Interaction of bestrophin-1 and Ca2+ channel β-subunits: Identification of new binding domains on the bestrophin-1 C-terminus

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Milenkovic, Vladimir M ^a   Krejcova, Sarka ^b   Reichhart, Nadine ^a   Wagner, Andrea ^a   Strauß, Olaf ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANION CHANNEL; BESTROPHIN 1; CALCIUM CHANNEL; CALCIUM CHANNEL BETA3 SUBUNIT PROTEIN; CALCIUM CHANNEL BETA4 SUBUNIT PROTEIN; CALCIUM CHANNEL CAV1.3; CALCIUM ION; CELL MEMBRANE PROTEIN; PROTEIN SH3; UNCLASSIFIED DRUG; BEST1 PROTEIN, HUMAN; CHLORIDE CHANNEL; EYE PROTEIN;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CALCIUM CURRENT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE ACTIVATION; GENE CLUSTER; GENE LOCATION; GENETIC CONSERVATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROLINE RICH PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REACTION TIME; WILD TYPE; ANIMAL; CELL STRAIN HEK293; CHEMISTRY; CHO CELL; CONFOCAL MICROSCOPY; CRICETULUS; HAMSTER; METHODOLOGY; PATCH CLAMP; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; CALCIUM CHANNELS; CHLORIDE CHANNELS; CHO CELLS; CRICETINAE; CRICETULUS; EYE PROTEINS; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 79955747549     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019364     Document Type: Article

References (40)

1. Hartzell HC, Qu Z, Yu K, Xiao Q, Chien LT, (2008) Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Physiol Rev 88: 639-672.
2. Burgess R, Millar ID, Leroy BP, Urquhart JE, Fearon IM, et al. (2008) Biallelic mutation of BEST1 causes a distinct retinopathy in humans. Am J Hum Genet 82: 19-31.
3. Rosenthal R, Bakall B, Kinnick T, Peachey N, Wimmers S, et al. (2006) Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cells. FASEB J 20: 178-180.
4. Yu K, Xiao Q, Cui G, Lee A, Hartzell HC, (2008) The best disease-linked Cl- channel hBest1 regulates Ca V 1 (L-type) Ca2+ channels via src-homology-binding domains. J Neurosci 28: 5660-5670.
5. Reichhart N, Milenkovic VM, Halsband CA, Cordeiro S, Strauss O, (2010) Effect of bestrophin-1 on L-type Ca(2+) channel activity depends on the Ca(2+) channel beta-subunit. Exp Eye Res 91: 630-639.
6. Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J, (2005) International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 57: 411-425.
7. Striessnig J, Hoda JC, Koschak A, Zaghetto F, Mullner C, et al. (2004) L-type Ca2+ channels in Ca2+ channelopathies. Biochem Biophys Res Commun 322: 1341-1346.
8. Dolphin AC, (2009) Calcium channel diversity: multiple roles of calcium channel subunits. Curr Opin Neurobiol 19: 237-244.
9. Richards MW, Butcher AJ, Dolphin AC, (2004) Ca2+ channel beta-subunits: structural insights AID our understanding. Trends Pharmacol Sci 25: 626-632.
10. Marmorstein AD, Kinnick TR, (2007) Focus on molecules: bestrophin (best-1). Exp Eye Res 85: 423-424.
11. Marquardt A, Stohr H, Passmore LA, Kramer F, Rivera A, et al. (1998) Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease). Hum Mol Genet 7: 1517-1525.
12. Petrukhin K, Koisti MJ, Bakall B, Li W, Xie G, et al. (1998) Identification of the gene responsible for Best macular dystrophy. Nat Genet 19: 241-247.
13. Renner AB, Tillack H, Kraus H, Kramer F, Mohr N, et al. (2005) Late onset is common in best macular dystrophy associated with VMD2 gene mutations. Ophthalmology 112: 586-592.
14. Arden GB, Constable PA, (2006) The electro-oculogram. Prog Retin Eye Res 25: 207-248.
15. Gallemore RP, Steinberg RH, (1989) Effects of DIDS on the chick retinal pigment epithelium. II. Mechanism of the light peak and other responses originating at the basal membrane. J Neurosci 9: 1977-1984.
16. Marmorstein LY, Wu J, McLaughlin P, Yocom J, Karl MO, et al. (2006) The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1). J Gen Physiol 127: 577-589.
17. Wu J, Marmorstein AD, Striessnig J, Peachey NS, (2007) Voltage-dependent calcium channel CaV1.3 subunits regulate the light peak of the electroretinogram. J Neurophysiol 97: 3731-3735.
18. Strauss O, (2005) The retinal pigment epithelium in visual function. Physiol Rev 85: 845-881.
19. Mullins RF, Kuehn MH, Faidley EA, Syed NA, Stone EM, (2007) Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease. Invest Ophthalmol Vis Sci 48: 3372-3380.
20. Mullins RF, Oh KT, Heffron E, Hageman GS, Stone EM, (2005) Late development of vitelliform lesions and flecks in a patient with best disease: clinicopathologic correlation. Arch Ophthalmol 123: 1588-1594.
21. Bakall B, Radu RA, Stanton JB, Burke JM, McKay BS, et al. (2007) Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Exp Eye Res 85: 34-43.
22. Frangieh GT, Green WR, Fine SL, (1982) A histopathologic study of Best's macular dystrophy. Arch Ophthalmol 100: 1115-1121.
23. O'Gorman S, Flaherty WA, Fishman GA, Berson EL, (1988) Histopathologic findings in Best's vitelliform macular dystrophy. Arch Ophthalmol 106: 1261-1268.
24. Weingeist TA, Kobrin JL, Watzke RC, (1982) Histopathology of Best's macular dystrophy. Arch Ophthalmol 100: 1108-1114.
25. Rosenthal R, Heimann H, Agostini H, Martin G, Hansen LL, et al. (2007) Ca2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease. Mol Vis 13: 443-456.
26. Abramoff MD, Magelhaes PJ, Ram SJ, (2004) Image processing with image. J Biophotonics Int 11: 36-42.
27. Fan J, Yuan Y, Palade P, (2001) FPL-64176 modifies pore properties of L-type Ca(2+) channels. Am J Physiol Cell Physiol 280: C565-572.
28. Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, et al. (2001) alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem 276: 22100-22106.
29. Michna M, Knirsch M, Hoda JC, Muenkner S, Langer P, et al. (2003) Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of mice. J Physiol 553: 747-758.
30. Singh A, Gebhart M, Fritsch R, Sinnegger-Brauns MJ, Poggiani C, et al. (2008) Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain. J Biol Chem 283: 20733-20744.
31. Milenkovic VM, Soria RB, Aldehni F, Schreiber R, Kunzelmann K, (2009) Functional assembly and purinergic activation of bestrophins. Pflugers Arch 458: 431-441.
32. Dolphin AC, (2003) Beta subunits of voltage-gated calcium channels. J Bioenerg Biomembr 35: 599-620.
33. Chen YH, Li MH, Zhang Y, He LL, Yamada Y, et al. (2004) Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature 429: 675-680.
34. Opatowsky Y, Chen CC, Campbell KP, Hirsch JA, (2004) Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron 42: 387-399.
35. Van Petegem F, Clark KA, Chatelain FC, Minor DL Jr, (2004) Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 429: 671-675.
36. Buraei Z, Yang J, The b subunit of voltage-gated Ca2+ channels. Physiol Rev 90: 1461-1506.
37. Cross HE, Bard L, (1974) Electro-oculography in Best's macular dystrophy. Am J Ophthalmol 77: 46-50.
38. Wabbels B, Preising MN, Kretschmann U, Demmler A, Lorenz B, (2006) Genotype-phenotype correlation and longitudinal course in ten families with Best vitelliform macular dystrophy. Graefes Arch Clin Exp Ophthalmol 244: 1453-1466.
39. Karl MO, Kroeger W, Wimmers S, Milenkovic VM, Valtink M, et al. (2008) Endogenous Gas6 and Ca2+-channel activation modulate phagocytosis by retinal pigment epithelium. Cell Signal 20: 1159-1168.
40. Wimmers S, Karl MO, Strauss O, (2007) Ion channels in the RPE. Prog Retin Eye Res 26: 263-301.