Development of poly-(D,L-lactide-coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 13-24

  Cleland, Jeffrey L ^a   Duenas, Eileen T ^a   Park, Ann ^a   Daugherty, Ann ^a   Kahn, Jeanne ^a   Kowalski, Joseph ^a   Cuthbertson, Andrew ^a  

^a GENENTECH INC   (United States)

Author keywords

Angiogenesis; Cornea; Neovascularization; PLG microspheres; Protein stability; Recombinant human vascular endothelial growth factor (rhVEGF); Vitreous

Indexed keywords

HEPARIN; MICROSPHERE; POLYGLACTIN; PROTEIN; SUGAR; TREHALOSE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORNEA; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; LENS IMPLANTATION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA MACULA AGE RELATED DEGENERATION; RETINOPATHY;

ANIMALS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; CORNEA; DRUG CARRIERS; ENDOTHELIAL GROWTH FACTORS; HEPARIN; LACTIC ACID; LYMPHOKINES; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; NEOVASCULARIZATION, PHYSIOLOGIC; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; SOLUBILITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035858370     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00258-9     Document Type: Article

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