Comparing hemodynamics, blood gas analyses and proinflammatory cytokines in endotoxemic and severely septic rats

International Immunopharmacology

Volumn 11, Issue 6, 2011, Pages 719-723

  Scheiermann, Patrick ^a,b   Hoegl, Sandra ^b   Hofstetter, Christian ^c   Pfeilschifter, Josef ^a   Zwissler, Bernhard ^b   Mühl, Heiko ^a   Boost, Kim A ^b   Scheller, Bertram ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cecal ligation and incision; Inflammation; Lipopolysaccharide; LPS; Sepsis

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD GAS ANALYSIS; CARDIOPULMONARY HEMODYNAMICS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; HYPOTENSION; IMMUNE DEFICIENCY; MALE; METABOLIC ACIDOSIS; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; SEPSIS; SHAM PROCEDURE;

ACIDOSIS; ANIMALS; BLOOD GAS ANALYSIS; CECUM; CELLS, CULTURED; CYTOKINES; ENDOTOXEMIA; HEMODYNAMICS; HUMANS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79955821704     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.01.020     Document Type: Article

References (30)

1. Vincent JL, Atalan HK. Epidemiology of severe sepsis in the intensive care unit. Br J Hosp Med (Lond) 2008;69:442-3.
2. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
3. Poli-de-Figueiredo LF, Garrido AG, Nakagawa N, Sannomiya P. Experimental models of sepsis and their clinical relevance. Shock 2008;30(Suppl 1):53-9.
4. Boost KA, Flondor M, Hofstetter C, Platacis I, Stegewerth K, Hoegl S, et al. The beta-adrenoceptor antagonist propranolol counteracts anti-inflammatory effects of isoflurane in rat endotoxemia. Acta Anaesthesiol Scand 2007;51:900-8. (Pubitemid 47063014)
5. Boost KA, Hoegl S, Hofstetter C, Flondor M, Stegewerth K, Platacis I, et al. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive Care Med 2007;33:863-71.
6. Rittirsch D, Hoesel LM, Ward PA. The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol 2007;81:137-43. (Pubitemid 46021262)
7. Nahra R, Dellinger RP. Targeting the lipopolysaccharides: still a matter of debate? Curr Opin Anaesthesiol 2008;21:98-104.
8. Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 1980;29:189-201. (Pubitemid 10039498)
9. Kox WJ, Volk T, Kox SN, Volk HD. Immunomodulatory therapies in sepsis. Intensive Care Med 2000;26(Suppl 1):S124-8.
10. Hotchkiss RS, Opal S. Immunotherapy for sepsis - a new approach against an ancient foe. N Engl J Med 2010;363:87-89.
11. Scheiermann P, Hoegl S, Revermann M, Ahluwalia D, Zander J, Boost KA, et al. Cecal ligation and incision: an acute onset model of severe sepsis in rats. J Surg Res 2009;151:132-7.
12. Scheiermann P, Ahluwalia D, Hoegl S, Dolfen A, Revermann M, Zwissler B, et al. Effects of intravenous and inhaled levosimendan in severe rodent sepsis. Intensive Care Med 2009;35:1412-9.
13. Ziesche E, Scheiermann P, Bachmann M, Sadik CD, Hofstetter C, Zwissler B, et al. Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo. Clin Exp Immunol 2009;157:370-6.
14. Scheiermann P, Ott J, Hoegl S, Hecker M, Hofstetter C, Seeger W, Zwissler B, et al. Effects of short-term infusion of lipid emulsions on pro-inflammatory cytokines and lymphocyte apoptosis in septic and non-septic rats. Br J Nutr. in press.
15. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-6. (Pubitemid 36444440)
16. Hofstetter C, Boost KA, Flondor M, Basagan-Mogol E, Betz C, Homann M, et al. Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats. Acta Anaesthesiol Scand 2007;51:893-9. (Pubitemid 47063005)
17. Singh S, Evans TW. Organ dysfunction during sepsis. Intensive Care Med 2006;32: 349-60. (Pubitemid 43289643)
18. Thiemermann C. Nitric oxide and septic shock. Gen Pharmacol 1997;29:159-66. (Pubitemid 27312364)
19. Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003;31:2332-8. (Pubitemid 37100836)
20. Reinhart K, Wiegand-Lohnert C, Grimminger F, Kaul M, Withington S, Treacher D, et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195 F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996;24:733-42.
21. Fisher Jr CJ, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, et al. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996;334:1697-702. (Pubitemid 26193621)
22. Opal SM, Fisher Jr CJ, Dhainaut JF, Vincent JL, Brase R, Lowry SF, et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 1997;25:1115-24. (Pubitemid 27310249)
23. Song M, Kellum JA. Interleukin-6. Crit Care Med 2005;33:S463-5.
24. Flondor M, Listle H, Kemming GI, Zwissler B, Hofstetter C. Effect of inhaled and intravenous lidocaine on inflammatory reaction in endotoxaemic rats. Eur J Anaesthesiol 2010;27:53-60.
25. O'Neill LA, Dunne A, Edjeback M, Gray P, Jefferies C, Wietek C. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J Endotoxin Res 2003;9:55-9. (Pubitemid 36322486)
26. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003;348:138-50. (Pubitemid 36056721)
27. Wang P, Ba ZF, Chaudry IH. Mechanism of hepatocellular dysfunction during early sepsis. Key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6. Arch Surg 1997;132:364-70.
28. Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL. Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun 1996;64:4733-8. (Pubitemid 26357085)
29. Niu L, Qiao W, Li G, Li Q, Huang Q, Gong J, et al. Different alterations in rat intestinal glutamine transport during the progression of clp- and lps-induced sepsis. J Surg Res. in press.
30. Debets JM, Kampmeijer R, van der Linden MP, Buurman WA, van der Linden CJ. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med 1989;17:489-94. (Pubitemid 19146077)