2):188-196
15. Cao C S, Shen W Z, Li Y L, et al. Chin J Phathophysiology, 2010, 26(7):1362-1365
16. Chou J, Lin Y C, Kim J, et al. Nasopharyngeal carcinoma-review of the molecular mechanisms of tumorigenesis. Head Neck, 2008, 30(7):946-963 (Pubitemid 352008957)
17. Jeong S Y, Seol D W. The role of mitochondria in apoptosis. BMB Reports, 2008, 41(1):11-22
18. Alison M, Adrian F, Nicola E, et al. The antipsoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, induces apoptosis through a pathway dependent on respiratory competent mitochondria. FASEB J, 2005, 19(8):1012-1014