Changes in retinol-binding protein concentrations and thyroid homeostasis with nonoccupational exposure to DDT

Environmental Health Perspectives

Volumn 119, Issue 5, 2011, Pages 647-651

  Delport, Rhena ^a   Bornman, Riana ^a   MacIntyre, Una E ^b   Oosthuizen, Nicholette M ^a   Becker, Piet J ^c   Aneck Hahn, Natalie H ^a   de Jager, Christiaan ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

DDT; Endocrine disruptors; Retinol binding protein; Thyroid homeostasis

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CHLORPHENOTANE; GAMMA GLUTAMYLTRANSFERASE; LIOTHYRONINE; PREALBUMIN; RETINOL; RETINOL BINDING PROTEIN; THYROTROPIN; THYROXINE; ZINC;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLERGY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOACCUMULATION; BODY MASS; CALORIC INTAKE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; EPIDIDYMITIS; FEVER; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIOTHYRONINE BLOOD LEVEL; LIVER FUNCTION; LONG TERM EXPOSURE; MALARIA; MALE; NUTRITIONAL STATUS; ORCHITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INTAKE; SEXUALLY TRANSMITTED DISEASE; SINUSITIS; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TUBERCULOSIS; URINARY TRACT INFECTION; VITAMIN INTAKE; VITAMIN METABOLISM;

ADOLESCENT; ADULT; DDT; HUMANS; MALE; RETINOL-BINDING PROTEINS; THYROID GLAND; THYROXINE; TRIIODOTHYRONINE; YOUNG ADULT;

EID: 79955791732     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002616     Document Type: Article

References (31)

1. Ahlborg UG, Lipworth L, Titus-Ernstoff L, Hsieh CC, Hanberg A, Baron J, et al. 1995. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit Rev Toxicol 25:463-531.
2. Aneck-Hahn NH, Schulenburg GW, Bornman MS, Farias P, de Jager C. 2007. Impaired semen quality associated with environmental DDT exposure in young men living in a malaria area in the Limpopo Province, South Africa. J Androl 28(3):423-434.
3. Boas M, Main KM, Feldt-Rasmussen U. 2009. Environmental chemicals and thyroid function: an update. Curr Opin Endocrinol Diabetes Obes 16(5):385-391.
4. Bornman R, de Jager C, Worku Z, Farias P, Reif S. 2010. DDT and urogenital malformations in newborn boys in a malarial area. BJU Int 106(3):405-411.
5. Boron B, Hupert J, Barch DH, Fox CC, Friedman H, Layden TJ, et al. 1988. Effect of zinc deficiency on hepatic enzymes regulating vitamin A status. J Nutr 118:995-1001.
6. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ, Klasson-Wehler E, et al. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animals and human health. Toxicol Ind Health 14:59-84.
7. Colborn T, vom Saal FS, Soto AM. 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378-384.
8. Danzo BJ. 1997. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 105:294-301.
9. Dati F, Schumann G, Thomas L, Aguzzi F, Baudner S, Bienvenu J, et al. 1996. Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC/BCR/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists. Eur J Clin Chem Clin Biochem 34:517-520.
10. Food and Nutrition Board, Institute of Medicine. 2000. Dietary Reference Intakes. Application in Dietary Assessment. Washington, DC:National Academy Press.
11. Gamble MV, Ramakrishnan R, Palafox NA, Briand K, Berglund L, Blaner WS. 2001. Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands. Am J Clin Nutr 73(3):594-601.
12. Hauser R, Chen ZY, Pothier L, Ryan L, Altshul L. 2003. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p-DDE. Environ Health Perspect 111:1505-1511.
13. Li J, Ma M, Wang Z. 2008. A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene expression. Toxicol Lett 176:198-206.
14. MacIntyre UE, Bornman M. 2004. Using a validation study to improve a food frequency questionnaire [Abstract]. S Afr J Clin Nutr 17(suppl):S16.
15. MacIntyre UE, Kruger HS, Venter CS, Vorster HH. 2002. Dietary intakes of an African population in different stages of transition in the North West Province, South Africa: the THUSA study. Nutr Res 22:239-256.
16. Medical Research Council of South Africa. 2010. FoodFinder. Available: http://foodfinder.mrc.ac.za/ [accessed 24 March 2011].
17. Meeker JD, Altshul L, Hauser R. 2007. Serum PCBs, p,p ́-DDE and HCB predict thyroid hormone levels in men. Environ Res 104(2):296-304.
18. Nagayama J, Kohno H, Kunisue T, Kataoka K, Shimomura H, Tanabe S, et al. 2007. Concentrations of organochlorine pollutants in mothers who gave birth to neonates with congenital hypothyroidism. Chemosphere 68(5):972-976.
19. Noy N. 2000. Retinoid-binding proteins: mediators of retinoid action. Biochem J 348:481-495.
20. Quadro L, Hamberger L, Colantuoni V, Gottesman ME, Blaner WS. 2003. Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models. Mol Aspects Med 24:421-430.
21. Rolland RM. 2000. A review of chemically-induced alterations in thyroid and vitamin A status from field studies of wildlife and fish. J Wildl Dis 36(4):615-635.
22. Rosales FJ, Chau KK, Haskell MH, Shankar AH. 2002. Determination of a cut-off value for the molar ratio of retinol-binding protein to transthyretin (RBP:TTR) in Bangladeshi patients with low hepatic vitamin A stores. J Nutr 132:3687-3692.
23. Rosales FJ, Ross AC. 1998. A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation: studies in rats and a posterior analysis of vitamin A-supplemented children with measles. J Nutr 128(10):1681-1687.
24. Rylander L, Nilsson-Ehle P, Hagmar L. 2006a. A simplified precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids. Chemosphere 62(3):333-336.
25. Rylander L, Wallin E, Jönssson BA, Stridsberg M, Erfurth EM, Hagmar L. 2006b. Associations between CB-153 and p,p-DDE and hormone levels in serum in middle-aged and elderly men. Chemosphere 65(3):375-381.
26. Smith AG. 1991. Chlorinated hydrocarbon insecticides. In: Handbook of Pesticides Toxicology, Vol 2, Classes of Pesticides (Hayes WJ, Laws ER, eds). New York: Academic Press, 731-915.
27. Solomons NW, Russell RM. 1980. The interaction of vitamin A and zinc: implications for human nutrition. Am J Clin Nutr 33(9):2031-2040.
28. Tanumihardjo SA. 2004. Assessing vitamin A status: past, present and future. J Nutr 134:290S-293S.
29. United Nations. Environment Programme. 2004. Proceedings: UNEP/WHO Sub-Regional Workshop on the Reduction/Elimination and Management of Pesticides in the Context of the Stockholm Convention and Related Activities of WHO, 6-12 May 2004, Bangkok, Thailand. Draft. Available: http://www.chem.unep.ch/Publications/pdf/ProcPestBangkokMay2004.pdf [accessed 25 March 2011].
30. Urbatzka R, Bottero S, Mandich A, Lutz I, Kloas W. 2007. Endocrine disrupters with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: I. Effects on sex steroid levels and biomarker expression. Comp Biochem Physiol C Toxicol Pharmacol 144(4):310-318.
31. Vorster HH, Venter CS, Menssink E, van Staden DA, Labadarios D, Strydom AJC, et al. 1994. Adequate nutritional status despite restricted dietary variety in adult rural Vendas. S Afr J Clin Nutr 7:3-16.