Immunohistochemical Detection of p53 Homolog p63 in Solid Cell Nests, Papillary Thyroid Carcinoma, and Hashimoto's Thyroiditis: A Stem Cell Hypothesis of Papillary Carcinoma Oncogenesis

Human Pathology

Volumn 35, Issue 4, 2004, Pages 465-473

  Burstein, David E ^a   Nagi, Chandandeep ^a   Wang, Beverly Y ^a   Unger, Pamela ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinogenesis; Hashimoto's thyroiditis; Immunohistochemistry; p63; Papillary carcinoma; Solid cell nests; Stem cell; Thyroglossal duct cyst; Thyroid; Ultimobranchial body

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; PROTEIN P53; PROTEIN P63;

ARTICLE; BRONCHUS MUCOSA; CARCINOGENESIS; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL MATURATION; EPITHELIUM CELL; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; PROTEIN EXPRESSION; SQUAMOUS EPITHELIUM; STEM CELL; THYROID PAPILLARY CARCINOMA; ULTIMOBRANCHIAL BODY;

EID: 1942453271     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2003.10.027     Document Type: Article

References (60)

1. Salabe GB: Pathogenesis of thyroid nodules: Histological classification? Biomed Pharmacother 55:39-53, 2001
2. Santoro M, Melillo RM, Grieco M, et al: The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line. Cell Growth Differ 4:77-84, 1993
3. Portella G, Vitagliano D, Borselli C, et al: Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells. Oncol Res 11:421-427, 1999
4. Bond JA, Wyllie FS, Rowson J, et al: In vitro reconstruction of tumour initiation in a human epithelium. Oncogene 9:281-290, 1994
5. Santoro M, Chiappetta G, Cerrato A, et al: Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene 12:1821-1826, 1996
6. Jhiang SM, Sagartz JE, Tong Q, et al: Targeted expression of the ret/ PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137:375-378, 1996
7. Powell DJ Jr, Russell J, Nibu K, et al: The RET/PTC3 oncogene: Metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res 58:5523-5528, 1998
8. Yang A, McKeon F: p63 and p73: p53 mimics, menaces and more. Nat Rev Mol Cell Biol 1:199-207, 2000
9. Yang A, Schweitzer R, Sun D, et al: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398:714-718, 1999
10. Mills AA, Zheng B, Wang XJ, et al: p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398:708-713, 1999
11. Pellegrini G, Dellambra E, Golisano O, et al: p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A 98:3156-3161, 2001
12. Unger P, Ewart M, Wang BY, et al: Expression of p63 in papillary thyroid carcinoma and in Hashimoto's thyroiditis: A pathologic link? HUM PATHOL 34:764-769, 2003
13. Harach HR: Solid cell nests of the thyroid. An anatomical survey and immunohistochemical study for the presence of thyroglobulin. Acta Anat 122:211-215, 1985
14. Harach HR: Solid cell nests of thyroid in early stages of postnatal life. Systematic autopsy study. Acta Anat 127:262-264, 1986
15. Beckner ME, Shultz JJ, Richardson T: Solid and cystic ultimobranchial body remnants in the thyroid. Arch Pathol Lab Med 114:1049-1052, 1990
16. Sugiyama S: The embryology of the human thyroid gland including ultimobranchial body and others related. Ergeb Anat Entwickl Gesch 44:3-111, 1971
17. Getzowa S: Uber die Glandula parathyroidea, intrathyreoidale Zellhaufen derselben und Rests des postbranchialen Korpers. Virchows Arch 188:181-234, 1907
18. Rogers WM: Normal and anomalous development of the thyroid, in Werner SC, Ingbar SH (eds): The Thyroid. New York, NY, Harper and Row, 1971, pp 303-317
19. Harach HR: Solid cell nests of the thyroid. J Pathol 155:191-200, 1988
20. Cameselle-Teijero J, Varela-Duran J, Sambade C, et al: Solid cell nests of the thyroid: Light microscopy and immunohistochemical profile. HUM PATHOL 25:684-693, 1994
21. Harach HR: Mixed follicles of the human thyroid. Acta Anat 129:27-30, 1987
22. Yamaoka Y: Solid cell nest (SCN) of the human thyroid gland. Acta Pathol (Jpn) 23:493-506, 1973
23. Fraser BA, Duckworth JWA: Ultimobranchial body cysts in the human foetal thyroid: Pathological implications. J Pathol 127:89-92, 1979
24. Fraser BA, Duckworth JWA: Position of ultimobranchial body cysts in the human fetal thyroid gland. Acta Anat 105:269-272, 1979
25. Mizukami Y, Nonomura A, Michigishi T, et al: Solid cell nests of the thyroid: A histologic and immunohistochemical study. Am J Clin Pathol 101:186-191, 1994
26. Auteliano F, Santeusanio G, diTondo U, et al: Immunohistochemical study of solid cell nests of the thyroid gland found from an autopsy study. Cancer 59:477-483, 1987
27. Janzer RC, Weber E, Hedinger C: The relation between solid cell nests and C cells of the thyroid gland: An immunohistochemical and morphometric investigation. Cell Tissue Res 197:295-312, 1979
28. Nadig J, Weber E, Hedinger C: C-cells in vestiges of the ultimobranchial body in human thyroid glands. Virchows Arch B Cell Pathol 27:189-191, 1978
29. Williams ED, Toyn CE, Harach HR: The ultimobranchial gland and congenital thyroid abnormalities in man. J Pathol 159:135-141, 1989
30. Wang BY, Gil J, Kaufman D, et al: p63 in pulmonary epithelium, pulmonary squamous neoplasms and other pulmonary tumors. HUM PATHOL 33:921-926, 2002
31. Wenig BM, Adair CF, Heffess CS: Primary mucoepidermoid carcinoma of the thyroid gland: A report of six cases and a review of the literature of a follicular epithelial-derived tumor. HUM PATHOL 26:1099-1108, 1995
32. Carpenter JL, Emery GR: Inclusions in the human thyroid. J Anat 122:77-89, 1976
33. Vollenweider I, Hedinger C: Solid cell nests (SCN) in Hashimoto's thyroiditis. Virchows Arch A Pathol Anat Histopathol 412:357-363, 1988
34. Rosai J, Carcangiu ML, DeLellis RA: Tumors of the Thyroid Gland. Washington, DC, Armed Forces Institute of Pathology, 1992
35. DiPasquale M, Rothstein JL, Palazzo JP: Pathologic features of Hashimoto's associated papillary thyroid carcinomas. HUM PATHOL 32:24-30, 2001
36. Wirtschafter A, Schmidt R, Rosen D, et al: Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis. Laryngoscope 107:1443-1450, 1998
37. Colby TV, Koss MN, Travis WD: Tumors of the Lower Respiratory Tract. Washington, DC, Armed Forces Institute of Pathology, 1995
38. O'Connell JT, Mutter GL, Cviko A, et al: Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: A study with the p53 homologue p63. Gynecol Oncol 80:30-36s, 2001
39. Park BJ, Lee SJ, Kim JI, et al: Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res 60:3370-3374, 2000
40. Black CC, Unger PD, Burstein DE, et al: Expression of p63 protein in subtypes of transitional cell and renal cell carcinoma. Mod Pathol 14:102A, 2001
41. Glickman JN, Yang A, Shahsafaei A, et al: Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. HUM PATHOL 32:1157-1165, 2001
42. Rosai J, Carcangiu ML, DeLellis RA: Tumors of the Thyroid Gland. Washington, DC, Armed Forces Institute of Pathology, 1992
43. Reis Filho JS, Preto A, Soares P, et al: p63 expression in solid cell nests of the thyroid: Further evidence for a stem cell origin. Mod Pathol 16:43-48, 2003
44. Katoh R, Sasaki J, Kurihara H, et al: Multiple thyroid involvement (intraglandular metastasis) in papillary thyroid carcinoma. A clinicopathologic study of 105 consecutive patients. Cancer 70:1585-1590, 1992
45. Harach HR: Solid cell nests of the thyroid. An anatomical survey and immunohistochemical study for the presence of thyroglobulin. Acta Anat 122:249-253, 1985
46. Harach HR: Solid cell nests of thyroid in early stages of postnatal life. Systematic autopsy study. Acta Anat 127:262-264, 1986
47. LiVolsi VA, Merino MJ: Squamous cells in the human thyroid gland. Am J Surg Pathol 2:133-140, 1978
48. DiPasquale M, Rothstein JL, Palazzo JP: Pathologic features of Hashimoto's associated papillary thyroid carcinomas. HUM PATHOL 32:24-30, 2001
49. Segal K, Ben-Bassat M, Avraham A, et al: Hashimoto's thyroiditis and carcinoma of the thyroid gland. Int Surg 70:205-209, 1985
50. Hirabayashi RN, Lindsay S: The relation of thyroid carcinoma and chronic thyroiditis. Surg Gynecol Obstet 121:243-252, 1965
51. Eisenberg BL, Hensley SD: Thyroid cancer with coexistent Hashimoto's thyroiditis. Clinical assessment and management. Arch Surg 124:1045-1047, 1989
52. Ott RA, McCall AR, McHenry C, et al: The incidence of thyroid carcinoma in Hashimoto's thyroiditis. Am Surg 53:442-445, 1987
53. Ott RA, Calandra DB, McCall A, et al: The incidence of thyroid carcinoma in patients with Hashimoto's thyroiditis and solitary cold nodules. Surgery 98:1202-1206, 1985
54. Sclafani AP, Valdes M, Cho H: Hashimoto's thyroiditis and carcinoma of the thyroid: Optimal management. Laryngoscope 103:845-849, 1993
55. Okayasu I, Fujiwara M, Hara Y, et al: Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. Cancer 76:2312-2318, 1995
56. Chesky VE, Hellwig CA, Welch JW: Cancer of the thyroid associated with Hashimoto's disease: Analysis of 48 cases. Am Surg 28:678-685, 1962
57. LiVolsi VA: Surgical Pathology of the Thyroid. Philadelphia, PA, Saunders, 1990
58. Rosai J, Carcangiu ML, DeLellis RA: Tumors of the Thyroid Gland. Washington, DC, Armed Forces Institute of Pathology, 1992
59. Franssila KO, Harach HR, Wasenius VM: Mucoepidermoid carcinoma of the thyroid. Histopathology 8:847-860, 1984
60. Rosai J, Carcangiu ML, DeLellis RA: Tumors of the Thyroid Gland. Washington, DC, Armed Forces Institute of Pathology, 1992