Downregulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration

Islets

Volumn 3, Issue 3, 2011, Pages 80-88

  Reers, Christina ^a   Hauge Evans, Astrid C ^a   Morgan, Noel G ^b   Willcox, Abby ^b   Persaud, Shanta J ^a   Jones, Peter M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

cell lines; Differentiation; Growth arrest; Mitomycin c; Proliferation; Pseudoislets

Indexed keywords

INSULIN; MITOMYCIN C; DOXYCYCLINE; MITOMYCIN; NUCLEIC ACID SYNTHESIS INHIBITOR;

ARTICLE; CELL ASSAY; CELL LEVEL; CELL LINE; CELL LOSS; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; MESENCHYMAL STEM CELL; MONOLAYER CULTURE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PROTEIN CONTENT; PSEUDOISLET; ANIMAL; CELL GROWTH; CYTOCHEMISTRY; CYTOLOGY; DRUG EFFECT; MOUSE; PHYSIOLOGY; SECRETION;

ANIMALS; CELL GROWTH PROCESSES; CELL LINE, TRANSFORMED; DOWN-REGULATION; DOXYCYCLINE; HISTOCYTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MICE; MITOMYCIN; NUCLEIC ACID SYNTHESIS INHIBITORS;

EID: 79955798808     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.3.3.15428     Document Type: Article

References (28)

1. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995; 44:249-56.
2. Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005; 54:2557-67. (Pubitemid 41233576)
3. Persaud SJ. Advances in molecular and cell biology. Bittar EE, Howell SL, Eds. JAI press Inc., London. Ref Type: Serial (Book, Monograph) 1999; 21-46.
4. Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S. Epithelial-mesenchymal transition in cells expanded vitro from lineage-traced adult human pancreatic beta cells. PLoS One 2009; 4:6417.
5. + cells derived from human islets. Diabetes 1999; 48:1013-9.
6. Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y. Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes 2007; 56:1299-304. (Pubitemid 46715610)
7. Fleischer N, et al. Functional analysis of a conditionally transformed pancreatic beta-cell line. Diabetes 1998; 47:1419-25. (Pubitemid 28396945)
8. Bosco D, Orci L, Meda P. Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells. Exp Cell Res 1989; 184:72-80. (Pubitemid 19233388)
9. Halban PA, Powers SL, George KL, Bonner-Weir S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 1987; 36:783-90. (Pubitemid 17146577)
10. Hopcroft DW, Mason DR, Scott RS. Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion. Endocrinology 1985; 117:2073-80. (Pubitemid 16194263)
11. Pipeleers DG, et al. Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology 1985; 117:824-33. (Pubitemid 15019999)
12. 2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 1999; 48:1402-8.
13. Luther MJ, et al. MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Commun 2006; 343:99-104.
14. Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chem Biol 1995; 2:575-9.
15. Tomasz M, Palom Y. The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity. Pharmacol Ther 1997; 76:73-8.
16. Huang YC, Wang TW, Sun JS, Lin FH. Investigation of mitomycin-C-treated fibroblasts in 3-D collagen gel and conditioned medium for keratinocyte proliferation. Artif Organs 2006; 30:150-9.
17. Blacker KL, Williams ML, Goldyne M. Mitomycin C-treated 3T3 fibroblasts used as feeder layers for human keratinocyte culture retain the capacity to generate eicosanoids. J Invest Dermatol 1987; 89:536-9.
18. Milo-Landesman D, et al. Correction of hyperglycemia in diabetic mice transplanted with reversibly immortalized pancreatic beta cells controlled by the tet-on regulatory system. Cell Transplant 2001; 10:645-50. (Pubitemid 34241692)
19. Simpson NE, et al. Effects of growth regulation on conditionally- transformed alginate-entrapped insulin secreting cell lines in vitro. Biomaterials 2005; 26:4633-41. (Pubitemid 40269280)
20. O'Driscoll L, et al. Phenotypic and global gene expression profile changes between low passage and high passage MIN-6 cells. J Endocrinol 2006; 191:665-76. (Pubitemid 46210291)
21. Beattie GM, Cirulli V, Lopez AD, Hayek A. Ex vivo expansion of human pancreatic endocrine cells. J Clin Endocrinol Metab 1997; 82:1852-6. (Pubitemid 127495199)
22. Kayali AG, et al. Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing beta-cells. Diabetes 2007; 56:703-8. (Pubitemid 46348470)
23. Miyazaki J, et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 1990; 127:126-32. (Pubitemid 20228111)
24. Ishihara H, et al. Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 1993; 36:1139-45. (Pubitemid 23314564)
25. Cozar-Castellano I, et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 2006; 27:356-70. (Pubitemid 43848303)
26. Heit JJ, Karnik SK, Kim SK. Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 2006; 22:311-38.
27. Luther MJ, et al. Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures. Am J Physiol Endocrinol. Metab 2005; 288:502-9.
28. Hauge-Evans AC, et al. Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets. Mol Cell Endocrinol 2002; 191:167-76. (Pubitemid 34626622)