A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway

Biochemistry

Volumn 50, Issue 19, 2011, Pages 3859-3861

  Hollenhorst, Marie A ^a   Ntai, Ioanna ^b   Badet, Bernard ^c   Kelleher, Neil L ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC ACTIVITY; BIOSYNTHETIC PATHWAY; DI-PEPTIDES; GLUCOSAMINE-6-PHOSPHATE SYNTHASE; TARGET CELLS;

ANTIBIOTICS; BIOSYNTHESIS; ENZYMES;

GLUCOSAMINE;

ANTIBIOTIC AGENT; DAPDIAMIDE; ENEAMIDE; ENZYME INHIBITOR; EPOXYAMIDE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

ADENYLATION; AMIDATION; AMINATION; ANTIMICROBIAL ACTIVITY; ARTICLE; BIOSYNTHESIS; COVALENT BOND; ENZYME INACTIVATION; ERWINIA AMYLOVORA; ESCHERICHIA COLI; ISOMERIZATION; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

AMIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TOXINS; DIPEPTIDES; EPOXY COMPOUNDS; ERWINIA AMYLOVORA; ESCHERICHIA COLI K12; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); PANTOEA; STEREOISOMERISM;

EID: 79955823487     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2004735     Document Type: Article

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