New roles for lysosomal traffi cking in morphogen gradient sensing

Science Signaling

Volumn 4, Issue 171, 2011, Pages

  Rainero, Elena ^a   Norman, Jim C ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MORPHOGEN; RAB PROTEIN; SMAD2 PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3;

CELL DIFFERENTIATION; CELL MIGRATION; CHEMOTAXIS; INTRACELLULAR SIGNALING; LYSOSOME; MULTIVESICULAR BODY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; XENOPUS; ANIMAL; EMBRYO DEVELOPMENT; HUMAN; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; EMBRYONIC DEVELOPMENT; HUMANS; LYSOSOMES;

EID: 79955691296     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2002053     Document Type: Review

References (18)

1. M. Nowak, A. Machate, S. R. Yu, M. Gupta, M. Brand, Interpretation of the FGF8 morphogen gradient is regulated by endocytic traffi cking. Nat. Cell Biol. 13, 153-158 (2011).
2. J. Jullien, J. Gurdon, Morphogen gradient interpretation by a regulated traffi cking step during ligand-receptor transduction. Genes Dev. 19, 2682-2694 (2005) (Pubitemid 41627935)
3. X. Yang, D. Dormann, A. E. Münsterberg, C. J. Weijer, Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev. Cell 3, 425-437 (2002)
4. J. B. Gurdon, P. Y. Bourillot, Morphogen gradient interpretation. Nature 413, 797-803 (2001) (Pubitemid 33026841)
5. J. B. Green, H. V. New, J. C. Smith, Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71, 731-739 (1992)
6. S. Dyson, J. B. Gurdon, The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93, 557-568 (1998) (Pubitemid 28240717)
7. G. W. Gould, J. Lippincott-Schwartz, New roles for endosomes: From vesicular carriers to multipurpose platforms. Nat. Rev. Mol. Cell Biol. 10, 287-292 (2009)
8. C. Raiborg, H. Stenmark, The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458, 445-452 (2009)
9. D. Mukhopadhyay, H. Riezman, Proteasomeindependent functions of ubiquitin in endocytosis and signaling. Science 315, 201-205 (2007) (Pubitemid 46166358)
10. G. M. Di Guglielmo, C. Le Roy, A. F. Goodfellow, J. L. Wrana, Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat. Cell Biol. 5, 410-421 (2003) (Pubitemid 36592263)
11. E. Galperin, V. V. Verkhusha, A. Sorkin, Threechromophore FRET microscopy to analyze multiprotein interactions in living cells. Nat. Methods 1, 209-217 (2004)
12. S. Kermorgant, P. J. Parker, Receptor traffi cking controls weak signal delivery: A strategy used by c-Met for STAT3 nuclear accumulation. J. Cell Biol. 182, 855-863 (2008)
13. C. Francavilla, P. Cattaneo, V. Berezin, E. Bock, D. Ami, A. de Marco, G. Christofori, U. Cavallaro, The binding of NCAM to FGFR1 induces a specifi c cellular response mediated by receptor traffi cking. J. Cell Biol. 187, 1101-1116 (2009)
14. K. Dorey, E. Amaya, FGF signalling: Diverse roles during early vertebrate embryogenesis. Development 137, 3731-3742 (2010)
15. E. M. Haugsten, V. Sørensen, A. Brech, S. Olsnes, J. Wesche, Different intracellular traffi cking of FGF1 endocytosed by the four homologous FGF receptors. J. Cell Sci. 118, 3869-3881 (2005) (Pubitemid 41410271)
16. E. M. Haugsten, J. Malecki, S. M. Bjørklund, S. Olsnes, J. Wesche, Ubiquitination of fi broblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol. Biol. Cell 19, 3390-3403 (2008)
17. G. Jékely, H. H. Sung, C. M. Luque, P. Rørth, Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev. Cell 9, 197-207 (2005) (Pubitemid 41051739)
18. Funding. E.R. and J.C.N. are funded by Cancer Research, UK.