Deciphering the roles of C2-domain-containing proteins (synaptotagmins and otoferlin) in the inner ear

Journal of Neuroscience

Volumn 31, Issue 13, 2011, Pages 4765-4767

  Gregory, Frederick D ^a,b   Quiñones, Patricia M ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; OTOFERLIN; SYNAPTOTAGMIN; SYNAPTOTAGMIN I; SYNAPTOTAGMIN II; SYNAPTOTAGMIN VII; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; ENDOCYTOSIS; EXOCYTOSIS; HAIR CELL; HEARING IMPAIRMENT; INNER EAR; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNAPSE VESICLE;

EID: 79955712665     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6359-10.2011     Document Type: Article

References (26)

1. Beurg M, Safieddine S, Roux I, Bouleau Y, Petit C, Dulon D (2008) Calcium- and otoferlindependent exocytosis by immature outer hair cells. J Neurosci 28:1798-1803.
2. Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D (2010) Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J Neurosci 30:13281-13290.
3. 2+ and K+ channels in rodent inner hair cells. J Neurosci 27:3174-3186.
4. Dulon D, Safieddine S, Jones SM, Petit C (2009) Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. J Neurosci 29:10474-10487.
5. 2+ signals and their heterogeneity in hair cells. Proc Natl Acad Sci U S A 106:4483-4488.
6. Goodyear RJ, Legan PK, Christiansen JR, Xia B, Korchagina J, Gale JE, Warchol ME, Corwin JT, Richardson GP (2010) Identification of the hair cell soma-1 antigen, HCS-1, as otoferlin. J Assoc Res Otolaryngol 11:573-586.
7. 2+ sensor for spontaneous neurotransmitter release. Science 327:1614-1618.
8. Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (2008) Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form. Hum Mol Genet 17:3814-3821.
9. Heidrych P, Zimmermann U, Kuhn S, Franz C, Engel J, Duncker SV, Hirt B, Pusch CM, Ruth P, Pfister M, Marcotti W, Blin N, Knipper M (2009) Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. Hum Mol Genet 18:2779-2790.
10. Johnson CP, Chapman ER (2010) Otoferlin is a calcium sensor that directly regulates SNARE mediated membrane fusion. J Cell Biol 191:187-197.
11. Johnson SL, Franz C, Knipper M, Marcotti W (2009) Functional maturation of the exocytotic machinery at gerbil hair cell ribbon synapses. J Physiol 587:1715-1726.
12. 2+ dependence of vesicle fusion at auditory ribbon synapses. Nat Neurosci 13:45-52.
13. Liberman MC (1982) Single-neuron labeling in the cat auditory nerve. Science 216:1239-1241.
14. Longo-Guess C, Gagnon LH, Bergstrom DE, Johnson KR (2007) A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9. Hear Res 234:21-28.
15. 2+-triggered exocytosis. Curr Opin Cell Biol 22:496-505.
16. Pangrsic T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Brose N, Müller U, Reisinger E, Moser T (2010) Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci 13:869-876.
17. Ramakrishnan NA, Drescher MJ, Drescher DG (2009) Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltagegated calcium channel Cav1.3. J Biol Chem 284:1364-1372.
18. Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C (2006) Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell 127:277-289.
19. Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S (2009) Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses. Hum Mol Genet 18: 4615-4628.
20. Ruel J, Emery S, Nouvian R, Bersot T, Amilhon B, VanRybroek JM, Rebillard G, Lenoir M, Eybalin M, Delprat B, Sivakumaran TA, Giros B, El Mestikawy S, Moser T, Smith RJ, Lesperance MM, Puel JL (2008) Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice. Am J Hum Genet 83:278-292.
21. Safieddine S, Wenthold RJ (1999) SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteins. Eur J Neurosci 11:803-812.
22. Schmitz F, Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC (2006) CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. Proc Natl Acad Sci U S A 103:2926-2931.
23. Schug N, Braig C, Zimmermann U, Engel J, Winter H, Ruth P, Blin N, Pfister M, Kalbacher H, Knipper M (2006) Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat. Eur J Neurosci 24:3372-3380.
24. Schwander M, Sczaniecka A, Grillet N, Bailey JS, Avenarius M, Najmabadi H, Steffy BM, Federe GC, Lagler EA, Banan R, Hice R, Grabowski-Boase L, Keithley EM, Ryan AF, Housley GD, Wiltshire T, Smith RJ, Tarantino LM, Müller U (2007) A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. J Neurosci 27:2163-2175.
25. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH (2008) Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron 57:263-275.
26. Yasunaga S, Grati M, Cohen-Salmon M, El-Amraoui A, Mustapha M, Salem N, El-Zir E, Loiselet J, Petit C (1999) A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness. Nat Genet 21:363-369.