Sustained release formulations of rhVEGF165 produce a durable response in a murine model of peripheral angiogenesis

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 2, 2011, Pages 289-297

  Daugherty, Ann L ^a   Rangell, Linda K ^a   Eckert, Renee ^a   Zavala Solorio, Jose ^a   Peale, Frank ^a   Mrsny, Randall J ^a,b  

^a GENENTECH INC   (United States)

^b University of Bath   (United Kingdom)

Author keywords

Angiogenesis; Peripheral vascular disease; PLGA microspheres; PLGA:NMP gels; Vascular casts; Vascular endothelial growth factor

Indexed keywords

1 METHYL 2 PYRROLIDINONE; MICROSPHERE; PLACEBO; POLYGLACTIN; RECOMBINANT HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A 165; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN ANTIBODY;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL PERMEABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; FREEZE DRYING; GASTROCNEMIUS MUSCLE; GEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; RAT; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SUSTAINED DRUG RELEASE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; RECOMBINANT PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955827702     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.03.011     Document Type: Article

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