Continuous blood purification ameliorates RhoA-mediated endothelial permeability in severe acute pancreatitis patients with lung injury

International Journal of Artificial Organs

Volumn 34, Issue 4, 2011, Pages 348-356

  Du, Xiao Gang ^a   Chen, Xue Mei ^a   Gan, Hua ^a   Li, Zheng Rong ^a   Wen, Yu Jun ^a   Wang, Xi Chao ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Continuous blood purification (CBP); Endothelial permeability; Lung injury; RhoA; Severe acute pancreatiits (SAP)

Indexed keywords

BIOLOGICAL ORGANS; ENDOTHELIAL CELLS; PATIENT TREATMENT; PROTEINS; PURIFICATION;

BLOOD PURIFICATION; CONTINUOUS BLOOD PURIFICATION; ENDOTHELIAL PERMEABILITY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; LUNG INJURY; RHOA; SEVERE ACUTE PANCREATIITS; SEVERE ACUTE PANCREATITIS; STRESS FIBERS; Y-27632;

BLOOD;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; F ACTIN; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACUTE PANCREATITIS; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CLINICAL ARTICLE; CONTINUOUS BLOOD PURIFICATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM INJURY; ENZYME ACTIVITY; FEMALE; HEMATOLOGICAL PROCEDURES; HUMAN; HUMAN CELL; LUNG INJURY; MALE; MULTIPLE ORGAN FAILURE; SERUM; STRESS FIBER; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 79955668095     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/IJAO.2011.7742     Document Type: Article

References (29)

1. mrie CW, Ferguson JC, Murphy D, Blumgart LH. Arterial hypoxia in acute pancreatitis. Br J Surg 1977; 64 (3): 185-188. Medline. doi:10.1002/bjs.1800640310
2. Steinberg W, Tenner S. Acute pancreatitis. N Engl J Med 1994; 330 (17): 1198-210. Medline. doi:10.1056/ NEJM199404283301706
3. Browne GW, Pitchumoni CS. Pathophysiology of pulmonary complications of acute pancreatitis. World J Gastroenterol 2006; 12 (44): 7087-96. Medline.
4. Tetta C, Bellomo R, Ronco C. Artificial organ treatment for multiple organ failure, acute renal failure, and sepsis: recent new trends. Artif Organs 2003; 27 (3): 202-213. Medline. doi:10.1046/j.1525-1594.2003.00963.x
5. Schetz M. Non-renal indications for continuous renal replacement therapy. Kidney Int 1999; 56 (Suppl 72): S88-S94. doi:10.1046/j.1523-1755.56.s72.12.x
6. Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamura M. Continuous hemofiltration/hemodiafiltration in critical care. Ther Apher 2002; 6 (3): 193-198. Medline doi:10.1046/ j.1526-0968.2002.00431.x
7. Ronco C, Ricci Z, Bellomo R. Importance of increased ultrafiltration volume and impact on mortality: sepsis and cytokine story and the role for CVVH. EDTNA ERCA J 2002; (Suppl 2): 13-18 Medline.
8. Pupelis G, Austrums E, Snippe K. Blood purification methods for treatment of organ failure in patients with severe pancreatitis. Zentralbl Chir 2001; 126 (10): 780-784. Medline. doi:10.1055/s-2001-18264
9. Lam CF, Liu YC, Hsu JK, et al. Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits. Anesthesiology 2008; 108 (3): 392-401. Medline. doi:10.1097/ALN.0b013e318164ca64
10. Bradley EL III. A clinically based calssification system for acute pancreatitis. Summary of the international symposium on acute pancreatitis. Atlanta, Ga, September 11 through 13, 1992. Arch Surg 1993; 128 (5): 586-590. Medline.
11. Bernard GR, Artigas A, Brigham KL, et al. Report of the American European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med 1994; 20 (3): 225-232. Medline. doi:10.1007/BF01704707
12. Behzadian MA, Windsor LJ, Ghaly N, Liou G, Tsai NT, Caldwell RB. VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor. FASEB J 2003; 17 (6): 752-754. Medline.
13. Lecuona E, Ridge K, Pesce L, Batlle D, Sznajder JI. The GTPbinding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells. Mol Biol Cell 2003; 14 (9): 3888-3897. Medline. doi:10.1091/mbc.E02-12-0781
14. Beckers CM, van Hinsbergh VW, van Nieuw Amerongen GP. Driving Rho GTPase activity in endothelial cells regulates barrier integrity. Thromb Haemost 2010; 103 (1): 40-55. Medline.
15. Chen ZH, Liu ZH, Yu C, Ji DX, Li LS. Endothelial dysfunction in patients with severe acute pancreatitis: improved by continuous blood purification therapy. Int J Artif Organs 2007; 30 (5): 393-400. Medline.
16. Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 2001; 91 (4): 1487-1500. Medline.
17. Stevens T, Garcia JG, Shasby DM, Bhattacharya J, Malik AB. Mechanisms regulating endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 2000; 279 (3): L419-L422. Medline.
18. Dawes AT, Edelstein-Keshet L. Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophys J 2007; 92 (3): 744-768. Medline. doi:10.1529/biophysj.106.090514
19. Rosso L, Pierson PM, Golfier C, et al. Pituicyte stellation is prevented by RhoA-or Cdc42-dependent actin polymerization. Cell Mol Neurobiol 2007; 27 (6): 791-804. Medline. doi:10.1007/s10571-007-9176-7
20. van Nieuw Amerongen GP, van Delft S, Vermeer MA, Collard JG, van Hinsbergh VW. Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases. Circ Res 2000; 87 (4): 335-40. Medline.
21. Ridley AJ, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992; 70 (3): 389-99. Medline. doi:10.1016/0092-8674(92)90163-7
22. Wojciak-Stothard B, Entwistle A, Garg R, Ridley AJ. Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol 1998; 176 (1): 150-65. Medline. doi:10.1002/(SICI)1097-4652(199807)176:1<150::AIDJCP17> 3.0.CO;2-B
23. van Nieuw Amerongen GP, Beckers CM, Achekar ID, Zeeman S, Musters RJ, van Hinsbergh VW. Involvement of Rho kinase in endothelial barrier maintenance. Arterioscler Thromb Vasc Biol 2007; 27 (11): 2332-39. Medline. doi:10.1161/ATVBAHA. 107.152322
24. Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996; 273 (5272): 245-8. Medline. doi:10.1126/science. 273.5272.245
25. Campos SB, Ashworth SL, Wean S, et al. Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation. Am J Physiol Renal Physiol 2009; 296 (3): F487-F495. Medline. doi:10.1152/ajprenal.00112.2008
26. Johnson CD, Kingsnorth AN, Imrie CW, et al. Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001; 48 (1): 62-9. Medline. doi:10.1136/gut.48.1.62
27. Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998; 175 (1): 76-83. Medline. doi:10.1016/S0002-9610(97)00240-7
28. Werner J. Z'graggen K, Fernandez-del Castillo C, Lewandrowski KB, Compton CC, Warshaw AL. Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg 1999; 229 (6): 834-840. Medline. doi:10.1097/00000658-199906000-00010
29. Pupelis G, Plaudis H, Grigane A, Zeiza K, Purmalis G. Continuous veno-venous haemofiltration in the treatment of severe acute pancreatitis: 6-year experience. HPB (Oxford) 2007; 9 (4): 295-301. Medline.