Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway

Biochemical and Biophysical Research Communications

Volumn 408, Issue 3, 2011, Pages 363-368

  Xu, Jianmin ^a   Walsh, Stephanie B ^a   Verney, Zoe M ^a   Kopelovich, Levy ^b   Elmets, Craig A ^a   Athar, Mohammad ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cyclosporine A; Immune suppression; Nonmelanoma skin cancer; Nuclear factor kappa B; TAK1 signaling

Indexed keywords

BINDING PROTEIN; CYCLOSPORIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; TAK BINDING PROTEIN 1; TAK BINDING PROTEIN 2; TUMOR GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; MITOGENESIS; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOSPORINE; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MAP KINASE KINASE KINASES; MICE; MICE, NUDE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79955773918     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.039     Document Type: Article

References (21)

1. Euvrard S., Kanitakis J., Claudy A. Skin cancers after organ transplantation. N. Engl. J. Med. 2003, 348:1681-1691.
2. Berg D., Otley C.C. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J. Am. Acad. Dermatol. 2002, 47:1-17.
3. Martinez O.M., de Gruijl F.R. Molecular and immunologic mechanisms of cancer pathogenesis in solid organ transplant recipients. Am. J. Transplant. 2008, 8:2205-2211.
4. Kronke M., Leonard W.J., Depper J.M., Arya S.K., Wong-Staal F., Gallo R.C., Waldmann T.A., Greene W.C. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. USA 1984, 81:5214-5218.
5. Griffiths E.J., Halestrap A.P. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. Biochem. J. 1991, 274(2):611-614.
6. Tang X., Zhu Y., Han L., Kim A.L., Kopelovich L., Bickers D.R., Athar M. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J. Clin. Invest. 2007, 117:3753-3764.
7. S.B. Walsh, J. Xu, H. Xu, A.R. Kurundkar, A. Maheshwari, W.E. Grizzle, C.C. Huang, L. Kopelovich, C.A. Elmets, M. Athar, Cyclosporine A mediartes Pathogenesis of Aggressive Cutaneous Squamous Cell Cancer by Augmenting Epithelial-Mesenchymal Transition through p38 and Akt Signaling Pathways. Molecular Carcinogenesis (in press).
8. Sakurai H., Miyoshi H., Toriumi W., Sugita T. Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation. J. Biol. Chem. 1999, 274:10641-10648.
9. Sakurai H., Nishi A., Sato N., Mizukami J., Miyoshi H., Sugita T. TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase that stimulates AP-1 and NF-kappaB signaling pathways. Biochem. Biophys. Res. Commun. 2002, 297:1277-1281.
10. Neil J.R., Schiemann W.P. Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res. 2008, 68:1462-1470.
11. Racanelli A.C., Rothbart S.B., Heyer C.L., Moran R.G. Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer Res. 2009, 69:5467-5474.
12. O'Donovan P., Perrett C.M., Zhang X., Montaner B., Xu Y.Z., Harwood C.A., McGregor J.M., Walker S.L., Hanaoka F., Karran P. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005, 309:1871-1874.
13. Hojo M., Morimoto T., Maluccio M., Asano T., Morimoto K., Lagman M., Shimbo T., Suthanthiran M. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 1999, 397:530-534.
14. Harradine K.A., Ridd K., Saunier E.F., Clermont F.F., Perez-Losada J., Moore D.H., Epstein E.H., Bastian B.C., Akhurst R.J. Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients. Clin. Cancer Res. 2009, 15:5101-5107.
15. Liu Q., Busby J.C., Molkentin J.D. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat. Cell Biol. 2009, 11:154-161.
16. Hong S., Lim S., Li A.G., Lee C., Lee Y.S., Lee E.K., Park S.H., Wang X.J., Kim S.J. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat. Immunol. 2007, 8:504-513.
17. Asai T., Nakatani T., Tamada S., Kuwabara N., Yamanaka S., Tashiro K., Nakao T., Komiya T., Okamura M., Kim S., Iwao H., Miura K. Activation of transcription factors AP-1 and NF-kappaB in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation. Transplantation 2003, 75:1040-1044.
18. Corsini E., Viviani B., Marinovich M., Galli C.L. Cyclosporin A exacerbates skin irritation induced by tributyltin by increasing nuclear factor kappa B activation. J. Invest. Dermatol. 2001, 117:1627-1634.
19. Gingery A., Bradley E.W., Pederson L., Ruan M., Horwood N.J., Oursler M.J. TGF-beta coordinately activates TAK1/MEK/AKT/NFκB and SMAD pathways to promote osteoclast survival. Exp. Cell Res. 2008, 314:2725-2738.
20. M. Athar, S.B. Walsh, M.D. Kopelovich, C.A. Elmets, Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. Arch. Biochem. Biophys. (in press) Epub ahead of print.
21. Akool el S., Doller A., Babelova A., Tsalastra W., Moreth K., Schaefer L., Pfeilschifter J., Eberhardt W. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J. Immunol. 2008, 181:2831-2845.