Decrease in Serum Adiponectin Levels Associated with Visceral Fat Accumulation Independent of Pubertal Stage in Children and Adolescents

Archives of Medical Research

Volumn 42, Issue 2, 2011, Pages 115-121

  Medina Bravo, Patricia ^a   Meza Santibáñez, Ruth ^c   Rosas Fernández, Patricia ^c   Galván Duarte, Rosa ^d   Saucedo García, Renata ^d   Velázquez López, Lubia ^d   Torres Tamayo, Margarita ^b  

^a HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^b HOSPITAL GENERAL DR MANUEL GEA GONZÁLEZ   (Mexico)

^c HOSPITAL DE PEDIATRÍA   (Mexico)

^d INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Adiponectin; Children; Metabolic abnormalities; Pubertal stage; Visceral fat

Indexed keywords

ADIPONECTIN; GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID BLOOD LEVEL; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; OBESITY; PREPUBERTY; PUBERTY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; SYSTOLIC BLOOD PRESSURE;

EID: 79955711079     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2011.03.002     Document Type: Article

References (44)

1. Freedman D.S., Katzmarzyk P.T., Dietz W.H., et al. Relation of body mass index and skinfold thicknesses to cardiovascular disease risk factors in children: the Bogalusa Heart Study. Am J Clin Nutr 2009, 90:210-216.
2. Juarez-Lopez C., Klunder-Klunder M., Medina-Bravo P., et al. Insulin resistance and its association with the components of the metabolic syndrome among obese children and adolescents. BMC Public Health 2010, 10:318.
3. Goran M.I., Ball G.D.C., Cruz M.L. Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 2003, 88:1417-1427.
4. Brufani C., Ciampalini P., Grossi A., et al. Glucose tolerance status in 510 children and adolescents attending an obesity clinic in Central Italy. Pediatric Diabetes 2010, 11:47-54.
5. Thomas R., Rainer W. Relationships between cardiovascular risk profile, ultrasonographic measurement of intra-abdominal adipose tissue, and waist circumference in obese children. Clin Nutr (Edinburgh, Scotland) 2010, 29:24-30.
6. Weiss R. Impaired glucose tolerance and risk factors for progression to type 2 diabetes in youth. Pediatric Diabetes 2007, 8:70-75.
7. Slyper A.H. Childhood obesity, adipose tissue distribution, and the pediatric practitioner. Pediatrics 1998, 102:e4.
8. Nedungadi T.P., Clegg D.J. Sexual dimorphism in body fat distribution and risk for cardiovascular diseases. J Cardiovasc Transl Res 2009, 2:321-327.
9. Liska D., Dufour S., Zern T.L., et al. Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents. PLoS ONE 2007, 2:e569.
10. Rattarasarn C., Leelawattana R., Soonthornpun S., et al. Gender differences of regional abdominal fat distribution and their relationships with insulin sensitivity in healthy and glucose-intolerant Thais. J Clin Endocrinol Metab 2004, 89:6266-6270.
11. Taksali S., Caprio S., Dziura J., et al. High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes 2008, 57:367-371.
12. Bacha F., Saad R., Gungor N., et al. Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. J Clin Endocrinol Metab 2003, 88:2534-2540.
13. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010, 316:129-139.
14. Punthakee Z., Delvin E.E., O'Loughlin J., et al. Adiponectin, adiposity, and insulin resistance in children and adolescents. J Clin Endocrinol Metab 2006, 91:2119-2125.
15. Yamauchi T., Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 2008, 32:13-18.
16. Weyer C., Funahashi T., Tanaka S., et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001, 86:930-1935.
17. Cote M., Mauriege P., Bergeron J., et al. Adiponectinemia in visceral obesity: impact on glucose tolerance and plasma lipoprotein and lipid levels in men. J Clin Endocrinol Metab 2005, 90:1434-1439.
18. Kuczmarski R.J., Ogden C.L., Guo S.S., et al. 2000 CDC growth charts for the United States: methods and development. National Center for Health Statistics. Vital Health Stat 2002, 11.
19. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
20. DeLong D.M., DeLong E.R., Wood P.D., Lippel K., Rifkind B.M. A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol. The Lipid Research Clinic Prevalence Study. JAMA 1986, 256:2372-2377.
21. Donnelly L.F., Emery K.H., Brody A.S., et al. Minimizing radiation dose for pediatric body applications of single-detector helical CT: strategies at a large children's Hospital. Am J Roentgenol 2001, 176:303-306.
22. Kobayashi J., Tadokoro N., Watanabe M., et al. A novel method of measuring intra-abdominal fat volume using helical computed tomography. Int J Obes 2002, 26:398-402.
23. Kobayashi J., Sasak T., Watanabe M. The relationship of abdominal fat mass assessed by helical or conventional computed tomography to serum leptin concentrations. J Atheroscler Thromb 2004, 11:173-179.
24. Wilda L. Conducting ANOVA Trend Analyses Using Polynomial Contrasts. Paper presented at the Annual Meeting of the Southwest Educational Research Association; January 23-25; Austin, TX; 1997.
25. Böttner A., Kratzsch J., Müller G., et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004, 89:4053-4061.
26. Tsou P.L., Jiang Y.D., Chang C.C., et al. Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care 2004, 27:308-313.
27. Stefan N., Bunt J.C., Salbe A.D., et al. Plasma adiponectin concentrations in children: relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002, 87:4652-4656.
28. Araki S., Dobashi K., Kubo K., et al. High molecular weight, rather than total adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J Clin Endocrinol Metab 2006, 91:5113-5116.
29. Combs T.P., Berg A.H., Rajala M.W., et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003, 52:268-276.
30. Asayama K., Hayashib H., Dobashi K., et al. Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res 2003, 11:1072-1079.
31. Weiss R., Taksali S.E., Dufour S., et al. The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning. J Clin Endocrinol Metab 2005, 90:3731-3737.
32. Cruz M., García-Macedo R., García-Valerio Y., et al. Low adiponectin levels predict type 2 diabetes in Mexican children. Diabetes Care 2004, 27:1451-1453.
33. Butte N.F., Comuzzie A.G., Cai G., et al. Genetic and environmental factors influencing fasting serum adiponectin in Hispanic children. J Clin Endocrinol Metab 2005, 90:4170-4176.
34. Broedl U.C., Lehrke M., Fleischer-Brielmaier E., et al. Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. Cardiovasc Diabetol 2006, 15:5-11.
35. Carroll J.F., Chiapa A.L., Rodriquez M., et al. Visceral fat, waist circumference, and BMI: impact of race/ethnicity. Obesity (Silver Spring) 2008, 16:600-607.
36. Lee S., Bacha F., Gungor N., et al. Racial differences in adiponectin in youth. Relationship to visceral fat and insulin sensitivity. Diabetes Care 2006, 29:51-56.
37. Brufani C., Tozzi A., Fintini D., et al. Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects. Eur J Endocrinol 2009, 160:769-775.
38. Brambilla P., Bedogni G., Moreno L.A., et al. Crossvalidation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. Int J Obes (Lond) 2006, 30:23-30.
39. Asayama K., Dobashi K., Hayashibe H., et al. Threshold values of visceral fat measures and their anthropometric alternatives for metabolic derangement in Japanese obese boys. Int J Obes 2002, 26:208-213.
40. Bacha F., Saad R., Gungor N., et al. Adiponectin in youth. Relationship to visceral adiposity, insulin sensitivity, and β-cell function. Diabetes Care 2004, 27:547-552.
41. Lebovitz H.E., Banerji M.A. Point: Visceral adiposity is causally related to insulin resistance. Diabetes Care 2005, 28:2322-2325.
42. Ventura E.E., Lane C.J., Weigensberg M.J., et al. Persistence of the metabolic syndrome over 3 annual visits in overweight Hispanic children: association with progressive risk for type 2 diabetes. J Pediatr 2009, 155. 535.e1-541.e1.
43. Toledo-Corral C.M., Ventura E.E., Hodis H.N., et al. Persistence of the metabolic syndrome and its influence on carotid artery intima media thickness in overweight Latino children. Atherosclerosis 2009, 206:594-598.
44. Arnaiz P., Acevedo M., Barja S., et al. Adiponectin levels, cardiometabolic risk factors and markers of subclinical atherosclerosis in children. Int J Cardiol 2010, 138:138-144.