Pluripotency regulators in human mesenchymal stem cells: Expression of NANOG but not of OCT-4 and SOX-2

Stem Cells and Development

Volumn 20, Issue 5, 2011, Pages 915-923

  Pierantozzi, Enrico ^a   Gava, Barbara ^a   Manini, Ivana ^a   Roviello, Franco ^b   Marotta, Giuseppe ^b   Chiavarelli, Mario ^b   Sorrentino, Vincenzo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MESENCHYMAL STEM CELL; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ADULT; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CULTURE MEDIA; GENE EXPRESSION; HOMEODOMAIN PROTEINS; HUMANS; MESENCHYMAL STEM CELLS; MULTIPOTENT STEM CELLS; MYOCARDIUM; OCTAMER TRANSCRIPTION FACTOR-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOXB1 TRANSCRIPTION FACTORS; TIME FACTORS;

EID: 79955758537     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2010.0353     Document Type: Article

References (49)

1. Friedenstein AJ, II Piatetzky-Shapiro and KV Petrakova. (1966). Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 16:381-390.
2. Pittenger MF, AM Mackay, SC Beck, RK Jaiswal, R Douglas, JD Mosca, et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147. (Pubitemid 29282067)
3. Zuk PA, M Zhu, H Mizuno, DA De Ugarte, JI Huang, H Mizuno, et al. (2001). Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7:211-228. (Pubitemid 32295155)
4. Beltrami AP, D Cesselli, N Bergamin, P Marcon, S Rigo, E Puppato, et al. (2007). Multipotent cells can be generated in vitro from several adult human organs (heart, liver and bone marrow). Blood 110:3438-3446. (Pubitemid 350106340)
5. Gallo R, F Gambelli, B Gava, F Sasdelli, V Tellone, M Masini, et al. (2007). Generation and expansion of multipotent mesenchymal progenitor cells from cultured human pancreatic islets. Cell Death Differ 14:1860-1861.
6. Dezawa M, H Ishikawa, Y Itokazu, T Yoshihara, M Hoshino, S Takeda, et al. (2005). Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science 309:314-317. (Pubitemid 40967871)
7. Bonab MM, K Alimoghaddam, F Talebian, SH Ghaffari, A Ghavamzadeh and B Nikbin. (2006). Aging of mesenchymal stem cell in vitro. BMC Cell Biol 10:7-14.
8. Izadpanah R, D Kaushal, C Kriedt, F Tsien, B Patel, J Dufour, et al. (2008). Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. Cancer Res 68:4229-4238.
9. Muraglia A, R Cancedda and R Quarto. (2000). Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci 113:1161-1166. (Pubitemid 30229533)
10. Russell KC, DG Phinney, MR Lacey, BL Barrilleaux, KE Meyertholen and KC O'Connor. (2010). In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells 28:788-798.
11. Kolf CM, E Cho and RS Tuan. (2007). Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 9:204.
12. Song L, NE Webb, Y Song and RS Tuan. (2006). Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells 24:1707-1718. (Pubitemid 44474184)
13. Liu TM, M Martina, DW Hutmacher, JH Hui, EH Lee and B Lim. (2007). Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 25:750-760. (Pubitemid 46354235)
14. Mitchell JB, K McIntosh, S Zvonic, S Garrett, ZE Floyd, A Kloster, et al. (2006). Immunophenotype of human adiposederived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 24:376-385. (Pubitemid 44464807)
15. Doherty JM, MJ Geske, TS Stappenbeck and JC Mills. (2008). Diverse adult stem cells share specific higher-order patterns of gene expression. Stem Cells 26:2124-2130.
16. Wagner W, F Wein, A Seckinger, M Frankhauser, U Wirkner, U Krause, et al. (2005). Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood. Exp Hematol 33:1402-1416. (Pubitemid 41541969)
17. Hong JH, ES Hwang, MT McManus, A Amsterdam, Y Tian, R Kalmukova, et al. (2005). TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309:1074-1078. (Pubitemid 41134465)
18. Boiani M and HR Schö ler. (2005). Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 6:872-884. (Pubitemid 41568736)
19. Boyer LA, TI Lee, MF Cole, SE Johnstone, SS Levine, JP Zucker, et al. (2005). Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947-956. (Pubitemid 41345211)
20. Riekstina U, I Cakstina, V Parfejevs, M Hoogduijn, G Jankovskis, I Muiznieks, et al. (2009). Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis. Stem Cell Rev 5:378-386.
21. Greco SJ, K Liu and P Rameshwar. (2007). Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells 25:3143-3154. (Pubitemid 350294440)
22. Go MJ, C Takenaka and H Ohgushi. (2008). Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp Cell Res 314:1147-1154.
23. Pochampally RR, JR Smith, J Ylostalo and DJ Prockop. (2003). Serum deprivation of human marrow stromal cells (hMSCs) selects for a subpopulation of early progenitor cells with enhanced expression of OCT-4 and other embryonic genes. Blood 103:1647-1652. (Pubitemid 38268955)
24. Izadpanah R, C Trygg, B Patel, C Kriedt, J Dufour, JM Gimble, et al. (2006). Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 99:1285-1297.
25. Roche S, MJ Richard, MC Favrot, et al. (2007). Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression. J Cell Biochem 101:271-280. (Pubitemid 46698863)
26. Berg JS and MA Goodell. (2007). An argument against a role for Oct4 in somatic stem cells. Cell Stem Cell 1:359-360. (Pubitemid 47506541)
27. Liedtke S, J Enczmann, S Waclawczyk, P Wernet and G Kö gler. (2007). Oct4 and its pseudogenes confuse stem cell research. Cell Stem Cell 1:364-366. (Pubitemid 47506539)
28. Kaltz N, A Funari, S Hippauf, B Delorme, D Noël, M Riminucci, et al. (2008). In-vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes. Stem Cells 26:2419-2424.
29. Lengner CJ, FD Camargo, K Hochedlinger, GG Welstead, S Zaidi, S Gokhale, et al. (2007). Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1:403-415. (Pubitemid 47506536)
30. Kochupurakkal BS, R Sarig, O Fuchs, D Piestun, G Rechavi, D Givol, et al. (2008). Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. Biochem Biophys Res Commun 365:846-850. (Pubitemid 350234869)
31. Liu TM, YN Wu, XM Guo, JH Hui, EH Lee, and B Lim. (2009). Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev 18:1013-1022.
32. Ezeh UI, PJ Turek, RA Reijo and AT Clark. (2005). Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 104:2255-2265. (Pubitemid 41579973)
33. Piestun, D, BS Kochupurakkal, J Jacob-Hirsch, S Zeligson, M Koudritsky, E Domany, et al. (2006). Nanog transforms NIH3T3 cells and targets cell-type restricted genes. Biochem Biophys Res Commun 343:279-285.
34. Jeter CR, M Badeaux, G Choy, D Chandra, L Patrawala, C Liu, et al. (2009). Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 27:993-1005.
35. In't Anker PS, WA Noort, SA Scherjon, C Kleijburg-van der Keur, AB Kruisselbrink, RL van Bezooijen, et al. (2003). Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential. Haematologica 88:845-852. (Pubitemid 37128084)
36. Gregory CA, WG Gunn, A Peister and DJ Prockop. (2004). An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem 329:77-84. (Pubitemid 38596903)
37. Takeda J, S Seino and GI Bell. (1992). Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues. Nucleic Acids Res 20:4613-4620.
38. Booth HA and PW Holland. (2004). Eleven daughters of NANOG. Genomics 84:229-238. (Pubitemid 38834162)
39. Sacchetti B, A Funari, S Michienzi, S Di Cesare, S Piersanti, I Saggio, et al. (2007). Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131:324-336. (Pubitemid 47592917)
40. Crisan, M, S Yap, L Casteilla, CW Chen, M Corselli, TS Park, et al. (2008). A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3:301-313.
41. Phinney DG and DJ Prockop. (2007). Concise review: mesenchymal stem=multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 25:2896-2902. (Pubitemid 350127874)
42. Guilak F, KE Lott, HA Awad, Q Cao, KC Hicok, B Fermor and JM Gimble. (2006). Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. J Cell Physiol 206:229-237. (Pubitemid 41740736)
43. da Silva Meirelles L, AI Caplan and NB Nardi. (2008). In search of the in vivo identity of mesenchymal stem cells. Stem Cells 26:2287-2299.
44. Chambers I, J Silva, D Colby, J Nichols, B Nijmeijer, M Robertson, et al. (2007). Nanog safeguards pluripotency and mediates germline development. Nature 450:1230-1234.
45. Takahashi K, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda and Yamanaka S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872. (Pubitemid 350138099)
46. Silva J, O Barrandon, J Nichols, J Kawaguchi, TW Theunissen and A Smith. (2008). Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 6:e253.
47. Silva J, J Nichols, TW Theunissen, G Guo, van Oosten, AL, O Barrandon, et al. (2009). Nanog is the gateway to the pluripotent ground state. Cell 138:722-737.
48. Watt FM and BL Hogan. (2000). Out of Eden: stem cells and their niches. Science 287:1427-1430. (Pubitemid 30127126)
49. Spradling A, D Drummond-Barbosa and T Kai. (2001). Stem cells find their niche. Nature 4:98-104. (Pubitemid 33041633)