Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat

Journal of Neurotrauma

Volumn 14, Issue 1, 1997, Pages 15-22

  Perri, Brian R ^a   Smith, Douglas H ^a   Murai, Hisayuki ^a   Sinson, Grant ^a   Saatman, Kathryn E ^a   Raghupathi, Ramesh ^a   Bartus, Raymond T ^b   McIntosh, Tracy K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALKERMES INC   (United States)

Author keywords

brain injury; histopathology; lateral fluid percussion; lesion volume; metabolism; TTC

Indexed keywords

TRIPHENYLTETRAZOLIUM;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN METABOLISM; CONTROLLED STUDY; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; MALE; RAT; STAINING;

EID: 0031053208     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1997.14.15     Document Type: Article

References (42)

1. BARTUS, R.T., BAKER, K.L., HEISER, A.D., et al (1994a). Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J. Cereb. Blood Flow Metab. 14, 537-544.
2. BARTUS, R.T., HAYWARD, N.J., ELLIOTT, P.J., et al (1994b). Calpain inhibitor AK295 protects neurons from focal brain ischemia: Effects of postocclusion intraarterial administration. Stroke 25, 2265-2270.
3. BEDERSON, J.B., PITTS, L.H., GERMANO, S.M., NISHIMURA, M.C., DAVIS, R.L., and BARTKOWSKI, H.M. (1986). Evaluation of 2,3,4-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction on rats. Stroke 17, 1304-1308.
4. BOSE, B., JONES, S.C., LORIG, R., FRIEL, H.T., WEINSTEIN, M., and LITTLE, J.R. (1988). Evolving focal cerebral ischemia in cats: Spatial correlation of nuclear magnetic resonance imaging, cerebral blood flow, tetrazolium staining, and histopathology. Stroke 19, 28-37.
5. CLARK, R.K., LEE, E.V., FISH, C.J., et al (1993). Development of tissue damage, inflammation and resolution following stroke: An immunohistochemical and quantitative planimetric study. Brain Res. Bull. 31, 565-572.
6. COLE, D.J., DRUMMOND, J.C., GHAZAL, E.A., and SHAPIRO, H.M. (1990). A reversible component of cerebral injury as identified by the histochemical stain 2,3,5-triphenyltetrazolium chloride (TTC). Acta Neuropathol. 80, 152-155.
7. COLE, D.J., SCHELL, R.M., DRUMMOND, J.C., PRYZBELSKI, R.J., and MARCANTONIO, S. (1993). Focal cerebral ischemia in rats: Effect of hemodilution with α-α crosslinked hemoglobin on brain injury and edema. Can. J. Neurol. Sci. 20, 30-36.
8. CORTEZ, S.C., MCINTOSH, T.K., and NOBLE, L. (1989). Experimental fluid percussion brain injury: Vascular disruption and neuronal and glial alterations. Brain Res. 482, 271-282.
9. DIETRICH, W.D., ALONSO, O., BUSTO, R., GLOBUS, M.Y., and GINSBERG, M.D. (1994a). Posttraumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat. Acta Neuropathol. 87, 250-258.
10. DIETRICH, W.D., ALONSO, O., and HALLEY, M. (1994b). Early microvascular and neuronal consequences of traumatic brain injury: A light and electron microscopic study in rats. J. Neurotrauma 11, 289-301.
11. ELGER, B., SEEGA, J., and RASCHACK, M. (1994). Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging. Eur. J. Pharmacol. 254, 65-71.
12. FADEN, A.I. (1993). Comparison of single and combined drug treatment strategies in experimental brain trauma. J. Neurotrauma 10, 91-100.
13. HEINEL, L.A., RUBIN, S., ROSENWASSER, R.H., VASTHARE, U.S., and TUMA, R.F. (1994). Leukocyte involvement in cerebral infarct generation after ischemia and reperfusion. Brain Res. Bull. 34, 137-141.
14. HILL, S.J., BARBARESE, E., and MCINTOSH, T.K. (1996). Regional heterogeneity in the response of astrocytes following traumatic brain injury in the adult rat. J. Neuropathol. Exp. Neurol. 55, 1221-1229.
15. HOVDA, D.A., BECKER, D.P., and KATAYAMA, K. (1992). Secondary injury and acidosis. J. Neurotrauma 9, 547-560.
16. ISAYAMA, K., PITTS, L.H., and NISHIMURA, M.C. (1991). Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts. Stroke 28, 1394-1398.
17. KIYOTA, Y., PAHLMARK, K., MEMEZAWA, H., SMITH, M-L., and SIESJÖ, B.K. (1993). Free radicals and brain damage due to transient middle cerebral artery occlusion: The effect of dimethylthiourea. Exp. Brain Res. 95, 388-396.
18. LISZCZAK, T.M., HEDLEY-WHYTE, E.T., ADAMS, J.F., et al (1984). Limitations of tetrazolium salts in delineating infarcted brain. Acta Neuropathol. 65, 150-157.
19. MARINOV, M., WASSMANN, H., and NATSCHEV, S. (1991). Effect of nimodipine in treatment of experimental focal cerebral ischaemia. Neurol. Res. 13, 77-83.
20. MCINTOSH, T.K. (1994). The neurochemical sequelae of traumatic brain injury: Therapeutic implications. Cerebrovasc. Brain Metab. Rev. 6, 109-162.
21. MCINTOSH, T.K., VINK, R., NOBLE, L., YAMAKAMI, I., FERNYAK, S., and FADEN, A.I. (1989). Traumatic brain injury in the rat: Characterization of a lateral fluid percussion model. Neuroscience 28, 233-244.
22. MEMEZAWA, H., MINAMISAWA, H., SMITH, M-L., and SIESJÖ, B.K. (1992). Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp. Brain Res. 89, 67-78.
23. MINEMATSU, K., LI, L., FISHER, M., SOTAK, C.H., DAVIS, M.A., and FIANDACA, M.S. (1992). Diffusion-weighted magnetic resonance imaging: Rapid and quantitative detection of focal brain ischemia. Neurology 42, 235-240.
24. OKIYAMA, K., SMITH, D.H., THOMAS, M.J., and MCINTOSH, T.K. (1992). Evaluation of a novel calcium channel blocker (S)-emopamil on regional cerebral edema and neurobehavioral function after experimental brain injury. J. Neurosurg. 77, 607-615.
25. OKIYAMA, K., ROSENKRANTZ, T.S., SMITH, D.H., GENNARELLI, T.A., and MCINTOSH, T.K. (1994). (S)-Emopamil attenuates regional cerebral blood flow reduction following experimental brain injury. J. Neurotrauma 11, 83-95.
26. PARK, C.K., MENDELOW, A.D., GRAHAM, D.I., MCCULLOCH, J., and TEASDALE, G.M. (1988). Correlation of triphenyltetrazolium chloride perfusion staining with conventional neurohistology in the detection of early brain ischaemia. Neuropath. Appl. Neurobiol. 14, 289-298.
27. PITTS, L., and MCINTOSH, T.K. (1990). Dynamic changes after brain trauma, in: Handbook of Clinical Neurology, Elsevier: NY, pp. 65-100.
28. RANJAN, A., THEODORE, D., HARAN, R.P., and CHANDY, M.J. (1993). Ascorbic acid and focal cerebral ischaemia in a primate model. Acta Neurochir. 123, 87-91.
29. SAEED, D., GOETZMAN, B.W., and GOSPE, S.M. (1993). Brain injury and protective effects of hypothermia using triphenyltetrazolium chloride in neonatal rat. Pediatr. Neurol. 9, 263-267.
30. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., CLAUSSEN, B., and MCINTOSH, T.K. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris Water Maze. J. Neurotrauma 8, 259-269.
31. SMITH, D.H., OKIYAMA, K., THOMAS, M.J., and MCINTOSH, T.K. (1993). Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J. Neurosci. 13, 5383-5392.
32. SMITH, D.H., OKADA, T., MCINTOSH, T.K., and CHANCE, B. (1994). Redox ratio following experimental brain injury. Soc. Neurosci. Abstr. 20, 424.
33. SOARES, H.D., THOMAS, M.J., CLOHERTY, K., and MCINTOSH, T.K. (1992). Development of prolonged focal cerebral edema and regional cation change following experimental brain injury in the rat. J. Neurochem. 58, 1845-1852.
34. SOARES, H.D., HICKS, R.R., SMITH, D.H., and MCINTOSH, T.K. (1995). Inflammatory leukocytic recruitment and diffuse neuronal degeneration are separate pathological processes resulting from traumatic brain injury. J. Neurosci. 15, 8223-8233.
35. TANNO, H., NOCKELS, R.P., PITTS, L.H., and NOBLE, L.J. (1992). Breakdown of the blood brain barrier after fluid percussion injury in the rat. Part I. Distribution and time course of protein extravasation. J. Neurotrauma 9(1), 21-32.
36. TOULMOND, S., SERRANO, A., BENAVIDES, J., and SCATTON, B. (1993). Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window. Brain Res. 620, 32-41.
37. VINK, R. (1994). The measurement of metabolic changes after central nervous system trauma, in: The Neurobiology of Central Nervous System Trauma, A.I. Faden and S.K. Salzman (eds), Oxford University Press: NY, pp. 68-78.
38. VINK, R., HEAD, V.A., ROGERS, P.J., MCINTOSH, T.K., and FADEN, A.I. (1990). Mitochondrial metabolism following traumatic brain injury in rats. J. Neurotrauma 7, 21.
39. VINK, R., GOLDING, E.M., and HEADRICK, J.P. (1994). Bioenergetic analysis of oxidative metabolism following traumatic brain injury in rats. J. Neurotrauma 11, 265-274.
40. YAMAKAMI, I., and MCINTOSH, T.K. (1989). Effects of traumatic brain injury on regional cerebral blood flow in rats as measured with radiolabeled microspheres. J. Cereb. Blood Flow Metab. 9, 117-124.
41. YAMAKAMI, I., and MCINTOSH, T.K. (1991). Alterations in regional cerebral blood flow following brain injury in the rat. J. Cereb. Blood Flow Metab. 11, 655-660.
42. YOSHINO, A., HOVDA, D.A., KAWAMATA, T., KATAYAMA, Y., and BECKER, D.P. (1991). Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: Evidence of hyper and subsequent hypometabolic state. Brain Res. 561, 106-119.