Identification and quantification of major steviol glycosides in stevia rebaudiana purified extracts by 1H NMR spectroscopy

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 9, 2011, Pages 4378-4384

  Pieri, Valerio ^a   Belancic, Andrea ^b   Morales, Susana ^b   Stuppner, Hermann ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Camino Internacional   (Chile)

Author keywords

QHNMR; Quality control; Rebaudioside A; Stevia rebaudiana; Steviol glycosides; Stevioside

Indexed keywords

QHNMR; REBAUDIOSIDE-A; STEVIA REBAUDIANA; STEVIOL GLYCOSIDES; STEVIOSIDES;

IDENTIFICATION (CONTROL SYSTEMS); NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PURIFICATION; QUALITY ASSURANCE; QUALITY CONTROL; SUGAR SUBSTITUTES; SUGARS;

GLYCOSIDES;

GLYCOSIDE; KAURANE DERIVATIVE; PLANT EXTRACT; STEVIOL;

ARTICLE; CHEMISTRY; EVALUATION; ISOLATION AND PURIFICATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEVIA;

DITERPENES, KAURANE; GLYCOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; PLANT EXTRACTS; STEVIA;

STEVIA REBAUDIANA;

EID: 79955692307     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf104922q     Document Type: Article

References (18)

1. European Food Safety Authority (EFSA), Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive. Available at: http://www.efsa.europa.eu/en/scdocs/doc/1537.pdf (accessed Nov 2010).
2. Mizutani, K.; Tanaka, O. Use of Stevia rebaudiana sweeteners in Japan. In Stevia: The Genus Stevia, 1st ed.; Kinghorn, A. D., Ed.; Taylor & Francis: London, 2002; pp 178-184.
3. Joint FAO/WHO Expert Committee on Food Additives (JECFA), Compendium of Food Additive Specifications. Monograph 10. Steviol glycosides. Available at: http://www.fao.org/ag/agn/jecfaadditives/specs/monograph10/additive-442-m10.pdf (accessed Nov 2010).
4. Joint FAO/WHO Expert Committee on Food Additives (JECFA), Compendium of Food Additive Specifications. Monograph 5. Steviol glycosides. Available at: http://www.fao.org/ag/agn/jecfaadditives/specs/monograph5/additive-442-m5.pdf (accessed Nov 2010).
5. Gardana, C.; Scaglianti, M.; Simonetti, P. Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry. J. Chromatogr., A 2010, 1217, 1463-1470.
6. Verpoorte, R.; Choi, Y. H.; Kim, H. K. NMR-based metabolomics at work in phytochemistry. Phytochem. Rev. 2007, 6, 3-14. (Pubitemid 46457327)
7. Pauli, G. F.; Jaki, B. U.; Lankin, D. C. Quantitative 1H NMR: development and potential of a method for natural products analysis. J. Nat. Prod. 2005, 68, 133-149. (Pubitemid 40175949)
8. 1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection. Metabolomics 2010, 6, 263-273.
9. Vitorge, B.; Bieri, S.; Humam, M.; Christen, P.; Hostettmann, K.; Munoz, O.; Loss, S.; Jeannerat, D. High-precision heteronuclear 2D NMR experiments using 10-ppm spectral window to resolve carbon overlap. Chem. Commun. 2009, 8, 950-952.
10. Maniara, G.; Rajamoorthi, K.; Rajan, S.; Stockton, G. W. Method performance and validation for quantitative analysis by 1H and 31P NMR spectroscopy. Applications to analytical standards and agricultural chemicals. Anal. Chem. 1998, 70, 4921-4928.
11. Kohda, H.; Kasai, R.; Yamasaki, K.; Murakami, K.; Tanaka, O. New sweet diterpene glucosides from Stevia rebaudiana. Phytochemistry 1976, 15, 981-983.
12. Sakamoto, I.; Yamasaki, K.; Tanaka, O. Application of 13C NMR spectroscopy to the chemistry of natural glycosides: rebaudioside C, a new sweet diterpene glycoside of Stevia rebaudiana. Chem. Pharm. Bull. 1977, 25, 844-6. (Pubitemid 8095244)
13. Chang, S. S.; Cook, J. M. Stability studies of stevioside and rebaudioside A in carbonated beverages. J. Agric. Food Chem. 1983, 31, 409-412.
14. 1HNMR spectroscopy. J. Pharm. Biomed. Anal. 2010, 52, 51-58.
15. Mallakin, A.; McConkey, B. J.; Miao, G.; McKibben, B.; Snieckus, V.; Dixon, D. G.; Greenberg, B. M. Impacts of structural photomodification on the toxicity of environmental contaminants: anthracene photooxidation products. Ecotoxicol. Environ. Saf. 1999, 43, 204-212. (Pubitemid 29256995)
16. 1H-NMR. Phytochem. Anal. 2004, 15, 325-330. (Pubitemid 39335411)
17. 1H-NMR. Chem. Pharm. Bull. 2004, 52, 718-721. (Pubitemid 41685511)
18. Saito, T.; Nakaie, S.; Kinoshita, M.; Ihara, T.; Kinugasa, S.; Nomura, A.; Maeda, T. Practical guide for accurate quantitative solution state NMR analysis. Metrologia 2004, 41, 213-218.