Organometallic iron(iii)-salophene exerts cytotoxic properties in neuroblastoma cells via mapk activation and ros generation

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Kim, Kyu Kwang ^a   Singh, Rakesh K ^a   Strongin, Robert M ^b   Moore, Richard G ^a   Brard, Laurent ^c   Lange, Thilo S ^a,d  

^a BROWN UNIVERSITY   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CUPRIC ION; FERRIC ION SALOPHENE COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; DNA; FERRIC ION; IRON(III) SALOPHENE; IRON(III)-SALOPHENE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SCREENING; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL STRESS; CELL STRUCTURE; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DNA DEGRADATION; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROBLASTOMA CELL; OVARY CANCER; OXIDATIVE STRESS; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; CHEMISTRY; ENZYMOLOGY; METABOLISM; NEUROBLASTOMA; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALIA;

APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA; ENZYME ACTIVATION; FERRIC COMPOUNDS; HUMANS; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIALS; NEUROBLASTOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES;

EID: 79955759980     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019049     Document Type: Article

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