Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Suzuki, Keiji ^a   Mitsutake, Norisato ^a,c   Saenko, Vladimir ^a   Suzuki, Masatoshi ^a   Matsuse, Michiko ^a   Ohtsuru, Akira ^b   Kumagai, Atsushi ^b   Uga, Tatsuya ^b   Yano, Hiroshi ^b   Nagayama, Yuji ^a   Yamashita, Shunichi ^a,b  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 18; PEROXIDASE; THYROGLOBULIN; VIMENTIN; PRIMER DNA;

ADIPOCYTE; ARTICLE; CELL CLONE; CELL DEATH; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE TECHNIQUE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; NERVE CELL; PROTEIN EXPRESSION; STEM CELL; THYROID CELL; THYROID FOLLICLE CELL; TISSUE SECTION; CYTOLOGY; DNA MICROARRAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; THYROID GLAND;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINEAGE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; STEM CELLS; THYROID GLAND;

EID: 79955684963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019354     Document Type: Article

References (31)

1. Burstein DE, Nagi C, Wang BY, Unger P, (2004) Immunohistochemical detection of p53 homolog p63 in solid cell nests, papillary thyroid carcinoma, and hashimoto's thyroiditis: A stem cell hypothesis of papillary carcinoma oncogenesis. Hum Pathol 35: 465-473.
2. Cameselle-Teijeiro J, Preto A, Soares P, Sobrinho-Simoes M, (2005) A stem cell role for thyroid solid cell nests. Hum Pathol 36: 590-591.
3. Preto A, Cameselle-Teijeiro J, Moldes-Boullosa J, Soares P, Cameselle-Teijeiro JF, et al. (2004) Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests. Mod Pathol 17: 819-826.
4. Reis-Filho JS, Preto A, Soares P, Ricardo S, Cameselle-Teijeiro J, et al. (2003) p63 expression in solid cell nests of the thyroid: further evidence for a stem cell origin. Mod Pathol 16: 43-48.
5. Thomas T, Nowka K, Lan L, Derwahl M, (2006) Expression of endoderm stem cell markers: evidence for the presence of adult stem cells in human thyroid glands. Thyroid 16: 537-544.
6. Lan L, Cui D, Nowka K, Derwahl M, (2007) Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes. J Clin Endocrinol Metab 92: 3681-3688.
7. Fierabracci A, Puglisi MA, Giuliani L, Mattarocci S, Gallinella-Muzi M, (2008) Identification of an adult stem/progenitor cell-like population in the human thyroid. J Endocrinol 198: 471-487.
8. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872.
9. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
10. Santisteban M, Reiman JM, Asiedu MK, Behrens MD, Nassar A, et al. (2009) Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 69: 2887-2895.
11. Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, et al. (2008) Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 3: e2888.
12. Kawabe Y, Eguchi K, Shimomura C, Mine M, Otsubo T, et al. (1989) Interleukin-1 production and action in thyroid tissue. J Clin Endocrinol Metab 68: 1174-1183.
13. Nakazawa Y, Saenko V, Rogounovitch T, Suzuki K, Mitsutake N, et al. (2008) Reciprocal paracrine interactions between normal human epithelial and mesenchymal cells protect cellular DNA from radiation-induced damage. Int J Radiat Oncol Biol Phys 71: 567-577.
14. Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92: 9363-9367.
15. Muller PY, Janovjak H, Miserez AR, Dobbie Z, (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-1374, 1376, 1378-1379.
16. Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM, (2000) Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275: 9390-9395.
17. Schweppe RE, Klopper JP, Korch C, Pugazhenthi U, Benezra M, et al. (2008) Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab 93: 4331-4341.
18. Buley ID, Gatter KC, Heryet A, Mason DY, (1987) Expression of intermediate filament proteins in normal and diseased thyroid glands. J Clin Pathol 40: 136-142.
19. Dockhorn-Dworniczak B, Franke WW, Schroder S, Czernobilsky B, Gould VE, et al. (1987) Patterns of expression of cytoskeletal proteins in human thyroid gland and thyroid carcinomas. Differentiation 35: 53-71.
20. Ramaekers F, Haag D, Jap P, Vooijs PG, (1984) Immunochemical demonstration of keratin and vimentin in cytologic aspirates. Acta Cytol 28: 385-392.
21. Lehmann I, Brylla E, Sittig D, Spanel-Borowski K, Aust G, (2000) Microvascular endothelial cells differ in their basal and tumour necrosis factor-alpha-regulated expression of adhesion molecules and cytokines. J Vasc Res 37: 408-416.
22. Patton WF, Yoon MU, Alexander JS, Chung-Welch N, Hechtman HB, et al. (1990) Expression of simple epithelial cytokeratins in bovine pulmonary microvascular endothelial cells. J Cell Physiol 143: 140-149.
23. Richter M, Tscheudschilsuren G, Eschke D, Aust G, Spanel-Borowski K, et al. (2002) Voltage-dependent potassium channels in cytokeratin-positive and cytokeratin-negative microvascular endothelial cells of the corpus luteum. Cell Tissue Res 310: 103-108.
24. Tscheudschilsuren G, Aust G, Nieber K, Schilling N, Spanel-Borowski K, (2002) Microvascular endothelial cells differ in basal and hypoxia-regulated expression of angiogenic factors and their receptors. Microvasc Res 63: 243-251.
25. Mattey DL, Nixon N, Wynn-Jones C, Dawes PT, (1993) Demonstration of cytokeratin in endothelial cells of the synovial microvasculature in situ and in vitro. Br J Rheumatol 32: 676-682.
26. Motoyama H, Ogawa S, Kubo A, Miwa S, Nakayama J, et al. (2009) In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors. Biochem Biophys Res Commun 385: 123-128.
27. Ma W, Yan RT, Li X, Wang SZ, (2009) Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2. Stem Cells 27: 1376-1387.
28. Grinnell KL, Yang B, Eckert RL, Bickenbach JR, (2007) De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4. J Invest Dermatol 127: 372-380.
29. Wiese C, Rolletschek A, Kania G, Navarrete-Santos A, Anisimov SV, et al. (2006) Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells 24: 2085-2097.
30. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, et al. (2009) A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 5: 491-503.
31. Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, et al. (2009) Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A 106: 8912-8917.