Controlled evaluation of the effects of hyperbaric oxygen therapy on the behavior of 16 children with autism spectrum disorders

Journal of Autism and Developmental Disorders

Volumn 41, Issue 5, 2011, Pages 575-588

  Jepson, Bryan ^a   Granpeesheh, Doreen ^b   Tarbox, Jonathan ^b   Olive, Melissa L ^b   Stott, Carol ^a   Braud, Scott ^b,d   Yoo, J Helen ^b,c   Wakefield, Andrew ^a   Allen, Michael S ^b,e  

^a Thoughtful House Center for Children   (United States)

^b Center for Autism and Related Disorders   (United States)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^d HOPE Reach   (United States)

^e Connecticut Behavioral Heath ^*  (United States)

Author keywords

Autism; Behavioral pharmacology; Hyperbaric oxygen therapy

Indexed keywords

ADAPTIVE BEHAVIOR; ARTICLE; AUTISM; BEHAVIOR; BEHAVIOR DISORDER; CHILD; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HYPERBARIC OXYGEN; INTELLIGENCE QUOTIENT; LANGUAGE ABILITY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; STEREOTYPY; TREATMENT FAILURE; TREATMENT OUTCOME;

CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; FEMALE; HUMANS; HYPERBARIC OXYGENATION; MALE; PATIENT SELECTION; TREATMENT OUTCOME;

EID: 79955695207     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-010-1075-y     Document Type: Article

References (62)

1. Al-Waili, N. S., & Butler, G. J. (2006). Effects of hyperbaric oxygen on inflammatory response to wound and trauma: Possible mechanism of action. The Scientific World Journal, 6, 425-441.
2. Aman, M. G., & Singh, N. N. (1994). Aberrant behavior checklist-community: Supplementary manual. East Aurora, NY: Slosson Educational Publications.
3. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th edn, Text Revision). Washington, DC: American Psychiatric Association.
4. Anderson, D. C., Bottini, A. G., Jaqiella, W. M., Westphal, B., Ford, S., Rockswold, G. L., et al. (1991). A pilot study of hyperbaric oxygen in the treatment of human stroke. Stroke, 22, 1137-1142.
5. Ashwood, P., Anthony, A., Pellicer, A. A., Torrente, F., Walker-Smith, J. A., & Wakefield, A. J. (2003). Intestinal lymphocyte populations in children with regressive autism: Evidence for extensive mucosal immunopathology. Journal of Clinical Immunology, 23, 504-517. (Pubitemid 38177671)
6. Ashwood, P., Anthony, A., Torrente, F., & Wakefield, A. J. (2004). Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Clinical Immunology, 24, 664-673. (Pubitemid 40933118)
7. Autism Research Institute (2007). Autism Treatment Evaluation Checklist. Retrieved from http://autism.com/ari/atec/.
8. Balzola, F., Barbon, V., Repici, A., Rizzetto, M., Clauser, D., Gandione, M., et al. (2005). Panenteric IBD-like disease in a patient with regressive autism shown for the first time by the wireless capsule enteroscopy: Another piece in the jigsaw of this gut-brain syndrome? The American Journal of Gastroenterology, 100(4), 979-981. (Pubitemid 40592395)
9. Bennett, M., & Heard, R. (2004). Hyperbaric oxygen therapy for multiple sclerosis. Cochrane Database of Systematic Reviews, 1, CD003057.
10. Bennett, M. H., Trytko, B., & Jonker, B. (2004). Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury. Cochrane Database Systemic Reviews, 4, CD004609.
11. Buchman, A. L., Fife, C., Torres, C., Smith, L., & Aristizibal, J. (2001). Hyperbaric oxygen therapy for severe ulcerative colitis. Journal of Clinical Gastroenterology, 33, 337-339. (Pubitemid 32880978)
12. Cohen, I. L., & Sudhalter, V. (2005). The PDD behavior inventory. Lutz, FL: Psychological Assessment Resources, Inc.
13. Collet, J. P., Vanasse, M., Marois, P., Amar, M., Goldberg, J., Lambert, J., et al. (2001). Hyperbaric oxygen for children with cerebral palsy: A randomised multicentre trial. HBO-CP Research Group. Lancet, 357(9256), 582-586.
14. Crosland, K. A., Zarcone, J. R., Lindauer, S. E., Valdovinos, M. G., Zarcone, T. J., Hellings, J. A., et al. (2003). Use of functional analysis methodology in the evaluation of medication effects. Journal of Autism and Developmental Disorders, 33, 271-279. (Pubitemid 36919118)
15. Furlano, R. I., Anthony, A., Day, R., Brown, A., McGarvey, L., Thomson, M. A., et al. (2001). Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. The Journal of Pediatrics, 138, 366-372. (Pubitemid 32207139)
16. Gessell, L. B. (2008). Hyperbaric oxygen therapy indications. Durham, NC: Undersea and Hyperbaric Medical Society.
17. Gorgulu, S., Yagci, G., Kaymakcioglu, N., Ozkara, M., Kurt, B., Ozcan, A., et al. (2006). Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats. Digestive Diseases and Sciences, 51, 480-487.
18. Granpeesheh, D., Tarbox, J., Dixon, D., Wilke, A. E., Allen, S., & Bradstreet, J. J. (2010). Randomized trial of hyperbaric oxygen therapy for children with autism. Research in Autism Spectrum Disorders, 4, 265-268.
19. Green, V. A., Pituch, K. A., Itchon, J., Choi, A., O'Reilly, M., & Sigafoos, J. (2006). Internet survey of treatments used by parents of children with autism. Research in Developmental Disabilities, 27, 70-84.
20. Gulec, B., Yasar, M., Yildiz, S., Oter, S., Akay, C., Deveci, S., et al. (2004). Effect of hyperbaric oxygen on experimental acute distal colitis. Physiological Research, 53, 493-499. (Pubitemid 39486706)
21. Gurbuz, A. K., Elbuken, E., Yazgan, Y., & Yildiz, S. (2003a). A different therapeutic approach in patients with severe ulcerative colitis: Hyperbaric oxygen treatment. Southern Medical Journal, 96(6), 632-633. (Pubitemid 38281731)
22. Gurbuz, A. K., Elbuken, E., Yazgan, Y., & Yildiz, S. (2003b). A different therapeutic approach in severe ulcerative hyperbaric oxygen treatment. Romanian Journal of Gastroenterology, 12(2), 170-171. (Pubitemid 36827763)
23. Guy, W. (1976). Clinical global impression. ECDEU Assessment Manual for Psychopharmacology, revised. Rockville, MD: National Institute of Mental Health.
24. Hardy, P., Collet, J., Goldberg, J., Ducruet, T., Vanasse, M., Lambert, J., et al. (2002). Neuropsychological effects of hyperbaric oxygen therapy in cerebral palsy. Developmental Medicine and Child Neurology, 44(7), 436-446. (Pubitemid 34808751)
25. Helms, A. K., Whelan, H. T., & Torbey, M. T. (2005). Hyperbaric oxygen therapy of cerebral ischemia. Cerebrovascular Diseases, 20(6), 417-426. (Pubitemid 41675018)
26. Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135, 559-563. (Pubitemid 30180444)
27. Iwata, B. A., Dorsey, M. F., Slifer, K. J., Bauman, K. E., Richman, G. S. (1994). Toward a functional analysis of self-injury. Journal of Applied Behavior Analysis, 27, 197-209.
28. (Reprinted from Analysis and Intervention in Developmental Disabilities, 2, 3-20, 1982).
29. Jain, K. (2004). Textbook of hyperbaric medicine. Toronto: Hogrefe & Huber Pub.
30. Kazdin, A. E. (1982). Single-case research designs: Methods for clinical and applied settings. New York, NY: Oxford University Press.
31. Kleijnen, J., & Knipschild, P. (1995). Hyperbaric oxygen for multiple sclerosis. Review of controlled trials. Acta Neurologica Scandinavica, 91(5), 330-334.
32. Kogan, M. D., et al. (2009). Prevalence of parent-reported diagnosis of autism spectrum disorder among children in the US, 2007. Pediatrics, 124, 1395-1403.
33. Lerman, D. C., Sansbury, T., Hovanetz, A., Wolever, E., Garcia, A., O'Brien, E., et al. (2008). Using behavior analysis to examine the outcomes of unproven therapies: An evaluation of hyperbaric oxygen therapy for children with autism. Behavior Analysis in Practice, 1, 50-58.
34. Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., et al. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185-212. (Pubitemid 19176529)
35. McDonagh, M., Helfand, M., Carson, S., & Russman, B. S. (2004). Hyperbaric oxygen therapy for traumatic brain injury: A systematic review of the evidence. Archives of Physical Medicine and Rehabilitation, 85, 1198-1204. (Pubitemid 38962384)
36. McDonagh, M. S., Morgan, D., Carson, S., & Russman, B. S. (2007). Systematic review of hyperbaric oxygen therapy for cerebral palsy: The state of the evidence. Developmental Medicine and Child Neurology, 49(12), 942-947. (Pubitemid 350182562)
37. Nighoghossian, N., & Trouillas, P. (1995). Hyperbaric oxygen in the treatment of acute ischemic stroke. A double-blind pilot study. Stroke, 26(8), 1369-1372.
38. Nikfarjam, M., Cuthbertson, C. M., Malcontenti-Wilson, C., Muralidharen, V., Milar, I., & Christophi, C. (2007). Hyperbaric oxygen therapy reduces severity and improves survival in severe acute pancreatitis. Journal of Gastrointestinal Surgery, 11, 1008-1015.
39. Pardo, C. A., Vargas, D. L., & Zimmerman, A. W. (2005). Immunity, neuroglia and neuroinflammation in autism. International Review of Psychiatry, 17, 485-495. (Pubitemid 43086675)
40. Rockswold, S. B., Rockswold, G. L., & Defillo, A. (2007). Hyperbaric oxygen in traumatic brain injury. Neurological Research, 29, 162-172. (Pubitemid 46685269)
41. Rossignol, D. A. (2007). Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism. Medical Hypotheses, 68, 1208-1227.
42. Rossignol, D. A., & Rossignol, L. W. (2006). Hyperbaric oxygen therapy may improve symptoms in autistic children. Medical Hypotheses, 67, 216-228. (Pubitemid 43825617)
43. Rossignol, D. A., Rossignol, L. W., James, S. J., Melnyk, S., & Mumper, E. (2007). The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: An open-label pilot study. BMC Pediatrics, 7, 36.
44. Rossignol, D. A., Rossignol, L. W., Smith, S., Schneider, C., Logerquist, S., Usman, A., et al. (2009). Hyperbaric treatment for children with autism: A multicenter, randomized, double-blind, controlled trial. BMC Pediatrics, 9: doi: 10.1186/1471-2431-9-21.
45. Rusyniak, D. E., Kirk, M. A., Kao, L. W., Brizendine, E. J., Welch, J. L., Cordell, W. H., et al. (2003). Hyperbaric oxygen therapy in acute ischemic stroke: Results of the hyperbaric oxygen in acute ischemic stroke trial pilot study. Stroke, 34(2), 571-574. (Pubitemid 36206367)
46. Ryu, Y. H., Lee, J. D., Yoon, P. H., Kim, D. I., Lee, H. B., & Shin, Y. J. (1999). Perfusion impairments in infantile autism on technetium-99 m ethyl cysteinate dimer brain single-photon emission tomography: Comparison with findings on magnetic resonance imaging. European Journal of Nuclear Medicine, 26(3), 253-259. (Pubitemid 29139856)
47. Shi, X. Y., Tang, Z. Q., Sun, D., & He, X. J. (2006). Evaluation of hyperbaric oxygen treatment of neuropsychiatric disorders following traumatic brain injury. Chinese Medical Journal (Engl), 119, 1978-1982. (Pubitemid 46592055)
48. Singhal, A. B. (2007). A review of oxygen therapy in ischemic stroke. Neurological Research, 29(2), 173-183.
49. Sparrow, S., Cicchetti, D., & Balla, D. (2005). Vineland adaptive behavior scales (2nd ed.). Minneapolis, MN: Pearson Assessment.
50. Starkstein, S. E., Vazquez, S., Vrancic, D., Nanclares, V., Manes, F., Piven, J., et al. (2000). SPECT findings in mentally retarded autistic individuals. The Journal of Neuropsychiatry and Clinical Neurosciences, 12(3), 370-375. (Pubitemid 30663736)
51. Torrente, F., Ashwood, P., Day, R., Machado, N., Furlando, R. I., Anthony, A., et al. (2002). Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Molecular Psychiatry, 7(4) 375-382, 334.
52. Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67-81. (Pubitemid 40053317)
53. Vlodavsky, E., Palzur, E., & Soustiel, J. F. (2006). Hyperbaric oxygen therapy reduces neuroinflammation and expression of matrix metalloproteinase-9 in the rat model of traumatic brain injury. Neuropathology Applied Neurobiology, 32, 40-50.
54. Wakefield, A. J., Anthony, A., Murch, S. H., Thomson, M., Montgomery, S. M., Davies, S., et al. (2000). Enterocolitis in children with developmental disorders. The American Journal of Gastroenterology, 95(9), 2285-2295.
55. Wechsler, D. (1999). Wechsler abbreviated scale of intelligence (WASI). San Antonio, TX: Harcourt Assessment.
56. Wechsler, D. (2002). Wechsler primary and preschool scale of intelligence™-Third edition (WPPSI™-III). San Antonio, TX: Harcourt Assessment.
57. Wilcox, J., Tsuang, M. T., Ledger, E., Algeo, J., & Schnurr, T. (2002). Brain perfusion in autism varies with age. Neuropsychobiology, 46(1), 13-16. (Pubitemid 35002312)
58. Wilson, H. D., Wilson, J. R., & Fuchs, P. N. (2006). Hyperbaric oxygen treatment decreases inflammation and mechanical hypersensitivity in an animal model of inflammatory pain. Brain Research, 1098, 126-128. (Pubitemid 44277998)
59. Wilson, H. D., Toepfer, V. E., Senapati, A. K., Wilson, J. R., & Fuchs, P. N. (2007). Hyperbaric oxygen treatment is comparable to acetylsalicylic acid treatment in an animal model of arthritis. The Journal of Pain, 8, 924-930. (Pubitemid 350161434)
60. Zarcone, J. R., Lindauer, S. E., Morse, P. S., Crosland, K. A., Valdovinos, M. G., McKerchar, T., et al. (2004). Effects of risperidone on destructive behavior of persons with developmental disabilities: III. Functional analysis. American Journal on Mental Retardation, 109, 310-321. (Pubitemid 44132743)
61. Zarcone, J. R., Napolitano, D., & Valdovinos, M. (2008). Measurement of problem behaviour during medication evaluations. Journal of Intellectual Disability Research, 52, 1015-1028.
62. Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., et al. (2005). Cerebrospinal fluid and serum markers of inflammation in autism. Pediatric Neurology, 33(3), 195-201. (Pubitemid 41558217)