Transient cytotoxicity of 131I beta radiation in hyperthyroid patients treated with radioactive iodine

Indian Journal of Medical Research

Volumn 133, Issue 4, 2011, Pages 401-406

  Shanmuga Sundaram, P ^a   Padma, S ^a   Sudha, S ^b   Sasikala, K ^c  

^a AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

^b KARPAGAM UNIVERSITY   (India)

^c BHARATHIAR UNIVERSITY   (India)

Author keywords

Chromosomal aberrations; Hyperthyroidism; Low dose 131I therapy; Micronucleus assay

Indexed keywords

CARBIMAZOLE; IODINE 131; RADIOACTIVE IODINE; SODIUM IODIDE I 131;

ADULT; ARTICLE; AUTONOMOUS TOXIC NODULE; BETA RADIATION; BLOOD SAMPLING; CELL DAMAGE; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; CYTOTOXICITY; DRUG SAFETY; FEMALE; GRAVES DISEASE; HUMAN; HUMAN CELL; HYPERTHYROIDISM; LOW DRUG DOSE; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; PERIPHERAL LYMPHOCYTE; RADIATION DOSE; TOXIC GOITER; ELECTRON; METABOLISM; METHODOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOLOGY; RADIATION EXPOSURE; THYROID GLAND;

ADMINISTRATION, ORAL; ADULT; BETA PARTICLES; CHROMOSOME ABERRATIONS; HUMANS; HYPERTHYROIDISM; IODINE RADIOISOTOPES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; RADIATION DOSAGE; THYROID GLAND;

EID: 79955739220     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. 131 in the diagnosis and treatment of metastatic well differentiated thyroid cancer. Endocrinol Metab Clin North Am 1990; 19: 685-718.
2. Howarth D, Epstein M, Lan L, Tan P, Booker J. Determination of the optimal minimum radioiodine dose in patients with Graves' disease: a clinical outcome study. Eur J Nucl Med 2001; 28: 1489-95.
3. 124I PET and 3-dimensional-internal dosimetry (3D-ID) software. J Nucl Med 2004; 45: 1366-72.
4. 131 and 99mTc MIBI administration. Nucl Med Commun 2010; 134: 307-10.
5. Blackwell N, Stevenson AC, Wiernik G. chromosomal fndings in patients treated with small doses of iodine-131. Mutat Res 1974; 25: 397-402.
6. Fenech M. The in vitro micronuleus technique. Mutat Res 2000; 455: 81-95.
7. Gutiérrez S, carbonell E, Galofré P, creus A, Marcos R. Cytogenetic damage after 131-iodine treatment for hyperthyroidism and thyroid cancer. Eur J Nucl Med 1999; 26: 1589-96.
8. nd ed. London: Taylor & Francis Ltd.; 1983. p. 111-25, 147-76.
9. Holst JP, Burman KD, Atkins F, Umans JG, Jonklaas J. Radioiodine therapy for thyroid cancer and hyperthyroidism in patients with end-stage renal disease on hemodialysis. Thyroid 2005; 15: 1321-31.
10. Moorhead PS, Novell Pc, Mellman WJ, Battips DM, Hungerford DA. Chromosome preparation of leukocyte culture from peripheral blood. Exp Cel Res 1960; 20: 613-5.
11. Hungerford DA. Pachytene chromosome maps of human chromosomes 19 and 20. Cytogenet Cell Genet 1960; 27: 97-200.
12. WHO. Guidelines for the study of genetic effects in human populations, Environmental Health criteria, No. 46. Geneva: World Health Organization; 1985.
13. Fenech M, Morley AA. Measurement of micronuclei in human lymphocytes Mutat Res1983; 148: 29-36.
14. countryman PI, Heddle JA, The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutat Res 1976; 41: 321-32.
15. Eric Hall, Amato J. Giaccia. Radiobiology for the radiologist, 6th ed. Philadelphia, USA: Lippincott Wilkins & Williams; 2006. p. 16-28.
16. Gutiérrez S, carbonell E, Galofré P, creus A, Marcos R. Micronuclei induction by 131I exposure. Study in hyperthyroidism patients. Mutat Res 1997; 373: 39-45.
17. Ramirez MJ, Puerto S, Galofre P, Parry EM, Parry JM, creus A, et al. Multicolour FISH detection if radioactive iodine induced 17ce-p53 chromosomal breakages in buccal cells from therapeutically exposed patients. Carcinogenesis 2000; 21: 1581-6.
18. Gutierrez S, carbonell E, Galofre P, creus A, Marcos R. cytogenetic damage after 131-iodine treatment for hyperthyroidism and thyroid cancer. A study using the micronucleus test. Euro J Nuc Med 1999; 26: 1589-96.
19. Heddle JA, Cimino Mc, Hayashi M, Romagna F, Shelby MD, Tucker JD, et al. Micronuclei as anindex of cytogenetic damage: past, present and future. Environ Mol Mutagen 1991; 18: 277-91.
20. Müller WU, Nüsse M, Miller BM, Slavotinek A, Viaggi S, Streffer c. Micronuclei: a biological indicator of radiation damage. Mutat Res 1996; 366: 163-9.
21. 131 therapy for thyroid cancer using the micronucleus assay. J Nucl Med 1998; 39: 436-40.
22. Buckton KE, Evans HJ. Methods for the analysis of human chromosome aberrations. Geneva: World Health Organization; 1973. p. 21-2.