Lactate transport and metabolism in the human brain: Implications for the astrocyte-neuron lactate shuttle hypothesis

Journal of Neuroscience

Volumn 31, Issue 13, 2011, Pages 4768-4770

  Figley, Chase R ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

AEROBIC METABOLISM; ARTICLE; ASTROCYTE; ASTROCYTE NEURON LACTATE SHUTTLE HYPOTHESIS; BRAIN CORTEX; BRAIN METABOLISM; CELL COMPARTMENTALIZATION; CITRIC ACID CYCLE; GLYCOLYSIS; LACTATE BLOOD LEVEL; LACTATE METABOLISM; LACTATE TRANSPORT; METABOLISM; NEUROSCIENCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; TRANSPORT AT THE CELLULAR LEVEL;

EID: 79955708439     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6612-10.2011     Document Type: Article

References (10)

1. Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S (2009) Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 513:532-541.
2. Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL (2010) The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci 30:13983-13991.
3. Caesar K, Hashemi P, Douhou A, Bonvento G, Boutelle MG, Walls AB, Lauritzen M (2008) Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo. J Physiol 586:1337-1349.
4. Figley CR, Stroman PW (2011) The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals. Eur J Neurosci 33:577-588.
5. Gandhi GK, Cruz NF, Ball KK, Dienel GA (2009) Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons. J Neurochem 111:522-536.
6. Gordon GR, Choi HB, Rungta RL, Ellis-Davies GC, MacVicar BA (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456:745-749.
7. Hyder F, Patel AB, Gjedde A, Rothman DL, Behar KL, Shulman RG (2006) Neuronalglial glucose oxidation and glutamatergic- GABAergic function. J Cereb Blood Flow Metab 26:865-877.
8. Mangia S, Giove F, Tkác I, Logothetis NK, Henry PG, Olman CA, Maraviglia B, Di Salle F, Ug̈urbil K (2009) Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings. J Cereb Blood Flow Metab 29:441-463.
9. Pellerin L, Bouzier-Sore AK, Aubert A, Serres S, Merle M, Costalat R, Magistretti PJ (2007) Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia 55:1251-1262.
10. Vaishnavi SN, Vlassenko AG, Rundle MM, Snyder AZ, Mintun MA, Raichle ME (2010) Regional aerobic glycolysis in the human brain. Proc Natl Acad Sci U S A 107:17757-17762.