A proteomic investigation of B lymphocytes in an autistic family: A pilot study of exposure to Natural Rubber Latex (NRL) may lead to autism

Journal of Molecular Neuroscience

Volumn 43, Issue 3, 2011, Pages 443-452

  Shen, Chen ^a,b,f   Zhao, Xin Liang ^a,b   Ju, Weina ^c   Zou, Xiao Bing ^d   Huo, Li Rong ^a,e   Yan, Wu ^a,b   Zou, Jun Hua ^a,b   Yan, Guo Di ^a,b   Jenkins, Edmund C ^c   Brown, W Ted ^c   Zhong, Nanbert ^a,b,c  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

^e SHANXI MEDICAL UNIVERSITY   (China)

^f CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Autism; IKK ; Neurodevelopmental disorder; NFkB; NRL; Tyk2

Indexed keywords

I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4G; LATEX; NATURAL RUBBER LATEX; PROTEIN; PROTEIN ANTIBODY; PROTEIN KINASE C IOTA; PROTEIN KINASE TYK2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUTISM; B LYMPHOCYTE; CELL CYCLE; CHILD; CHINESE; CLINICAL TRIAL; DOWN REGULATION; HEVEA BRASILIENSIS; HUMAN; IMMUNITY; PILOT STUDY; PROTEIN EXPRESSION; PROTEOMICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ASIAN CONTINENTAL ANCESTRY GROUP; AUTISTIC DISORDER; B-LYMPHOCYTES; CELL CYCLE; CELL LINE; CHILD; CHILD, PRESCHOOL; FEMALE; HEVEA; HUMANS; LATEX; LATEX HYPERSENSITIVITY; MALE; PEDIGREE; PILOT PROJECTS; PROTEIN ARRAY ANALYSIS; PROTEOME; RUBBER;

HEVEA BRASILIENSIS;

EID: 79955801652     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9463-5     Document Type: Article

References (50)

1. Allen-Brady K, Miller J, Matsunami N, Stevens J, Block H, Farley M, Krasny L, Pingree C, Lainhart J, Leppert M, McMahon WM, Coon H (2009) A high-density SNP genome-wide linkage scan in a large autism extended pedigree. Mol Psychiatry 14:590-600
2. Ashwood P, Van de Water J (2004) Is autism an autoimmune disease? Autoimmun Rev 3:557-562
3. Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ (2007) Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol 8:522-531 (Pubitemid 46605920)
4. Atladóttir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW, Parner ET (2009) Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 124:687-694
5. Bailey A, Phillips W, Rutter M (1996) Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatry 37:89-126 (Pubitemid 26090588)
6. Bakkaloglu B, Anlar B, Anlar FY, Oktem F, Pehlivantürk B, Unal F, Ozbesler C, Gökler B (2008) Atopic features in early childhood autism. Eur J Paediatr Neurol 12(6):476-479
7. Barré B, Perkins ND (2007) A cell cycle regulatory network controlling NF-kappaB subunit activity and function. EMBO J 26:4841-4855 (Pubitemid 350191299)
8. Boris M, Kaiser CC, Goldblatt A, Elice MW, Edelson SM, Adams JB, Feinstein DL (2007) Effect of pioglitazone treatment on behavioral symptoms in autistic children. J Euroinflammation 4:3
9. Careaga M, Van de Water J, Ashwood P (2010) Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 7:283-292
10. Chih B, Afridi SK, Clark L, Scheiffele P (2004) Disorder-associated mutations lead to functional inactivation of neuroligins. Hum Mol Genet 13:1471-1477 (Pubitemid 39023055)
11. Cohly HH, Panja A (2005) Immunological findings in autism. Int Rev Neurobiol 71:317-341 (Pubitemid 43580939)
12. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN (1999) Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 14:388-394 (Pubitemid 29321099)
13. Dochniak MJ (2007) Autism spectrum disorders-exogenous protein insult. Med Hypotheses 69:545-549
14. Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood P (2009) Increased IgG4 levels in children with autism disorder. Brain Behav Immun 23:389-395
15. Fields AP, Regala RP (2007) Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. Pharmacol Res 55:487-497 (Pubitemid 46962307)
16. Firmbach-Kraft I, Byers M, Shows T, Dalla-Favera R, Krolewski JJ (1990) Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 5:1329-1336
17. Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18:2195-2224
18. Ishikawa H, Carrasco D, Claudio E, Ryseck RP, Bravo R (1997) Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2. J Exp Med 186:999-1014 (Pubitemid 27441145)
19. Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N et al (2001) I kappa B kinase alpha is essential for mature B cell development and function. J Exp Med 193:417-426 (Pubitemid 32524473)
20. Libbey JE, Fujinami RS (2010) Role for antibodies in altering behavior and movement. Autism Res 3:147-152. doi:10.1002/aur.144
21. Lindelöf B, Granath F, Tengvall-Linder M, Lindelöf H, Ekbom A (2009) Allergy and autoimmune disease: a registry-based study. Clin Exp Allergy 9:110-115
22. Magalhães ES, Pinto-Mariz F, Bastos-Pinto S, Pontes AT, Prado EA, de Azevedo LC (2009) Immune allergic response in Asperger syndrome. J Neuroimmunol 216:108-112
23. McAllister AK, van de Water J (2009) Breaking boundaries in neuralimmune interactions. Neuron 64:9-12
24. McCauley JL, Li C, Jiang L, Olson LM, Crockett G, Gainer K, Folstein SE, Haines JL, Sutcliffe JS (2005) Genome-wide and ordered-subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med Genet 6:1
25. Minegishi Y, Karasuyama H (2007) Hyperimmunoglobulin E syndrome and tyrosine kinase two deficiency. Curr Opin Allergy Clin Immunol 7:506-509 (Pubitemid 350076445)
26. Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H (2006) Human tyrosine kinase two deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25:745-755 (Pubitemid 46131400)
27. Mobyuddin A, Ayub Q, Sidiqi S, Carvalho-Silva DR, Mazhar K, Rehman S, Firasat S, Dar A, Tyler-Smith C, Mehdi SQ (2004) Genetic instability in EBV transformed lymphoblastoid cell line. Biochem Biophys Acta 1670:2356-2360
28. Moessner R, Marshall CR, Sutcliffe JS, Skaug J, Pinto D, Vincent J, Zwaigenbaum L, Fernandez B, Roberts W, Szatmari P, Scherer SW (2007) Contribution of SHANK3 mutations to autism spectrum disorder. Am J Hum Genet 81:1289-1297 (Pubitemid 350211458)
29. Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning-Courtney P, Altaye M, Wills-Karp M (2006) Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol 172:198-205
30. Mouridsen SE, Rich B, Isager T, Nedergaard NJ (2007) Autoimmune diseases in parents of children with infantile autism: a case-control study. Dev Med Child Neurol 49:429-432 (Pubitemid 46845376)
31. Neitzel H (1986) A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum Genet 73:320-326
32. Okazaki Y, Suzuki A, Sawada T, Ohtake-Yamanaka M, Inoue T, Hasebe T, Yamada R, Yamamoto K (2006) Identification of citrullinated eukaryotic translation initiation factor 4 G1 as novel autoantigen in rheumatoid arthritis. Biochem Biophys Res Commun 341:94-100 (Pubitemid 43117390)
33. Parker S, Todd J, Schwartz B, Pickering L (2005) Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics 115:200 (Pubitemid 43046316)
34. Peng Y, Power MR, Li B, Lin TJ (2005) Inhibition of IKK downregulates antigen+IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. J Leukoc Biol 77:975-983 (Pubitemid 40770850)
35. Prévôt D, Darlix JL, Ohlmann T (2003) Conducting the initiation of protein synthesis: the role of eIF4G. Biol Cell 95:141-156
36. Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP (2005) Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem 280:31109-31115 (Pubitemid 41291846)
37. Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (1997) Identification and characterization of an Ikappa B kinase. Cell 90:373-383
38. Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, Kalaydjieva L, McCague P, Dimiceli S, Pitts T, Nguyen L, Yang J et al (1999) A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet 65:493-507 (Pubitemid 30463007)
39. Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, Schmid RM (2006) IKKαlpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. EMBO J 25:3801-3812 (Pubitemid 44300266)
40. Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I (2003) Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol 170:1077-1083 (Pubitemid 36070564)
41. Singer HS, Morris CM, Williams PN, Yoon DY, Hong JJ, Zimmerman AW (2006) Antibrain antibodies in children with autism and their unaffected siblings. J Neuroimmunol 178:149-155 (Pubitemid 44314179)
42. Stern L, Francoeur MJ, Primeau MN, Sommerville W, Fombonne E, Mazer BD (2005) Immune function in autistic children. Ann Allergy Asthma Immunol 95:558-565 (Pubitemid 43010483)
43. Talebizadeh Z, Butler MG, Theodoro MF (2008) Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res 1:240-250
44. Tordjman S, Anderson GM, Botbol M, Brailly-Tabard S, Perez-Diaz F, Graignic R, Carlier M, Schmit G, Rolland A-C, Bonnot O, Trabado S, Roubertoux P, Bronsard G (2009) Pain reactivity and plasma β-endorphin in children and adolescents with autistic disorder. PLoS ONE 4:5289. doi:10.1371/journal.pone. 0005289
45. Valenta R, Mittermann I, Werfel T, Garn H, Renz H (2009) Linking allergy to autoimmune disease. Trends Immunol 30:109-116
46. Vercelli D, Jabara HH, Cunningham-Rundles C, Abrams JS, Lewis DB, Meyer J, Schneider LC, Leung DY, Geha RS (1990) Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome. J Clin Invest 85:1666-1671
47. Win HY, Acevedo-Duncan M (2008) Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival. Cancer Lett 270:302-311
48. Ylisaukko-oja T, Alarcón M, Cantor RM, Auranen M, Vanhala R, Kempas E, von Wendt L, Järvelä I, Geschwind DH, Peltonen L (2006) Search for autism loci by combined analysis of autism genetic resource exchange and finnish families. Ann Neurol 59:145-155 (Pubitemid 43042881)
49. Zhang L, Huang J, Yang N, Liang S, Barchetti A, Giannakakis A, Cadungog MG, O'Brien-Jenkins A, Massobrio M, Roby KF, Katsaros D, Gimotty P, Butzow R, Weber BL, Coukos G (2006) Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma. Cancer Res 66:4627-4635
50. Ziv Y, Schwartz M (2008) Immune-based regulation of adult neurogenesis: implications for learning and memory. Brain Behav Immun 22:167-176 (Pubitemid 350299808)