Effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury;Travmatik spinal kord yaralanmasi olan siçanlarda paranteral balik yaǧi emülsiyonu ile yapilan beslenme desteǧinin omuriliǧin i̇yileşmesi üzerine etkileri

Turkish Neurosurgery

Volumn 21, Issue 2, 2011, Pages 197-202

  Tural Emon, Selin ^a   Gercek Irban, Arzu ^b   Uyar Bozkurt, Suheyla ^c   Akakin, Dilek ^c   Konya, Deniz ^c   Ozgen, Serdar ^b  

^a Academic Hospital   (Turkey)

^b ACIBADEM UNIVERSITY   (Turkey)

^c MARMARA UNIVERSITY   (Turkey)

Author keywords

Neuron recovery; Nutrition; Omega 3 fatty acids; Omega 6 fatty acids; Spinal cord injury

Indexed keywords

EID: 79955774802     PISSN: 10195149     EISSN: None     Source Type: Journal    
DOI: 10.5137/1019-5149.JTN.3523-10.2     Document Type: Article

References (20)

1. Allen AR: Remarks on the histopathological changes in the spinal cord due to impact. An experimental study. J Nerv Ment Dis 4:141-147, 1914.
2. Basso DM, Beattie MS, Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256, 1996.
3. Bethea JR: Spinal cord injury-induced inflammation: A dualedged sword. Prog Brain Res 128:33-42, 2000.
4. Brockington A, Lewis C, Wharton S, Shaw PJ: Vascular endothelial growth factor and the nervous system. Neuropathol Appl Neurobiol 30:427-446, 2004.
5. Calder PC: Long-chain n-3 fatty acids and inflammation: Potential application in surgical and trauma patients. Braz J Med Biol Res 36:433-446, 2003.
6. Dyall SC, Michael-Titus AT: Neurological benefits of omega-3 fatty acids. Neuromolecular Med 10:219-235, 2008.
7. Fumagalli F, Madaschi L, Brenna P, Caffino L, Marfia G, Di Giulio AM, Racagni G, Gorio A: Single exposure to erythropoietin modulates Nerve Growth Factor expression in the spinal cord following traumatic injury: Comparison with methylprednisolone. Eur J Pharmacol 578:19-27, 2008.
8. Gercek A, Yildirim O, Konya D, Bozkurt S, Ozgen S, Kilic T, Sav A, Pamir N: Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone. J Parent Ent Nutr 31:161-166, 2007.
9. Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, Priestley JV, Michael-Titus AT: A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 130:3004-3019, 2007.
10. Ikemoto A, Kobayashi T, Watanabe S, Okuyama H: Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. Neurochem. Res 22:671-678, 1997.
11. King VR, Huang WL, Dyall SC, Curran OE, Priestley JV, Michael-Titus AT: Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 26:4672-4680, 2006.
12. Koliatsos VE, Crawford TO, Price DL: Axotomy induces nerve growth factor receptor immunoreactivity in spinal motor neurons. Brain Res 549: 297-304, 1991.
13. Konya D, Gercek A, Akakin A, Akakin D, Tural S, Cetinel S, Ozgen S, Pamir MN: The effects of inflammatory response associated with traumatic spinal cord injury in cutaneous wound healing and on expression of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor (PDGF)-A at the wound site in rats. Growth Factors 26:74-79, 2008.
14. Li XL, Zhang W, Zhou X, Wang XY, Zhang HT, Qin DX, Zhang H, Li Q, Li M, Wang TH: Temporal changes in the expression of some neurotrophins in spinal cord transected adult rats. Neuropeptides 41:135-143, 2007.
15. Michael-Titus AT: Omega-3 fatty acids and neurological injury. Prostaglandins Leukot Essent Fatty Acids 77:295-300, 2007.
16. Murakami Y, Furukawa S, Nitta A, Furukawa Y: Accumulation of nerve growth factor protein at both rostral and caudal stumps in the transected rat spinal cord. J Neurol Sci 198:63-69, 2002.
17. Patel CB, Cohen DM, Ahobila-Vajjula P, Sundberg LM, Chacko T, Narayana PA: Effect of VEGF treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: Dynamic contrast-enhanced magnetic resonance imaging. J Neurotrauma 7:1005-1016, 2009.
18. Robson LG, Dyall S, Sidloff D, Michael-Titus AT: Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging 31:678-687, 2010.
19. Rosenstein JM, Krum JM: New roles for VEGF in nervous tissue-beyond blood vessels. Exp Neurol 187:246-253, 2004.
20. Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, Olson L: Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951-960, 2003.