Development and validation of UPLC tandem mass spectrometry assay for separation of a phase II metabolite of ramipril using actual study samples and its application to a bioequivalence study

Biomedical Chromatography

Volumn 25, Issue 6, 2011, Pages 664-673

  Pudage, Ashutosh ^a,b   Kamat, Sudhir ^a  

^a RAMNARAIN RUIA COLLEGE   (India)

^b Accutest Research Laboratories I Pvt Ltd   (India)

Author keywords

Multiple reaction monitoring; Ramipril; Ramiprilat; UPLC MS MS

Indexed keywords

EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION; PLASMA (HUMAN);

ANALYTES; MULTIPLE REACTION MONITORING; PHASE II; RAMIPRIL; RAMIPRILAT; SAMPLE APPLICATIONS; STUDY SAMPLES; TANDEM MASS SPECTROMETRY; TANDEM-MASS SPECTROMETRY; UPLC-MS/MS;

METABOLITES;

DRUG METABOLITE; GLUCURONIDE; RAMIPRIL; RAMIPRILAT;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG HALF LIFE; EXTRACTION; HUMAN; HUMAN EXPERIMENT; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 79955783902     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1500     Document Type: Article

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