Immunological tolerance in a mouse model of immune-mediated liver injury induced by 16,16 dimethyl PGE2 and PGE2-containing nanoscale hydrogels

Biomaterials

Volumn 32, Issue 21, 2011, Pages 4925-4935

  Okamoto, Tatsuya ^a,b,c   Saito, Takashi ^c   Tabata, Yasuhiko ^c   Uemoto, Shinji ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Immunological tolerance; Liver; Nanoparticle (nanogel); PGE2

Indexed keywords

AMPHIPHILIC POLYMERS; ANTI-INFLAMMATORIES; CELL TRANSPLANTATION; CHRONIC TOXICITY; CONCANAVALIN A; CYTOKINES; EICOSANOIDS; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE AGENT; IN-VIVO; KUPFFER CELLS; L-LACTIC ACID; LIFE-TIMES; LIVER INJURIES; MALE MOUSE; MOUSE MODELS; NANO SCALE; NANO-SIZED; NANOGELS; PGE2; PRE-TREATMENT; PULLULANS; THERAPEUTIC AGENTS; UNDERLYING MECHANISM;

HYDROGELS; IMMUNOLOGY; LACTIC ACID; MAMMALS; NANOSTRUCTURED MATERIALS; OLIGOMERS; TOXICITY;

LIVER;

16,16 DIMETHYLPROSTAGLANDIN E2; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; LACTIC ACID; MESSENGER RNA; NANOPARTICLE; OLIGOMER; PROSTAGLANDIN E2; PULLULAN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; GENE EXPRESSION; HYDROGEL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; KUPFFER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL;

ANIMALS; BIOCOMPATIBLE MATERIALS; CONCANAVALIN A; DINOPROSTONE; GLUCANS; HYDROGELS; IMMUNE TOLERANCE; LACTIC ACID; LIVER; MALE; MATERIALS TESTING; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NANOSTRUCTURES; POLYMERS;

MUS;

EID: 79955748020     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.028     Document Type: Article

References (25)

1. Takatsuki M., Uemoto S., Inomata Y., Egawa H., Kiuchi T., Fujita S., et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 2002, 72:449-454.
2. Rao V.K., Burris D.E., Gruel S.M., Sollinger H.W., Burlingham W.J. Evidence that donor spleen cells administered through the portal vein prolong the survival of cardiac allografts in rats. Transplantation 1988, 45:1145-1146.
3. Gorczynski R.M., Chan Z., Chung S., Cohen Z., Levy G., Sullivan B., et al. Prolongation of rat small bowel or renal allograft survival by pretransplant transfusion and/or by varying the route of allograft venous drainage. Transplantation 1994, 58:816-820.
4. Kaneko Y., Harada M., Kawano T., Yamashita M., Shibata Y., Gejyo F., et al. Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 2000, 191:105-114.
5. Erhardt A., Biburger M., Papadopoulos T., Tiegs G. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology 2007, 45(2):475-485.
6. You Q., Cheng L., Kedl R.M., Ju C. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology 2008, 48:978-990.
7. Kabashima K., Saji T., Murata T., Nagamachi M., Matsuoka T., Segi E., et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 2002, 109:883-893.
8. Kunikata T., Yamane H., Segi E., Matsuoka T., Sugimoto Y., Tanaka S., et al. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol 2005, 6:524-531.
9. Vukicevic S., Simic P., Borovecki F., Grgurevic L., Rogic D., Orlic I., et al. Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. Kidney Int 2006, 70:1099-1106.
10. Yin H., Cheng L., Langenbach R., Ju C. Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury. Hepatology 2007, 45:159-169.
11. Ishihara T, Takahashi M, Higaki M, Takenaga M, Mizushima T, Mizushima Y. Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles. Pharm Res 20087; 25:1686-1695.
12. Katz S.C., Pillarisetty V.G., Bleier J.I., Shah A.B., DeMatteo R.P. Liver sinusoidal endothelial cells are insufficient to activate T cells. J Immunol 2004, 173:230-235.
13. Riley J.L., June C.H., Blazar B.R. Human T regulatory cell therapy. Take a billion or so and call me in the morning. Immunity 2009, 30:656-665.
14. Yoshimura A., Naka T., Kubo M. SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 2007, 7:454-465.
15. Ohta S., Nakamuta M., Fukushima M., Kohjima M., Kotoh K., Enjoji M., et al. Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin A-induced liver injury in mice. Liver Int 2005, 25:1061-1068.
16. Goessling W., North T.E., Loewer S., Lord A.M., Lee S., Stoick-Cooper C.L., et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 2009, 136:1136-1147.
17. Koga K., Takaesu G., Yoshida R., Nakaya M., Kobayashi T., Kinjyo I., et al. Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity 2009, 30:372-383.
18. Watzer B., Zehbe R., Halstenberg S., James Kirkpatrick Brochhausen C., Brochhausen C. Stability of prostaglandin E(2) (PGE (2)) embedded in poly-D, L: -lactide-co-glycolide microspheres: a pre-conditioning approach for tissue engineering applications. J Mater Sci Mater Med 2009, 20:1357-1365.
19. Akiyoshi K., Deguchi S., Moriguchi N., Yamaguchi S., Sunamoto J. Self-aggregates of hydrophobized polysaccharides in water - formation and characteristics of nanoparticles. Macromolecules 1993, 26:3062-3068.
20. Nagahama K., Mori Y., Ohya Y., Ouchi T. Biodegradable nanogel formation of polylactide-grafted dextran copolymer in dilute aqueous solution and enhancement of its stability by stereocomplexation. Biomacromolecules 2007, 8:2135-2141.
21. Miyazaki N., Tabata Y. Anti-tumor activity of carmofur water-solubilized by lactic acid oligomer-grafted pullulan nanogels. J Nanosci Nanotechnol 2009, 9:4797-4804.
22. Akiyoshi K., Taniguchi I., Fukui H., Sunamoto J. Hydrogel nanoparticle formed by self-assembly of hydrophobized polysaccharide, stabilization of adriamycin by complexation. Eur J Pharm Biopharm 1996, 42:286-290.
23. Kobayashi H., Katakura O., Morimoto N., Akiyoshi K., Kasugai S. Effects of cholesterol-bearing pullulan (CHP)-nanogels in combination with prostaglandin E1 on wound healing. J Biomed Mater Res B Appl Biomater 2009, 91:55-60.
24. Kato N., Hasegawa U., Morimoto N., Saita Y., Nakashima K., Ezura Y., et al. Nanogel-based delivery system enhances PGE2 effects on bone formation. J Cell Biochem 2007, 101:1063-1070.
25. Hubbell J.A., Thomas S.N., Swartz M.A. Materials engineering for immunomodulation. Nature 2009, 462:449-460.