MALDI mass spectrometric imaging of lipids in rat brain injury models

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 6, 2011, Pages 1014-1021

  Hankin, Joseph A ^a   Farias, Santiago E ^a   Barkley, Robert M ^a   Heidenreich, Kim ^a   Frey, Lauren C ^a   Hamazaki, Kei ^b   Kim, Hee Yong ^b   Murphy, Robert C ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Alkali metal adduct images; Brain; Brain injury; CA1; Ceramide; Hippocampus damage; Imaging mass spectrometry; IMS; Ischemia reperfusion; MALDI; Phosphatidylcholine; Sublimation; Traumatic brain injury

Indexed keywords

BRAIN INJURY; CA1; CERAMIDES; HIPPOCAMPUS DAMAGE; IMAGING MASS SPECTROMETRY; IMS; ISCHEMIA REPERFUSION; MALDI; PHOSPHATIDYLCHOLINE; TRAUMATIC BRAIN INJURIES;

AMIDES; BRAIN; CELL DEATH; DESORPTION; IONS; MOLECULAR STRUCTURE; PHOSPHOLIPIDS; SECONDARY ION MASS SPECTROMETRY; SPECTROMETRY; TISSUE;

BRAIN MODELS;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CERAMIDE; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN REGION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; EXTRACELLULAR FLUID; HIPPOCAMPAL CA1 REGION; LIPID ANALYSIS; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; RAT; REPERFUSION INJURY; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; CA1 REGION, HIPPOCAMPAL; DISEASE MODELS, ANIMAL; HISTOCYTOCHEMISTRY; MALE; MOLECULAR IMAGING; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

RATTUS;

EID: 79955829293     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0122-z     Document Type: Article

References (32)

1. DS Cornett ML Reyzer P Chaurand RM Caprioli 2007 MALDI Imaging Mass Spectrometry: Molecular Snapshots of Biochemical Systems Nat. Methods 4 828 833 10.1038/nmeth1094 1:CAS:528:DC%2BD2sXhtV2mtr7F (Pubitemid 350055580)
2. K Schwamborn RM Caprioli 2010 Molecular Imaging by Mass Spectrometry-Looking Beyond Classical Histology Nat. Rev. Cancer 10 639 646 10.1038/nrc2917 1:CAS:528:DC%2BC3cXhtVCmtbzO
3. S Koizumi S Yamamoto T Hayasaka Y Konishi M Yamaguchi-Okada N Goto-Inoue Y Sugiura M Setou H Namba 2010 Imaging Mass Spectrometry Revealed the Production of Lyso-Phosphatidylcholine in the Injured Ischemic Rat Brain Neuroscience 168 219 225 10.1016/j.neuroscience.2010.03.056 1:CAS:528:DC%2BC3cXmtFertLg%3D
4. M Wisztorski D Croix E Macagno I Fournier M Salzet 2008 Molecular MALDI Imaging: An Emerging Technology for Neuroscience Studies Dev Neurobiol. 68 845 858 10.1002/dneu.20623 1:CAS:528:DC%2BD1cXms1ehsbw%3D (Pubitemid 351620776)
5. DM Drexler TJ Garrett JL Cantone RW Diters JG Mitroka MC Prieto Conaway SP Adams RA Yost M Sanders 2007 Utility of Imaging Mass Spectrometry (IMS) by Matrix-Assisted Laser Desorption Ionization (MALDI) on an Ion Trap Mass Spectrometer in the Analysis of Drugs and Metabolites in Biological Tissues J. Pharmacol. Toxicol. Methods 55 279 288 10.1016/j.vascn.2006.11.004 1:CAS:528:DC%2BD2sXjsVGgsr4%3D (Pubitemid 46436524)
6. Y Sugiura Y Konishi N Zaima S Kajihara H Nakanishi R Taguchi M Setou 2009 Visualization of the Cell-Selective Distribution of PUFA-Containing Phosphatidylcholines in Mouse Brain by Imaging Mass Spectrometry J. Lipid Res. 50 1776 1788 10.1194/jlr.M900047-JLR200 1:CAS:528:DC%2BD1MXhtVCgsrbI
7. RC Murphy JA Hankin RM Barkley 2009 Imaging of Lipid Species by MALDI Mass Spectrometry J. Lipid Res. 50 S317 S322 10.1194/jlr.R800051-JLR200
8. E Astigarraga G Barreda-Gómez L Lombardero O Fresnedo F Castaño MT Giralt B Ochoa R Rodríguez-Puertas 2008 Fernández, JA. Profiling and Imaging of Lipids on Brain and Liver Tissue by Matrix-Assisted Laser Desorption/ Ionization Mass Spectrometry Using 2-Mercaptobenzothiazole as a Matrix Anal. Chem. 80 9105 9114 10.1021/ac801662n 1:CAS:528:DC%2BD1cXhtlSlsrfF
9. JM Deeley JA Hankin MG Friedrich RC Murphy RJ Truscott 2010 Mitchell T, W.; Blanksby, S. J. Sphingolipid Distribution Changes with Age in the Human Lens J. Lipid Res. 51 2753 2760 10.1194/jlr.M007716 1:CAS:528:DC%2BC3cXhtVOltr%2FI
10. AC Grey AK Gelasco J Section RA Moreno-Rodriguez EL Krug KL Schey 2010 Molecular Morphology of the Chick Heart Visualized by MALDI Imaging Mass Spectrometry Anat. Rec. (Hoboken) 293 821 828 1:CAS:528:DC%2BC3cXms1Olu7Y%3D
11. JA Hankin RC Murphy 2010 Relationship Between MALDI IMS Intensity and Measured Quantity of Selected Phospholipids in Rat Brain Sections Anal. Chem. 82 8476 8484 10.1021/ac101079v 1:CAS:528:DC%2BC3cXhtFygsb3M
12. KE Burnum DS Cornett SM Puolitaival SB Milne DS Myers S Tranguch HA Brown SK Dey RM Caprioli 2009 Spatial and Temporal Alterations of Phospholipids Determined by Mass Spectrometry During Mouse Embryo Implantation J. Lipid Res. 50 2290 2298 10.1194/jlr.M900100-JLR200 1:CAS:528:DC%2BD1MXhtlShurzM
13. LJ Sparvero AA Amoscato PM Kochanek BR Pitt VE Kagan H Bayir 2010 Mass-Spectrometry Based Oxidative Lipidomics and Lipid Imaging: Applications in Traumatic Brain Injury J. Neurochem. 115 1322 1336 10.1111/j.1471-4159.2010. 07055.x 1:CAS:528:DC%2BC3cXhs1aiur3P
14. LC Frey J Hellier C Unkart A Lepkin A Howard K Hasebroock N Serkova L Liang M Patel I Soltesz K Staley 2009 A Novel Apparatus for Lateral Fluid Percussion Injury in the Rat J. Neurosci. Methods 177 267 272 10.1016/j.jneumeth.2008.10.022
15. S Farias LC Frey RC Murphy KA Heidenreich 2009 Injury-Related Production of Cysteinyl-Leukotrienes Contributes to Brain Damage Following Experimental Traumatic Brain Injury J. Neurotrauma 26 1977 1986 10.1089/neu.2009.0877
16. BR Perri DH Smith H Murai G Sinson KE Saatman R Raghupathi RT Bartus TK McIntosh 1997 Metabolic Quantification of Lesion Volume Following Experimental Traumatic Brain Injury in the Rat J Neurotrauma 14 15 22 10.1089/neu.1997.14.15 1:STN:280:DyaK2s3gtVeksA%3D%3D (Pubitemid 27100277)
17. SJ Spencer RN Auer QJ Pittman 2006 Rat Neonatal Immune Challenge Alters Adult Responses to Cerebral Ischaemia J. Cereb. Blood Flow Metab. 26 456 467 10.1038/sj.jcbfm.9600206
18. JA Hankin RM Barkley RC Murphy 2007 Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging J. Am. Soc. Mass Spectrom. 18 1646 1652 10.1016/j.jasms.2007.06.010 1:CAS:528:DC%2BD2sXps1Gksr8%3D (Pubitemid 47302327)
19. JC Jurche SS Rubakhin JV Sweedler 2005 MALDI-MS Imaging of Features Smaller than the Size of the Laser Beam J. Am. Soc. Mass Spectrom. 16 1654 1659 10.1016/j.jasms.2005.06.006 (Pubitemid 41345157)
20. T Kirino 1982 Delayed Neuronal Death in the Gerbil Hippocampus Following Ischemia Brain Res. 239 57 69 10.1016/0006-8993(82)90833-2 1:STN:280: DyaL383jt12lsQ%3D%3D (Pubitemid 12101768)
21. WA Pulsinelli JB Brierley F Plum 1982 Temporal Profile of Neuronal Damage in a Model of Transient Forebrain Ischemia Ann. Neurol. 11 491 498 10.1002/ana.410110509 1:STN:280:DyaL383lsFaisw%3D%3D (Pubitemid 12158810)
22. CK Petito E Feldmann WA Pulsinelli F Plum 1987 Delayed Hippocampal Damage in Humans Following Cardiorespiratory Arrest Neurology 37 1281 1286 1:STN:280:DyaL2s3oslOluw%3D%3D
23. S Zola-Morgan LR Squire DG Amaral 1986 Human Amnesia and the Medial Temporal Region: Enduring Memory Impairment Following a Bilateral Lesion Limited to Field CA1 of the Hippocampus J. Neurosci. 6 2950 2967 1:STN:280: DyaL2s%2FhtVyjtg%3D%3D (Pubitemid 16026076)
24. Murphy, R. C.; Axelsen, P. H.: Mass Spectrometric Analysis of Long-Chain Lipids. Mass Spectrom. Rev. 2010, in press.
25. M Nakane M Kubota T Nakagomi A Tamura H Hisaki H Shimasak N Ueta 2000 Lethal Forebrain Ischemia Stimulates Sphingomyelin Hydrolysis and Ceramide Generation in the Gerbil Hippocampus Neurosci. Lett. 296 89 92 10.1016/S0304-3940(00)01655-4 1:CAS:528:DC%2BD3cXosFCjsLo%3D
26. SN Jackson M Ugarov JD Post T Egan D Langlais JA Schultz AS Woods 2008 A Study of Phospholipids by Ion Mobility TOFMS J. Am. Soc. Mass Spectrom. 19 1655 1662 10.1016/j.jasms.2008.07.005 1:CAS:528:DC%2BD1cXhtlOhtLfF
27. SN Jackson HY Wang AS Woods 2007 In Situ Structural Characterization of Glycerophospholipids and Sulfatides in Brain tissue using MALDI-MS/MS J. Am. Soc. Mass Spectrom. 18 17 26 10.1016/j.jasms.2006.08.015 1:CAS:528: DC%2BD2sXlsFCqtQ%3D%3D (Pubitemid 46038161)
28. Y Chen J Allegood Y Liu E Wang B Cachón-Gonzalez TM Cox AH Merrill Jr MC Sullards 2008 Imaging MALDI Mass Spectrometry Using an Oscillating Capillary Nebulizer Matrix Coating System and Its Application to Analysis of Lipids in Brain from a Mouse Model of Tay-Sachs/Sandhoff Disease Anal. Chem. 80 2780 2788 10.1021/ac702350g 1:CAS:528:DC%2BD1cXis1Gitbw%3D (Pubitemid 351556439)
29. ML Vestal 2009 Modern MALDI Time-of-Flight Mass Spectrometry J. Mass Spectrom. 44 303 317 10.1002/jms.1537 1:CAS:528:DC%2BD1MXktVSqsbg%3D
30. M Kubota K Narita T Nakagomi A Tamura H Shimasaki N Ueta S Yoshida 1996 Sphingomyelin Changes in Rat Cerebral Cortex During Focal Ischemia Neurol. Res. 18 337 341 1:CAS:528:DyaK28XlslKhs70%3D (Pubitemid 26292134)
31. K Taya CR Marmarou K Okuno R Prieto A Marmarou 2010 Effect of Secondary Insults Upon Aquaporin-4 Water Channels Following Experimental Cortical Contusion in Rats J. Neurotrauma 27 229 239 10.1089/neu.2009.0933
32. R Durmaz G Kanbak F Akyüz S Isiksoy F Yücel M Inal E Tel 2003 Lazaroid Attenuates Edema by Stabilizing ATPase in the Traumatized Rat Brain Can. J. Neuro. Sci. 30 143 149 (Pubitemid 36717997)